Journal
FRONTIERS IN ONCOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2023.1099731
Keywords
microwave ablation; ferroptosis; heat shock protein; hypoxia-inducible factor; nuclear factor erythroid 2-related factor 2; p53
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Microwave ablation is a thermal ablation method used for treating various tumors, which can locally control tumors that cannot be surgically removed. Ferroptosis is an iron-dependent cell death caused by cumulative reactive oxygen species and lipid peroxidation products. Recent evidence suggests that ferroptosis may play a crucial role in the tumor suppression induced by microwave ablation.
Microwave ablation has been one form of thermal ablation in treatments for many tumors, which can locally control unresectable tumors. Ferroptosis is iron-dependent cell death caused by the cumulative reactive oxygen species and lipid peroxidation products. Recently, increasing evidence has shown that ferroptosis might play a vital role in MWA-induced tumor suppression. In this article, we briefly illustrate the concept of ferroptosis, the related signal pathways and inducers, the basic principle of microwave ablation in killing tumors, and the key molecules released after microwave ablation. Then, we describe the cross-talking molecules between microwave ablation and ferroptosis, and discussed the potential mechanism of microwave ablation-induced ferroptosis. This review explores the therapeutic target of ferroptosis in enhancing the systemic antitumor effect after microwave ablation, providing theoretical support in combinational microwave ablation with pro-ferroptosis therapy.
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