Journal
CELLS
Volume 11, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/cells11243964
Keywords
glutathione; STEMI; primary PCI; angioplasty; reperfusion injury
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This review focuses on the role of Glutathione (GSH) in protecting myocardial cells from reperfusion damage. The authors provide an extensive discussion on the intrinsic antioxidant properties of GSH, its current applications in clinical practice, and future perspectives.
Ischemia-Reperfusion Injury (IRI) is responsible for adverse outcomes in patients with ST-Elevation Myocardial Infarction (STEMI). Oxidative stress, resulting from the production of Reactive Oxygen Species (ROS) and low availability of Glutathione (GSH), are the two main mediators of IRI. The effectiveness of exogenous antioxidant therapy in this scenario is still debated, since the encouraging results obtained in animal models have not been fully reproduced in clinical studies. In this review we focus on the role of GSH, specifically on the biomolecular mechanisms that preserve myocardial cells from damage due to reperfusion. In this regard, we provide an extensive discussion about GSH intrinsic antioxidant properties, its current applications in clinical practice, and the future perspectives.
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