The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities

Article Cell Biology

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

Karolina Strnadova et al.

Summary: Melanoma-produced exosomes can significantly stimulate the proinflammatory activity of cancer-associated fibroblasts, potentially representing a novel target for oncologic therapy.

HISTOCHEMISTRY AND CELL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Martin Vokurka et al.

Summary: This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts, discussing their significance and therapeutic potential in the dialogue between cancer cells and the tumor microenvironment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

A phase II study of sequential decitabine and rapamycin in acute myelogenous leukemia

Jane L. Liesveld et al.

Summary: The phase II study aimed to investigate whether sequential exposure to decitabine followed by rapamycin would result in better responses in AML patients. Despite not meeting its primary endpoint, the survival rates in relapsed/refractory cases seem comparable to other salvage regimens, and the de novo group had a significantly higher composite CR rate compared to decitabine alone.

LEUKEMIA RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Roles of the CXCL8-CXCR1/2 Axis in the Tumor Microenvironment and Immunotherapy

Zhi-Jian Han et al.

Summary: Interleukin-8 (IL-8 or CXCL8) plays multiple roles within the tumor microenvironment (TME), affecting various components of TME and influencing tumor progression and therapeutic resistance. CXCL8 could be used as a prognostic biomarker and targeting the CXCL8-CXCR1/2 axis shows promise in improving antitumor efficacy. Understanding the interactions between TME components and the CXCL8-CXCR1/2 axis is important for developing novel immunotherapy strategies.

MOLECULES (2022)

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Review Biochemistry & Molecular Biology

A comprehensive review on anticancer mechanism of bazedoxifene

Erum Zafar et al.

Summary: BZA, a synthetic selective estrogen receptor modulator, has shown promising anticancer activity in various cancers through inhibiting multiple signaling pathways and inducing apoptosis, as well as enhancing the efficacy of chemotherapeutic drugs in clinical studies.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

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Review Cell Biology

Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy-An Integrated View into Other Neoplasms and Chemokine Networks

Anca Filimon et al.

Summary: Cutaneous melanoma, accounting for a small percentage of skin cancers but causing the majority of deaths, has unique mutations and capabilities to evade immune control. Interleukin-8 (IL-8) plays a significant role in advanced melanomas and operates in orchestrated programs within signaling webs. Understanding the molecular mechanisms of IL-8's impact on immune cells is crucial for changing the fate of tumors. Further scientific exploration of IL-8's targets in the therapeutic management of melanoma is of great importance.

CELLS (2022)

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Article Oncology

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

Yared Hailemichael et al.

Summary: Immune checkpoint blockade therapy can cause immune-related adverse events. IL-6 expression is higher in colitis and Th17 cells are more prevalent in immune-related enterocolitis. Anti-CTLA-4 induces stronger Th17 memory in colitis than anti-PD-1. In mouse models, IL-6 blockade enhances tumor control and increases CD4(+)/CD8(+) effector T cell density, while reducing Th17, macrophages, and myeloid cells. Combined IL-6 blockade and ICB enhances tumor rejection and mitigates EAE symptoms. IL-6 blockade with ICB can decouple autoimmunity from antitumor immunity.

CANCER CELL (2022)

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Article Biochemistry & Molecular Biology

Interleukin-8: An evolving chemokine

Kouji Matsushima et al.

Summary: This article introduces the research history and related findings of interleukin-8 (IL-8), including the role of IL-8 in inflammation and cancer, as well as its potential as a therapeutic target.

CYTOKINE (2022)

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Review Gastroenterology & Hepatology

Effectiveness and Safety of Tofacitinib for Ulcerative Colitis Systematic Review and Meta-analysis

Vikas Taneja et al.

Summary: This systematic review and meta-analysis evaluated the effectiveness and safety of tofacitinib in treating moderate-severe ulcerative colitis (UC). Results showed that tofacitinib had good efficacy in inducing remission and clinical response, but higher doses were associated with an increased frequency of adverse events. The clinical response rate after tofacitinib induction was similar in biologic naive and biologic experienced patients.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2022)

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Review Biochemistry & Molecular Biology

Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies

Luis M. Montano et al.

Summary: Theophylline is a potential adjuvant in the treatment of COVID-19 patients, as it down-regulates the inflammatory processes activated by the virus through various mechanisms. Computational simulation studies have been used to explore its applications and effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pharmacology & Pharmacy

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

Bilal Rah et al.

