4.6 Review

HIF-1α Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases

Related references

Note: Only part of the references are listed.
Article Cell Biology

Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1α/VEGFA axis by delivering microRNA-26a-5p

Dan Zhang et al.

Summary: The specific effects and underlying mechanism of urine-derived stem cells-extracellular vesicles (USCs-EVs) on osteoporosis in diabetes rats were studied. It was found that USCs-EVs carrying miR-26a-5p activated the HIF-1α/VEGFA pathway through HDAC4 inhibition to prevent diabetic osteoporosis (DOP).

CELL BIOLOGY AND TOXICOLOGY (2023)

Article Biochemistry & Molecular Biology

Osteostatin improves the Osteogenic differentiation of mesenchymal stem cells and enhances angiogenesis through HIF-1α under hypoxia conditions in vitro

Dongjin Wu et al.

Summary: This study found that osteostatin (OST) improved the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs) under hypoxia conditions, and further promoted angiogenesis of type H endothelial cells (ECs). These effects may be achieved through upregulating HIF-1 alpha expression.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Article Endocrinology & Metabolism

MIF does only marginally enhance the pro-regenerative capacities of DFO in a mouse-osteotomy-model of compromised bone healing conditions

Annemarie Lang et al.

Summary: The initial phase of fracture healing is crucial for bone regeneration, with dysregulation potentially leading to delayed healing. Stabilizing HIF-1 alpha may be a cost-effective preventive strategy for bone healing disorders, enhancing calcification and osteogenic differentiation of MSCs in vitro. Further research is needed to explore the potential synergistic effects of different HIF stabilizers and enhancers in improving fracture healing outcomes.
Article Dentistry, Oral Surgery & Medicine

HIF-1α regulates osteoclast activation and mediates osteogenesis during mandibular bone repair via CT-1

Yuanye Tian et al.

Summary: HIF-1 alpha plays a key role in osteoclastogenesis and bone resorption during fracture healing, and influences bone healing through CT-1 secretion. These findings are important for understanding the pathogenesis of bone diseases.

ORAL DISEASES (2022)

Article Nanoscience & Nanotechnology

Effect of Hypoxia-Inducible Factor-1' on Osteogenesis of Titanium Dioxide Nanotube Bone Marrow Mesenchymal Stem Cells with Different Diameters Under Periodic Tensile Stress

Yu Meng et al.

Summary: This study assessed the effect of titanium dioxide nanotubes with different diameters on ossification of bone marrow mesenchymal stem cells (BMSC) and the expression of HIF-1a. The results showed that nanotubes of different diameters had different effects on cell proliferation, ossification level, and molecular expression in BMSC.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2022)

Article Biochemistry & Molecular Biology

Demethylase FTO promotes mechanical stress induced osteogenic differentiation of BMSCs with up-regulation of HIF-1α

Renhao Sun et al.

Summary: This study investigated the effects of demethyltransferase FTO on osteogenic differentiation of BMSCs under mechanical stress condition. The results showed that FTO promoted the expression of HIF-1α and osteogenic differentiation in BMSCs under mechanical stress.

MOLECULAR BIOLOGY REPORTS (2022)

Article Rheumatology

Role of Lysine-Specific Demethylase 1 in Metabolically Integrating Osteoclast Differentiation and Inflammatory Bone Resorption Through Hypoxia-Inducible Factor 1α and E2F1

Kohei Doi et al.

Summary: This study reveals the metabolic role of LSD1 in regulating inflammatory bone resorption in patients with rheumatoid arthritis, providing potential new therapeutic strategies for the management of inflammatory arthritis.

ARTHRITIS & RHEUMATOLOGY (2022)

Article Cell Biology

Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation

Kaizhe Chen et al.

Summary: The activation of HIF-1 alpha signaling has potential implications for treating bone diseases. This study found that the osteocyte-specific HIF-1 alpha pathway plays a critical role in bone mass accrual, material properties, and micro-structures, as well as regulating bone remodeling through impairing osteocyte differentiation and maturation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Pharmacology & Pharmacy

Fracture repair by IOX2: Regulation of the hypoxia inducible factor-1a signaling pathway and BMSCs

Chunxia Chen et al.

