NIR Laser Integration of Photodetector on 3D Printed Chamber for Colorimetric Biosensing

In this work, gold nanoparticles (Au NPs)/indium-zinc-oxide (IZO) nanocomposite visible photodetector (PD) is directly prepared by near-infrared (NIR) laser-annealing on a 3D-printed substrate to form an integrated colorimetric sensor. After a surface planarization process, using a low power laser treatment without damaging the substrate, Au NPs are formed from the Au thin layer (6 nm) on 3D-printed resin substrate by laser-assisted dewetting process. Also, the UV-vis photoresponsivity is compared by tuning different NIR laser power intensity for sol-gel IZO curing. By investigating the temperature profile of each laser annealing process and the surface morphology of Au NPs/IZO nanocomposite film, the optimized PD is then integrated with a 3D-printed sensing chamber for successfully demonstrating urea detection varied from 1, 5, 10, 25 and 50 x 10(-3) m, which refer to the salivary urea concentrations for healthy and chronic kidney disease groups.

Automated summary

In this work, a gold nanoparticles/indium-zinc-oxide nanocomposite visible photodetector is directly prepared by laser-annealing on a 3D-printed substrate. The photodetector is integrated with a 3D-printed sensing chamber to successfully detect the urea concentration in saliva samples from healthy and chronic kidney disease groups.