Summary: The JAK/STAT signaling pathway plays an important role in regulating cellular processes such as immune regulation, cell proliferation, survival, apoptosis, and hematopoiesis. Dysregulation of this pathway is associated with various immunological disorders, hematological diseases, and solid malignancies. Understanding the intricate mechanisms of JAK/STAT signaling in solid malignancies is crucial for drug development and improving cancer therapies.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Hematology

Ruxolitinib versus best available therapy in inadequately controlled polycythaemia vera without splenomegaly (RESPONSE-2): 5-year follow up of a randomised, phase 3b study

Francesco Passamonti et al.

Summary: The 5-year results of the RESPONSE-2 study support the use of ruxolitinib as a second-line therapy for patients with inadequately controlled polycythaemia vera without splenomegaly.

LANCET HAEMATOLOGY (2022)

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Review Oncology

IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment

Sara G. Manore et al.

Summary: Breast cancer, the most commonly diagnosed cancer in women, often metastasizes due to the IL-6-mediated signaling pathway. Abnormal activation of this pathway promotes breast cancer metastasis while suppressing the anti-tumor immune response. Components of the IL-6 pathway are potential targets for cancer therapeutics.

FRONTIERS IN ONCOLOGY (2022)

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Article Cell Biology

Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation

Peter Gal et al.

Summary: Recent evidence suggests that targeting IL-6 is a promising therapeutic approach for various diseases. Comparing the effects of IL-6 and anti-IL-6 therapy can help identify common features of these diseases.

HISTOCHEMISTRY AND CELL BIOLOGY (2022)

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Article Oncology

Overall survival in the SIMPLIFY-1 and SIMPLIFY-2 phase 3 trials of momelotinib in patients with myelofibrosis

Ruben Mesa et al.

Summary: JAK inhibitors are effective for myelofibrosis, but do not address anemia. Momelotinib, targeting ACVR1/ALK2, JAK1 and JAK2, shows activity against anemia, symptoms, and splenomegaly.

LEUKEMIA (2022)

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Article Biochemistry & Molecular Biology

Targeting mitochondrial metabolism for metastatic cancer therapy

Antonino Passaniti et al.

Summary: Tumors and metastatic cells have different preferences in energy metabolism, and drugs targeting mitochondrial metabolism may have therapeutic effects on metastatic cells. This review provides a mechanistic analysis of using drugs that enhance reactive oxygen species (ROS) production or reduce antioxidant defenses to increase oxidative stress and inhibit tumor cell survival. It also discusses the rationale for targeting ERK and mitochondrial respiration as therapeutic strategies to reduce tumor metastasis and treatment resistance.

MOLECULAR CARCINOGENESIS (2022)

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Review Immunology

Efficacy and safety of ruxolitinib in steroid-refractory graft-versus-host disease: A meta-analysis

Shuang Fan et al.

Summary: This study reports the updated results of ruxolitinib as treatment for SR-GVHD and compares the efficacy and safety between children and adults. The findings suggest that ruxolitinib is an effective and safe treatment for SR-GVHD, and both children and adults can benefit from it.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

The Androgen Receptor and Its Crosstalk With the Src Kinase During Castrate-Resistant Prostate Cancer Progression

Lin Gao et al.

Summary: Prostate tumor cells have the ability to bypass their dependency on androgens and/or androgen receptor (AR) signaling, leading to therapy resistance. Src kinase plays a crucial role in promoting prostate tumor progression. Although Src inhibitors have been used in clinical trials for castrate-resistant prostate tumors, their efficacy remains limited and further investigation is needed.

FRONTIERS IN ONCOLOGY (2022)

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Article Medicine, Research & Experimental

Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration

Jindriska Leischner Fialova et al.

Summary: Mitochondria play a crucial role in cellular growth and function, and recent studies have challenged the notion that they are not involved in cancer growth. This study shows that pentamethinium salts, originally designed as mitochondrial probes, have a strong inhibitory effect on cancer cell proliferation and migration by interfering with mitochondrial respiration and causing oxidative stress. These findings suggest that pentamethinium salts could be potential novel anti-cancer agents.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Pharmacology & Pharmacy

New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity

Veronika Talianova et al.