Summary: The HIF-1 alpha PHD inhibitor IOX2 improves the proliferation and migration of BMSCs by upregulating intracellular Ca2+ and decreasing ROS, thus promoting fracture healing.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

HIF-1α protects osteoblasts from ROS-induced apoptosis

Xiaohui Wang et al.

Summary: Both HIF-1α and HIF-2α have a protective role in oxidative stress-induced apoptosis by regulating apoptosis-related proteins and stabilizing ROS levels.

FREE RADICAL RESEARCH (2022)

Article Cell Biology

Zinc and hypoxic preconditioning: a strategy to enhance the functionality and therapeutic potential of bone marrow-derived mesenchymal stem cells

Syed Faizan Ali Rizvi et al.

Summary: This study investigated the effects of ZnCl2 on the proliferation, morphology, migration, and gene expression of BM-MSCs under hypoxic and normoxic environments. It was found that zinc significantly enhanced BM-MSC proliferation, promoted cell migration, and improved cell morphology during the aging process.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

Article Orthopedics

Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

Luyao Li et al.

Summary: This study investigated the effects of roxadustat on osteoblast differentiation and bone remodeling in an OVX rat model. The results showed that roxadustat promoted osteoblast differentiation, prevented bone loss, and improved bone microarchitecture in OVX rats. Therefore, roxadustat may be a promising strategy for the treatment of osteoporosis.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2022)

Article Endocrinology & Metabolism

The Proliferation and Stemness of Peripheral Blood-Derived Mesenchymal Stromal Cells Were Enhanced by Hypoxia

Pengzhen Wang et al.

Summary: This study aimed to address the dilemma of low activity and reduced phenotype of peripheral blood-derived mesenchymal stromal cells (PBMSCs) in bone or cartilage tissue engineering. The findings showed that 5% oxygen hypoxia promoted cell proliferation and stemness expression, and increased the expression of cell cycle and stemness-related genes. The appropriate concentration of hypoxia enhanced the proliferation and stemness of PBMSCs, and increased the multidirectional differentiation potential.

FRONTIERS IN ENDOCRINOLOGY (2022)

Review Pharmacology & Pharmacy

Effects of BMSC-Derived EVs on Bone Metabolism

Xuchang Zhou et al.

Summary: Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells. EVs, especially BMSC-EVs, have therapeutic effects such as tissue repair, inhibition of macrophage polarization, and promotion of angiogenesis. BMSC-EVs also serve as efficient nanocarriers for drug delivery with advantages such as low immunogenicity, no ethical controversy, good stability, and easy storage.

PHARMACEUTICS (2022)

Article Biotechnology & Applied Microbiology

Copper-Lithium-Doped Nanohydroxyapatite Modulates Mesenchymal Stem Cells Homing to Treat Glucocorticoids-Related Osteonecrosis of the Femoral Head

Qianhao Li et al.

Summary: Cu-Li-nHA scaffold promotes MSCs homing and induces their osteogenic differentiation, enhancing bone regeneration during ONFH repair.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Article Engineering, Biomedical

Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway

Yu Zhuang et al.

Summary: Angiogenesis is crucial for ideal bone regeneration, and promoting angiogenesis during bone repair is vital. Hypoxia-preconditioned small extracellular vesicles (hypo-sEVs) derived from mesenchymal stem cells (MSCs) enhance angiogenesis through the miR-210-3p/EFNA3/PI3K/AKT pathway, providing an effective strategy for vascularized bone regeneration.

ACTA BIOMATERIALIA (2022)

Article Engineering, Biomedical

N-cadherin mimetic hydrogel enhances MSC chondrogenesis through cell metabolism

Wencan Ke et al.

Summary: This study reveals for the first time the role of cell metabolism in hypertrophy during mesenchymal stem cells (MSCs) chondrogenesis and demonstrates that a N-cadherin mimetic hydrogel can inhibit hypertrophy and enhance chondrogenesis through metabolic regulation.

ACTA BIOMATERIALIA (2022)

Article Biochemistry & Molecular Biology

Hypoxic condition induced H3K27me3 modification of the LncRNA Tmem235 promoter thus supporting apoptosis of BMSCs

Fei Zhang et al.

Summary: Bone marrow mesenchymal stem cells (BMSCs) have great potential for treating clinical diseases, but they undergo apoptosis in hypoxic conditions, affecting the treatment efficacy. This study identified the role of the HIF-1α/EZH2 signaling axis in promoting H3K27me3 modification of the LncRNA Tmem235 promoter, resulting in reduced expression of LncRNA Tmem235 and hypoxic apoptosis of BMSCs.

