Symptomatic bone marrow metastases in breast cancer: A retrospective cohort study

Article Oncology

Spine-specific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptor-positive breast cancer by activating glutamine-dependent mTOR signaling

Qingbing Meng et al.

Summary: This study reveals that LAPTM5 acts as a tumor suppressor in ER+ breast cancer and identifies the role of the CX3CL/CX3CR1/LAPTM5/glutamine axis in the spinal metastasis of this disease.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Review Oncology

The Therapeutic Challenge of Disseminated Bone Marrow Metastasis From HR-Positive HER2-Negative Breast Cancer: Case Report and Review of the Literature

Giovanna Garufi et al.

Summary: The efficacy and safety of combining endocrine therapy (ET) with CDK4/6 inhibitors for HR-positive HER2-negative metastatic breast cancer patients facing visceral crisis or life-threatening conditions pose challenges in daily clinical practice. While chemotherapy is typically the standard of care in clinical trials, the combination of ET and CDK4/6 inhibitors has demonstrated rapid and clinically impactful activity in clinical trials.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Successful Stabilization of Symptomatic Bone Marrow Metastasis Two Times in a Breast Cancer Patient

Hideko Akagi et al.

Summary: Bone marrow metastasis in breast cancer is rare but life-threatening. However, chemotherapy can significantly improve survival rates, as demonstrated in this case of a 62-year-old woman who recovered with eribulin therapy.

ANTICANCER RESEARCH (2021)

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Editorial Material Oncology