Summary: IL-6 signaling plays a crucial role in the pathogenesis of serious diseases such as chronic inflammation and cancer. Two newly designed bis-pentamethinium salts compounds showed potential in binding IL-6 receptor and inhibiting mitochondrial metabolism in cancer cells.

PHARMACEUTICS (2022)

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Review Medicine, Research & Experimental

Interleukin Inhibitors in Cytokine Release Syndrome and Neurotoxicity Secondary to CAR-T Therapy

Puri Ferreros et al.

Summary: This study examined the efficacy of interleukin inhibitors in addressing cytokine release syndrome and neurotoxicity secondary to CAR-T therapy. Tocilizumab was found to be the only approved interleukin inhibitor for treating CRS secondary to CAR-T therapy, while other inhibitors like siltuximab and anakinra could be useful in combination with tocilizumab to prevent severe cytokine release and neurotoxicity. New specific inhibitors may also be effective in mitigating CRS without compromising the cytotoxic efficacy of CAR-T therapy.

DISEASES (2022)

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Article Gastroenterology & Hepatology

Targeting interleukin 6 signaling by monoclonal antibody siltuximab on cholangiocarcinoma

Mai Ly Thi Nguyen et al.

Summary: The study revealed the oncogenic potential of IL-6 in cholangiocarcinoma, with siltuximab effectively inhibiting IL-6 signaling and preventing cancer progression. This suggests the essential role of IL-6 in cholangiocarcinoma carcinogenesis and the potential of siltuximab as a new treatment option for patients with this type of cancer.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Hematology

A phase 3 double-blind study of the addition of tocilizumab vs placebo to cyclosporin/methotrexate GVHD prophylaxis

Glen A. Kennedy et al.

Summary: The use of tocilizumab showed trends towards reducing the incidence of grade 2-4 aGVHD in recipients, but did not significantly improve long-term survival outcomes.

BLOOD (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Biochemistry & Molecular Biology

The implication of IL-6 in the invasiveness and chemoresistance of ovarian cancer cells. Systematic review of its potential role as a biomarker in ovarian cancer patients

Izabela Szulc-Kielbik et al.

Summary: IL-6 plays multiple roles in ovarian cancer, including promoting cell proliferation, inhibiting apoptosis, enhancing cell migration and invasion, and correlating with chemotherapy resistance. Its elevated levels in serum and ascites of ovarian cancer patients suggest it as a potential biomarker for distinguishing malignant and nonmalignant tumors and predicting chemotherapy response. IL-6 also serves as a potential target in anti-cancer therapy.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Review Cell Biology

IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy

Rebekka Weber et al.

Summary: MDSC are crucial cells generated during tumor progression that suppress the anti-tumor functions of T and NK cells. IL-6 plays a key role in regulating the accumulation and activation of MDSC, as well as stimulating tumor cell proliferation and survival. This cytokine has pleiotropic effects on immune cell populations involved in tumor development and is a potential target for tumor immunotherapy to block MDSC-mediated immunosuppression in cancer patients.

CELLULAR IMMUNOLOGY (2021)

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Article Virology

Nonsteroidal Anti-inflammatory Drugs Dampen the Cytokine and Antibody Response to SARS-CoV-2 Infection

Jennifer S. Chen et al.

Summary: Research has shown that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the inflammatory response and antibody production in SARS-CoV-2 infection treatment, without affecting susceptibility to infection or viral replication.

JOURNAL OF VIROLOGY (2021)

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Review Chemistry, Medicinal

Novel Mitochondria-targeted Drugs for Cancer Therapy

Jindriska Leischner Fialova et al.

Summary: The search for mitochondria-targeted drugs has increased significantly in the past decade, as mitochondria play crucial roles in cell function and life processes, with important implications for cancer pharmacology.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives

Michal Spanko et al.

Summary: Interleukin-6 (IL-6) is a potent cytokine involved in various biological processes, with distinct roles in inflammation, autoimmune diseases, and cancer. IL-6 and its signaling pathways play significant roles in orchestrating the cancer microenvironment, making them potential targets for anti-tumor therapy. This article aims to elucidate the role of IL-6 in the tumor ecosystem and review potential therapeutic approaches in head and neck cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms

Jan Korbecki et al.