APOPTOSIS (2022)

Article Genetics & Heredity

LncRNA-mRNA Expression Profiles of Osteoclast After Conditional Knockout HIF-1α

Yuanye Tian et al.

Summary: In this study, RNA sequencing was used to analyze the expression profiles of lncRNAs and mRNAs in conditional HIF-1 alpha-knockout osteoclasts. Differential expression of 1,320 mRNAs and 95 lncRNAs was observed, with lncRNAs MSTRG.7566.12 and MSTRG.31769.2 showing strong negative correlation with the expression of genes such as Mmp9 and Ctsk. These findings provide insights into the regulation of osteoclast differentiation by HIF-1 alpha at the genetic level and suggest potential therapeutic targets for bone diseases related to HIF-1 alpha.

FRONTIERS IN GENETICS (2022)

Article Medicine, Research & Experimental

HIF/Ca2+/NO/ROS is critical in roxadustat treating bone fracture by stimulating the proliferation and migration of BMSCs

Chunxia Chen et al.

Summary: The study demonstrated that FG4592 promotes the proliferation and migration of BMSCs, accelerating fracture healing. Additionally, HIF-1 alpha plays a crucial role in this process.

LIFE SCIENCES (2021)

Article Cell Biology

The Effect of MMP-2 Inhibitor 1 on Osteogenesis and Angiogenesis During Bone Regeneration

Liangjun Jiang et al.

Summary: Recent studies have shown that MMP2-I1 plays a positive role in the osteogenesis of human bone marrow mesenchymal stem cells and angiogenesis of human vascular endothelial cells. It activates signaling pathways to promote osteogenesis and angiogenesis, and has been found to enhance bone formation and prevent bone loss in animal models.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Medicine, General & Internal

Hypoxia Enhanced Bone Regeneration Through the HIF-1α/β-Catenin Pathway in Femoral Head Osteonecrosis

HaiYan Zhao et al.

Summary: The study found that hypoxic preprocessing promoted the viability and functionality of BMSCs, increased the expression of growth factors during bone regeneration, reduced apoptosis, and enhanced bone formation. In vivo experiments also showed that hypoxia-pretreated BMSCs had better effects in repairing ONFH.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2021)

Review Biochemistry & Molecular Biology

Remodeling of Bone Marrow Niches and Roles of Exosomes in Leukemia

Takanori Yamaguchi et al.

Summary: Leukemia originates from hematopoietic stem cells in the bone marrow and treatment includes chemotherapy and hematopoietic stem cell transplantation. However, drug resistance and relapse remain challenges in leukemia management.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell & Tissue Engineering

Lithium and Copper Induce the Osteogenesis-Angiogenesis Coupling of Bone Marrow Mesenchymal Stem Cells via Crosstalk between Canonical Wnt and HIF-1α Signaling Pathways

Zhen Tan et al.

Summary: The study demonstrated that lithium and copper doped bioactive scaffolds can activate canonical Wnt and HIF-1 alpha signaling pathways, leading to the coupling of osteogenesis and angiogenesis in BMSCs. The sustained release of lithium and copper from the scaffold upregulated osteogenesis- and angiogenesis-related gene expression through crosstalk between the two pathways.

STEM CELLS INTERNATIONAL (2021)

Article Physiology

Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium

Yarong Wang et al.

Summary: The study found that a hypoxic environment and rough titanium implant surface promote osteogenic differentiation of osteoblasts and activate the JAK1/STAT1/HIF-1 alpha pathway in vitro. In animal studies, bone repair at high altitudes was slower than at low altitudes after 2 weeks, but bone formation did not differ significantly after 4 weeks. The results suggest that the altitude hypoxia environment affects the early osseointegration of titanium implants, with rough surfaces mitigating the effects.

FRONTIERS IN PHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

Cobalt doped nano-hydroxyapatite incorporated gum tragacanth-alginate beads as angiogenic-osteogenic cell encapsulation system for mesenchymal stem cell based bone tissue engineering

Senthilguru Kulanthaivel et al.

