4.6 Review

Emerging targeted and cellular therapies in the treatment of advanced and metastatic synovial sarcoma

Related references

Note: Only part of the references are listed.
Article Oncology

Cancer immunotherapy using artificial adjuvant vector cells to deliver NY-ESO-1 antigen to dendritic cells in situ

Shin-ichiro Fujii et al.

Summary: The artificial adjuvant vector cell (aAVC-NY-ESO-1) successfully induced NY-ESO-1-specific CTL response in tumors and promoted the maturation of dendritic cells (DCs), resulting in a strong antitumor effect.

CANCER SCIENCE (2022)

Article Medicine, General & Internal

Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma

F. L. Locke et al.

Summary: This international phase 3 trial showed that axicabtagene ciloleucel therapy significantly improved event-free survival and response in patients with early relapsed or refractory large B-cell lymphoma compared to standard care, despite the expected high-grade toxic effects.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Review Oncology

Immunotherapy of sarcomas with modified T cells

Preethika Mahalingam et al.

Summary: Modified T-cell therapies are being developed for sarcomas, with ongoing clinical trials evaluating tumor-specific chimeric antigen receptor T cells and high affinity T-cell receptor-transduced T cells. Challenges include HLA-restriction, non-immunogenic tumor microenvironments, and potential toxicities. Improving the specificity, signaling, proliferation, and persistence of modified TCRs and manipulating the sarcoma TME are necessary for optimal clinical responses.

CURRENT OPINION IN ONCOLOGY (2022)

Article Oncology

Soft Tissue Sarcoma, Version 2.2022

Margaret von Mehren et al.

Summary: Soft tissue sarcomas (STS) are rare malignancies with diverse clinical and pathological characteristics. The diagnosis and treatment of STS require a multidisciplinary team. The NCCN Clinical Practice Guidelines provide comprehensive recommendations for the management of STS, including diagnosis, evaluation, and treatment.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2022)

Meeting Abstract Oncology

IMPROVED ANTI-TUMOR ACTIVITY OF NEXT-GENERATION TCR-ENGINEERED T CELLS THROUGH CD8 CO-EXPRESSION

Gagan Bajwa et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Orthopedics

Epidemiology, incidence, and survival of synovial sarcoma subtypes: SEER database analysis

Mahmut Nedim Aytekin et al.

JOURNAL OF ORTHOPAEDIC SURGERY (2020)

Article Oncology

Synovial sarcoma: Do children do better?

Maria Anna Smolle et al.

Article Oncology

Overexpressed PRAME is a potential immunotherapy target in sarcoma subtypes

Jason Roszik et al.

CLINICAL SARCOMA RESEARCH (2017)

Article Chemistry, Multidisciplinary

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands

David Remillard et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Medicinal

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Natalie H. Theodoulou et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Chemistry, Medicinal

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Laetitia J. Martin et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Oncology

Age as an independent prognostic factor for survival of localised synovial sarcoma patients

Myrella Vlenterie et al.

BRITISH JOURNAL OF CANCER (2015)

Article Cell Biology

The MAGE protein family and cancer

Jenny L. Weon et al.

CURRENT OPINION IN CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

Duncan A. Hay et al.

MEDCHEMCOMM (2015)

Article Medicine, General & Internal

Adoptive T Cell Immunotherapy for Cancer

Karlo Perica et al.

RAMBAM MAIMONIDES MEDICAL JOURNAL (2015)

Article Immunology

Blockade of TGF-β Signaling Greatly Enhances the Efficacy of TCR Gene Therapy of Cancer

Gavin M. Bendle et al.

JOURNAL OF IMMUNOLOGY (2013)

Article Oncology

Incidence of soft tissue sarcoma and beyond

Giuseppe Mastrangelo et al.

CANCER (2012)

Review Biochemistry & Molecular Biology

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

Frances Wadelin et al.

MOLECULAR CANCER (2010)

Article Oncology

Synovial Sarcoma

Emanuela Palmerini et al.

CANCER (2009)

Article Oncology

Primary adult soft tissue sarcoma: Time-dependent influence of prognostic variables

A Stojadinovic et al.

JOURNAL OF CLINICAL ONCOLOGY (2002)

Article Multidisciplinary Sciences

Monitoring CD8 T cell responses to NY-ESO-1:: Correlation of humoral and cellular immune responses

E Jäger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)