Summary: This paper discusses the mechanisms and effects of chronic low-grade inflammation caused by chronic hypoxia and cycling hypoxia in malignant tumors, as well as their impact on the tumor microenvironment and cell recruitment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Inhibition of STAT3 augments antitumor efficacy of anti-CTLA-4 treatment against prostate cancer

Kristina Witt et al.

Summary: The combination of STAT3 inhibition with anti-CTLA-4 therapy enhances antitumoral activity in prostate cancer, reducing intratumoral Treg frequency.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

The Anti-Cancer Effects of a Zotarolimus and 5-Fluorouracil Combination Treatment on A549 Cell-Derived Tumors in BALB/c Nude Mice

Ching-Feng Wu et al.

Summary: The study showed that the treatment with Zotarolimus or Zotarolimus combined with 5-FU significantly inhibited lung adenocarcinoma growth, increased tumor cell apoptosis, reduced inflammation levels, and inhibited tumor metastasis. The synergistic anti-tumor effect of Zotarolimus and 5-FU on lung adenocarcinoma was evident, with the combination treatment being more effective than using 5-FU or Zotarolimus alone.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Medicine, General & Internal

Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression-3PM pathways

Peter Kubatka et al.

Summary: Inflammation plays a crucial role in immune defense, while chronic inflammation is considered a hallmark of cancer initiation and progression. Flavonoids, with their anti-inflammatory activities, have the potential to be preventive and therapeutic agents in diseases linked to chronic inflammation, including cancer. Individualized profiling and patient stratification are essential for implementing targeted anti-inflammatory approaches in overall cancer management.

EPMA JOURNAL (2021)

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Review Pharmacology & Pharmacy

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Zdenek Kejik et al.

Summary: Designing optimal adjuvant therapy is crucial in treating non-small-cell lung carcinoma. Standard methods may not be effective in cases with high level of CTCs, thus alternative therapeutic strategies like low-toxicity natural agents may be considered when standard methods fail. This review discusses NSCLC therapy strategies and potential options for treatment beyond standard methods.

PHARMACEUTICS (2021)

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Review Genetics & Heredity

Up-down regulation of HIF-1α in cancer progression

Mohsen Rashid et al.

Summary: Hypoxia inducible factor-1 alpha (HIF-1 alpha) plays a crucial role in cancer progression, functioning differently in cells depending on oxygen levels. Targeting HIF-1 alpha and its downstream signaling molecules is a potential strategy for modulating cancer development and progression. Inhibitors of HIF-1 alpha and agents that suppress mTOR, PI3k/Akt, and MAPK pathways could be effective in cancer treatment.

GENE (2021)

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Article Biochemistry & Molecular Biology

Bazedoxifene, a GP130 Inhibitor, Modulates EMT Signaling and Exhibits Antitumor Effects in HPV-Positive Cervical Cancer

Leekyung Kim et al.

Summary: This study investigated the anticancer properties of Bazedoxifene in HPV-positive cervical cancer cells, demonstrating its ability to inhibit cell growth and metastasis. Bazedoxifene exerts its anticancer effects by suppressing the GP130/STAT3 pathway and the EMT sub-signal.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Medicinal

Research progress of phenolic compounds regulating IL-6 to exert antitumor effects

Tingting Xia et al.

Summary: Cytokine therapy, focusing on the regulation of IL-6, shows potential as a novel approach in cancer treatment, but more high-quality clinical studies are needed to validate its efficacy.

PHYTOTHERAPY RESEARCH (2021)

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Review Multidisciplinary Sciences

Low-dose theophylline in addition to ICS therapy in COPD patients: A systematic review and meta-analysis

Tiankui Shuai et al.

Summary: The study investigated the efficacy of low-dose theophylline as add-on therapy to inhaled corticosteroids in COPD. Results showed that theophylline did not reduce COPD exacerbations but instead increased hospitalization and mortality rates.

PLOS ONE (2021)

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Article Oncology

IL-6 contributes to metastatic switch via the differentiation of monocytic-dendritic progenitors into prometastatic immune cells

Ksenia Magidey-Klein et al.

Summary: Our study uncovers a new role for tumor-derived IL-6 in promoting the differentiation of HSPCs into prometastatic MDPs, which further differentiate into immunosuppressive monocytes to facilitate the metastatic process.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Cell Biology

Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines

Mykyta Malkov et al.