Summary: The study developed an efficient hMSC encapsulation system using bivalent cobalt doped nano-hydroxyapatite and gum tragacanth as angiogenic-osteogenic components. Experimental results showed that the encapsulation system supported hMSC growth, reduced reactive oxygen species production, promoted osteogenic differentiation marker expression, and enhanced vascular formation.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis

Michael Hepp et al.

Summary: The study found that oxidative stress in Hashimoto's thyroiditis results from an increase in reactive oxygen species and a decrease in antioxidant defenses. Moreover, oxidative stress leads to abnormal expression of several proteins, potentially exacerbating the pathophysiology of the disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Distinct Concentration-Dependent Molecular Pathways Regulate Bone Cell Responses to Cobalt and Chromium Exposure from Joint Replacement Prostheses

Karan M. Shah et al.

Summary: This study investigates the effects of systemic and periprosthetic metal exposure on bone cells through gene expression analysis. Systemic exposure primarily inhibits osteoclast activity while periprosthetic exposure inhibits both osteoblast and osteoclast activity and increases inflammatory signaling. Gene clusters and pathways correlating with metal toxicity are identified, along with potential early markers of metal toxicity. Additionally, the study provides insights into the molecular basis for improved clinical outcomes with hydroxyapatite-coated prostheses compared to other surfaces in the presence of metal exposure.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Engineering, Biomedical

Porous copper- and lithium-doped nano-hydroxyapatite composite scaffold promotes angiogenesis and bone regeneration in the repair of glucocorticoids-induced osteonecrosis of the femoral head

Bohua Li et al.

Summary: GIONFH is a common refractory disease, and in this study, a nano-hydroxyapatite-copper-lithium (Cu-Li-nHA) composite porous scaffold was synthesized to promote osteogenesis and angiogenesis for GIONFH repair by regulating the Wnt beta-catenin and HIF-1 alpha/VEGF pathways. The 0.25% Cu-Li-nHA scaffold showed the highest mechanical and biocompatibility, enhancing new bone formation in GIONFH rabbit models by upregulating osteogenic and angiogenic factors along with activating factors in the Wnt beta-catenin and HIF-1 alpha/VEGF pathways.

BIOMEDICAL MATERIALS (2021)

Article Biochemistry & Molecular Biology

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis

Shuo Ni et al.

Summary: This study demonstrates the involvement of ferroptosis in osteoclast differentiation induced by RANKL, with mechanisms including iron-starvation response and ferritinophagy. It also reveals the impact of HIF-1 alpha on ferritinophagy and autophagy flux under hypoxia conditions. Ferroptosis induction in osteoclasts through targeting HIF-1 alpha and ferritin may offer a novel therapeutic approach for osteoporosis.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Biochemistry & Molecular Biology

Deferoxamine Reduces Inflammation and Osteoclastogenesis in Avulsed Teeth

Ko Eun Lee et al.

Summary: The study demonstrates that deferoxamine (DFO) can effectively suppress inflammation and bone resorption, as well as regulate gene expression and ROS production, making it a potential new option for root surface treatment in avulsed teeth.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell & Tissue Engineering

Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis

Jie Bai et al.

Summary: LLLT enhances vascularized bone regeneration by coupling angiogenesis and osteogenesis. ROS/HIF-1 alpha is necessary for these effects of LLLT, and there may be a positive feedback loop between ROS and HIF-1 alpha, further amplifying HIF-1 alpha induction.

STEM CELL RESEARCH & THERAPY (2021)

Article Materials Science, Biomaterials

3D printing of Cu-doped bioactive glass composite scaffolds promotes bone regeneration through activating the HIF-1α and TNF-α pathway of hUVECs

Qiyuan Dai et al.

Summary: This study demonstrated that Cu-BG particles can enhance angiogenesis by activating hUVECs and promote osteogenic differentiation of BMSCs. A 3D-printed scaffold containing Cu-BG showed profound angiogenesis effects in rat bone defect repairs. A hydrogel containing 1 wt% 2Cu-BG effectively regulated the spatiotemporal coupling of vascularization and osteogenesis.

BIOMATERIALS SCIENCE (2021)

Article Nanoscience & Nanotechnology

Potential Osteoinductive Effects of Hydroxyapatite Nanoparticles on Mesenchymal Stem Cells by Endothelial Cell Interaction

Zhongyi Wang et al.

