Isocyanide chemistry enabled by continuous flow technology

Isocyanides are valuable compounds for organic synthesis. However, the poor stability and distressing odour have often limited their widespread applications in common laboratory practice and industrial settings. Herein, a continuous flow approach to enable the synthesis, purification and in-line reaction of isocyanides is presented.

Automated summary

This paper presents a continuous flow approach to address the issues of poor stability and distressing odor of isocyanides, allowing for their synthesis, purification, and in-line reaction.