Summary: Hypoxia and inflammation frequently co-occur in inflammatory diseases, with pro-inflammatory cytokines such as TNF-alpha and IL-1 beta directly impacting HIF signaling pathways. Multi-level crosstalk between inflammatory and hypoxic signaling pathways plays a crucial role in shaping the degree of inflammation at hypoxic sites.

CELLS (2021)

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Review Oncology

Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors

Sayani Patra et al.

Summary: Recent studies have shown that metabolic heterogeneity occurs at various levels within tumors, impacting tumor progression and response to treatment. Understanding the complex interactions between metabolic properties, oncogenes, and the tumor microenvironment is crucial for developing more effective personalized treatments for cancer patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Desmoplastic Crosstalk in Pancreatic Ductal Adenocarcinoma Is Reflected by Different Responses of Panc-1, MIAPaCa-2, PaTu-8902, and CAPAN-2 Cell Lines to Cancer-associated/Normal Fibroblasts

Stepan Novak et al.

Summary: PDAC cell lines exhibit various responses to conditioned media derived from CAFs, with Panc-1 cells showing the most aggressive behavior and PaTu-8902 cells being inhibited. The heterogeneity in response highlights the complex tumor-stromal interactions that contribute to the aggressive behavior of PDAC.

CANCER GENOMICS & PROTEOMICS (2021)

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Letter Biochemistry & Molecular Biology

Invasion and metastasis: the elusive hallmark of cancer

Tomer Meirson et al.

ONCOGENE (2020)

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Review Biochemistry & Molecular Biology

Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer

Stepana Boukalova et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

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Article Oncology

Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2

Jiri Novotny et al.

CANCERS (2020)

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Letter Biotechnology & Applied Microbiology

Visualizing and interpreting cancer genomics data via the Xena platform

Mary J. Goldman et al.

NATURE BIOTECHNOLOGY (2020)

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Article Oncology

IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma

Rebekka Weber et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Medicine, General & Internal

Head and neck squamous cell carcinoma

Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Review Biochemistry & Molecular Biology

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

Jan Brabek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

STAT3 isoforms: Alternative fates in cancer?

Petra Aigner et al.

CYTOKINE (2019)

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Review Biochemistry & Molecular Biology

STAT3beta, a distinct isoform from STAT3

Hui-Xiang Zhang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Review Oncology

Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications

Claudia Peitzsch et al.

CANCERS (2019)

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Review Oncology

Current state of melanoma diagnosis and treatment

Lauren E. Davis et al.

CANCER BIOLOGY & THERAPY (2019)

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Article Clinical Neurology

Rapamycin alleviates proinflammatory cytokines and nociceptive behavior induced by chemotherapeutic paclitaxel

Xiaoli Zhang et al.

NEUROLOGICAL RESEARCH (2019)

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Review Cell Biology

Mitochondrial Involvement in Migration, Invasion and Metastasis

Tatiana Denisenko et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

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Review Immunology

MDSCs: Key Criminals of Tumor Pre-metastatic Niche Formation

Yungang Wang et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Dentistry, Oral Surgery & Medicine

Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma

Feng Liao et al.

ARCHIVES OF ORAL BIOLOGY (2018)

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Article Oncology

Hypoxia-induced HMGB1 expression of HCC promotes tumor invasiveness and metastasis via regulating macrophage-derived IL-6

Jiang Jiang et al.

EXPERIMENTAL CELL RESEARCH (2018)

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Review Oncology

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

Daniel E. Johnson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Cell Biology

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

Dongya Jia et al.

CELLS (2018)

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Article Oncology

The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models

Florian Handle et al.

MOLECULAR CANCER THERAPEUTICS (2018)

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Article

Tumor cell density regulates matrix metalloproteinases for enhanced migration

Hasini Jayatilaka et al.

Oncotarget (2018)

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Review Oncology

IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis

Landon Browning et al.

CANCER MANAGEMENT AND RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target

U. Saini et al.

ONCOGENE (2017)

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Article Cell Biology

An autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells

Deyong Jia et al.

CELL DEATH & DISEASE (2017)

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Article Multidisciplinary Sciences

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Hasini Jayatilaka et al.

NATURE COMMUNICATIONS (2017)

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Article Oncology

Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels

Hong Sun Kim et al.

ONCOTARGET (2017)

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Article Hematology

A single center phase II study of ixazomib in patients with relapsed or refractory cutaneous or peripheral T-cell lymphomas

Philip S. Boonstra et al.