Summary: Nano-hydroxyapatite (nano-HA) has attracted attention in regenerative medicine, and its interaction with endothelial cells (ECs) and mesenchymal stem cells (MSCs) for bone reconstruction has been studied. The study found that HA nanoparticles (HANPs) could increase the viability and osteogenic gene expression of MSCs at subcytotoxic doses, with effects mediated by HIF-1 alpha secreted by ECs and triggering the ERK1/2 signaling cascade. A mathematical model showed a dose-dependent stimulatory effect of HIF-1 alpha on MSC osteogenic differentiation. These cooperative interactions may stimulate bone regeneration.

NANOSCALE RESEARCH LETTERS (2021)

Article Endocrinology & Metabolism

HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway

Wen-Ning Xu et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Medicine, Research & Experimental

Bone marrow- and adipose tissue-derived mesenchymal stem cells from donors with coronary artery disease; growth, yield, gene expression and the effect of oxygen concentration

Emma Adolfsson et al.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2020)

Article Cell & Tissue Engineering

Proangiogenic Hypoxia-Mimicking Agents Attenuate Osteogenic Potential of Adipose Stem/Stromal Cells

Ahmed G. Abu-Shahba et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2020)

Review Biotechnology & Applied Microbiology

Biochemical Signals Mediate the Crosstalk between Cartilage and Bone in Osteoarthritis

Xuchang Zhou et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Article Cell & Tissue Engineering

Hypoxia alleviates dexamethasone-induced inhibition of angiogenesis in cocultures of HUVECs and rBMSCs via HIF-1α

Miaomiao Chai et al.

STEM CELL RESEARCH & THERAPY (2020)

Article Biotechnology & Applied Microbiology

BMSC-Exosomes Carry Mutant HIF-1α for Improving Angiogenesis and Osteogenesis in Critical-Sized Calvarial Defects

Chenting Ying et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

Hypoxic Regulation of Gene Transcription and Chromatin: Cause and Effect

Jessica D. Kindrick et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Materials Science, Biomaterials

In vitro and in vivo evaluation of the pH-neutral bioactive glass as high performance bone grafts

Huiyu Zhao et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Cell & Tissue Engineering

Dimethyloxalyl Glycine Regulates the HIF-1 Signaling Pathway in Mesenchymal Stem Cells

Binjie Zhou et al.

STEM CELL REVIEWS AND REPORTS (2020)

Article Biochemistry & Molecular Biology

miR-31-5p Is a LIPUS-Mechanosensitive MicroRNA that Targets HIF-1α Signaling and Cytoskeletal Proteins

Viviana Costa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, Research & Experimental

Sinomenine mitigates collagen-induced arthritis mice by inhibiting angiogenesis

Zhi-tao Feng et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Critical Care Medicine

Photobiomodulation therapy (PBMT) in bone repair: A systematic review

Jose Stalin Bayas Escudero et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2019)

Article Biotechnology & Applied Microbiology

The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment

Qin Zhou et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Article Medicine, Research & Experimental

miR-149-3p Regulates the Switch between Adipogenic and Osteogenic Differentiation of BMSCs by Targeting FTO

Yuan Li et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Article Biochemistry & Molecular Biology

Cellular hypoxia promotes osteogenic differentiation of mesenchymal stem cells and bone defect healing via STAT3 signaling

Xin Yu et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2019)

Article Pharmacology & Pharmacy

Antiosteoporotic activities of isoquercitrin in ovariectomized rats: Role of inhibiting hypoxia inducible factor-1 alpha

Hadeer A. Fayed et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Engineering, Biomedical

3D-porous -tricalcium phosphate-alginate-gelatin scaffold with DMOG delivery promotes angiogenesis and bone formation in rat calvarial defects

Shahrbanoo Jahangir et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2019)

Article Biochemistry & Molecular Biology

Hypoxia-Mimicking Cobalt-Doped Borosilicate Bioactive Glass Scaffolds with Enhanced Angiogenic and Osteogenic Capacity for Bone Regeneration

Zhengwei Deng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Nutrition & Dietetics

NUPR1 acts as a pro-survival factor in human bone marrow-derived mesenchymal stem cells and is induced by the hypoxia mimetic reagent deferoxamine

Kazuhito Matsunaga et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2019)

Article Biochemistry & Molecular Biology

Repair of Critical-Sized Mandible Defects in Aged Rat Using Hypoxia Preconditioned BMSCs with Up-regulation of Hif-1α

Jiankang Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Article Medicine, Research & Experimental

Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism

Naomi Dirckx et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Dentistry, Oral Surgery & Medicine

Emerging Role of Extracellular Vesicles in Bone Remodeling

M. Liu et al.

JOURNAL OF DENTAL RESEARCH (2018)

Article Materials Science, Ceramics

Cobalt-containing bioactive glasses reduce human mesenchymal stem cell chondrogenic differentiation despite HIF-1α stabilisation

E. Littmann et al.

JOURNAL OF THE EUROPEAN CERAMIC SOCIETY (2018)

Article Materials Science, Biomaterials

Deferoxamine loaded titania nanotubes substrates regulate osteogenic and angiogenic differentiation of MSCs via activation of HIF-1 alpha signaling

Qichun Ran et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Article Endocrinology & Metabolism

Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects

Gabriela G. Loots et al.

Article Cell & Tissue Engineering

Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes

Felipe Monte et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

Article Chemistry, Medicinal

Icariin promotes the migration of bone marrow stromal cells via the SDF-1 alpha/HIF-1 alpha/CXCR4 pathway

Haiyan Zhu et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

Article Cell & Tissue Engineering

Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

Ben Antebi et al.

STEM CELL RESEARCH & THERAPY (2018)

Article Endocrinology & Metabolism

The Pathophysiological Sequence of Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Male Mice

Robert S. Weinstein et al.

ENDOCRINOLOGY (2017)

Article Biochemistry & Molecular Biology

Targeting the long noncoding RNA MALAT1 blocks the pro-angiogenic effects of osteosarcoma and suppresses tumour growth

Zhi-Chang Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

Osteocyte Alterations Induce Osteoclastogenesis in an In Vitro Model of Gaucher Disease

Constanza Bondar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Materials Science, Biomaterials

Deferoxamine immobilized poly(D,L-lactide) membrane via polydopamine adhesive coating: The influence on mouse embryo osteoblast precursor cells and human umbilical vein endothelial cells

Huihua Li et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Review Immunology

Cellular and molecular perspectives in rheumatoid arthritis

Douglas J. Veale et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

Article Cell & Tissue Engineering

Hypoxia Enhances Cell Properties of Human Mesenchymal Stem Cells

Se Yun Kwon et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

Article Cell Biology

Human type H vessels are a sensitive biomarker of bone mass

Liang Wang et al.

CELL DEATH & DISEASE (2017)

Article Cell & Tissue Engineering

Hypoxia Enhances Cell Properties of Human Mesenchymal Stem Cells

Se Yun Kwon et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

Article Integrative & Complementary Medicine

Phytochemistry and Pharmacology of Carthamus tinctorius L.

Le-Le Zhang et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2016)

Article Materials Science, Biomaterials

Cobalt doped proangiogenic hydroxyapatite for bone tissue engineering application

Senthilguru Kulanthaivel et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

Article Cell & Tissue Engineering

Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation

Laura C. Shum et al.

STEM CELLS AND DEVELOPMENT (2016)

Review Biotechnology & Applied Microbiology

Hypoxia-inducible factor-1 expression predicts osteosarcoma patients' survival: a meta-analysis

Yurong Ouyang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2016)

Article Cell Biology

HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression

Jin Shao et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2015)

Review Rheumatology

Role of HIF-1α and HIF-2α in osteoarthritis

Fang-Jie Zhang et al.

JOINT BONE SPINE (2015)

Article Cell & Tissue Engineering

HIF-1A and C/EBPs transcriptionally regulate adipogenic differentiation of bone marrow-derived MSCs in hypoxia

Chen Jiang et al.

STEM CELL RESEARCH & THERAPY (2015)

Article Materials Science, Biomaterials

3D-printed dimethyloxallyl glycine delivery scaffolds to improve angiogenesis and osteogenesis

Zhu Min et al.

BIOMATERIALS SCIENCE (2015)

Article Endocrinology & Metabolism

Therapeutic Effect of Deferoxamine on Iron Overload-Induced Inhibition of Osteogenesis in a Zebrafish Model

Bin Chen et al.

CALCIFIED TISSUE INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

Dimethyloxaloylglycine Improves Angiogenic Activity of Bone Marrow Stromal Cells in the Tissue- Engineered Bone

Hao Ding et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)

Article Engineering, Biomedical

Laser-induced osteoblast proliferation is mediated by ROS production

Mario Migliario et al.

LASERS IN MEDICAL SCIENCE (2014)

Article Multidisciplinary Sciences

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

Anjali P. Kusumbe et al.

NATURE (2014)

Article Multidisciplinary Sciences

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

Saravana K. Ramasamy et al.

NATURE (2014)

Article Multidisciplinary Sciences

Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation

Jenna N. Regan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability

Yun-Hee Choi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Src kinases mediate VEGFR2 transactivation by the osteostatin domain of PTHrP to modulate osteoblastic function

Adela Garcia-Martin et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2013)

Article Dentistry, Oral Surgery & Medicine

Advances in the Regulation of Osteoclasts and Osteoclast Functions

B. F. Boyce

JOURNAL OF DENTAL RESEARCH (2013)

Review Genetics & Heredity

Ocular neovascularization

Peter A. Campochiaro

JOURNAL OF MOLECULAR MEDICINE-JMM (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Endocrinology & Metabolism

Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing

Tomoaki Fukui et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2012)

Article Biochemistry & Molecular Biology

Hypoxia-inducible Factor-1α Protein Negatively Regulates Load-induced Bone Formation

Ryan C. Riddle et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Orthopedics

Increasing Vascularity to Improve Healing of a Segmental Defect of the Rat Femur

Rena Stewart et al.

JOURNAL OF ORTHOPAEDIC TRAUMA (2011)

Article Medicine, General & Internal

Hypoxia Induces Osteogenesis-Related Activities and Expression of Core Binding Factor α1 in Mesenchymal Stem Cells

Jiao Huang et al.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Review Critical Care Medicine

Hypoxia-inducible factors and the prevention of acute organ injury

Samuel N. Heyman et al.

CRITICAL CARE (2011)

Article Cardiac & Cardiovascular Systems

Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload

Gillian C. Smith et al.

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE (2011)

Article Cell Biology

Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1α

Damian C. Genetos et al.

CELL AND TISSUE RESEARCH (2010)

Article Cell Biology

Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells

Antonina Lavrentieva et al.

CELL COMMUNICATION AND SIGNALING (2010)

Review Biochemistry & Molecular Biology

Hypoxia-Inducible Factor-1 as Regulator of Angiogenesis in Rheumatoid Arthritis - Therapeutic Implications

J. Westra et al.

CURRENT MEDICINAL CHEMISTRY (2010)

Review Biotechnology & Applied Microbiology

The Regulation of Differentiation in Mesenchymal Stem Cells

Andrea Augello et al.

HUMAN GENE THERAPY (2010)

Article Medicine, Research & Experimental

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

Emma C. Walker et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Chemistry, Physical

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

M. M. Azevedo et al.

JOURNAL OF MATERIALS CHEMISTRY (2010)

Article Endocrinology & Metabolism

Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia

Shi-Young Park et al.

JOURNAL OF PINEAL RESEARCH (2010)

Article Multidisciplinary Sciences

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

Xiaoxia Z. West et al.

NATURE (2010)

Review Environmental Sciences

The Essential Toxin: Impact of Zinc on Human Health

Laura M. Plum et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2010)

Article Critical Care Medicine

DEFEROXAMINE MIMICS THE PATTERN OF HYPOXIA-RELATED INJURY AT THE MICROVASCULATURE

Sonja Bartolome et al.

SHOCK (2009)

Article Endocrinology & Metabolism

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

Emma C. Walker et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2008)

Article Medicine, Research & Experimental

The hypoxia-inducible factor a pathway couples angiogenesis to osteogenesis during skeletal development

Ying Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Cell Biology

EGF-ERBB signalling: towards the systems level

Ami Citri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Dentistry, Oral Surgery & Medicine

Cbfa1 couples chondrocytes maturation and endochondral ossification in rat mandibular condylar cartilage

ABM Rabie et al.

ARCHIVES OF ORAL BIOLOGY (2004)

Article Orthopedics

Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)

HW Cheng et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2003)

Article Cell Biology

Hypoxia is a major stimulator of osteoclast formation and bone resorption

TR Arnett et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2003)

Review Cell Biology

HIF-1 and mechanisms of hypoxia sensing

GL Semenza

CURRENT OPINION IN CELL BIOLOGY (2001)