AMERICAN JOURNAL OF HEMATOLOGY (2017)

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Article Oncology

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

Aneta Gandalovicova et al.

TRENDS IN CANCER (2017)

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Review Oncology

Pre-metastatic niches: organ-specific homes for metastases

Hector Peinado et al.

NATURE REVIEWS CANCER (2017)

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Article Rheumatology

Tofacitinib, an oral Janus kinase inhibitor: analysis of malignancies across the rheumatoid arthritis clinical development programme

Jeffrey R. Curtis et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

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Article Oncology

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre-metastatic Niche

Amber Jin Giles et al.

CANCER RESEARCH (2016)

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Article Oncology

Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy

M. Cecilia Caino et al.

CLINICAL CANCER RESEARCH (2016)

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Article Oncology

IL-1β induces IL-6 production and increases invasiveness and estrogen-independent growth in a TG2-dependent manner in human breast cancer cells

Keunhee Oh et al.

BMC CANCER (2016)

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Article Oncology

IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma

Yuichiro Matsuoka et al.

BRITISH JOURNAL OF CANCER (2016)

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Article Nutrition & Dietetics

Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans

Ying Hu et al.

BRITISH JOURNAL OF NUTRITION (2016)

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Article Cell Biology

Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness

Njainday Pulo Jobe et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2016)

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Article Chemistry, Medicinal

Preclinical Characterization of 3β-(N-Acetyl L-cysteine methyl ester)-2aβ,3-dihydrogaliellalactone (GPA512), a Prodrug of a Direct STAT3 Inhibitor for the Treatment of Prostate Cancer

Zilma Escobar et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Oncology

Malignant ascites enhances migratory and invasive properties of ovarian cancer cells with membrane bound IL-6R in vitro

Soochi Kim et al.

ONCOTARGET (2016)

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Article Cell Biology

Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer

Pradeep Chaluvally-Raghavan et al.

CELL REPORTS (2016)

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Article Oncology

A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer

E. M. Dijkgraaf et al.

ANNALS OF ONCOLOGY (2015)

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Review Oncology

Tumors and Mitochondrial Respiration: A Neglected Connection

Andrea Viale et al.

CANCER RESEARCH (2015)

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Article Oncology

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies

Michinori Ogura et al.

CANCER SCIENCE (2015)

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Article Oncology

Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling

Yuefeng Du et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Article Oncology

Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma

Aditya Stanam et al.

MOLECULAR ONCOLOGY (2015)

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Article Oncology

Interleukin-6 and pro inflammatory status in the breast tumor microenvironment

Alessandro Sanguinetti et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2015)

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Article Oncology

Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma

Daiki Mochizuki et al.

ONCOTARGET (2015)

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Article Oncology

Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors

Do-Youn Oh et al.

CANCER RESEARCH AND TREATMENT (2015)

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Article Otorhinolaryngology

Cancer stem cells: Mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma

Steven B. Chinn et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2015)

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Article Oncology

Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors

Johanna C. Bendell et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2014)

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Article Oncology

Cell type specific interleukin-6 induced responses in tumor keratinocytes and stromal fibroblasts are essential for invasive growth

Sofia Depner et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

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Article Chemistry, Medicinal

Adjuvant Therapy with Bioavailability-Boosted Curcuminoids Suppresses Systemic Inflammation and Improves Quality of Life in Patients with Solid Tumors: A Randomized Double-Blind Placebo-Controlled Trial

Yunes Panahi et al.

PHYTOTHERAPY RESEARCH (2014)

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Article Cell & Tissue Engineering

Endothelial Interleukin-6 Defines the Tumorigenic Potential of Primary Human Cancer Stem Cells

Sudha Krishnamurthy et al.

STEM CELLS (2014)

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Article Cell Biology

IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function

Jan P. Boettcher et al.

CELL REPORTS (2014)

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Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

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Article Oncology

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

Mi-Jung Kim et al.

CANCER LETTERS (2013)

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Article Oncology

Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment

Eveline M. Dijkgraaf et al.

CANCER RESEARCH (2013)

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Article Oncology

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

Thomas A. Mace et al.

CANCER RESEARCH (2013)

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Article Biochemistry & Molecular Biology

Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727

Qifang Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Oncology

Possible Role for Tocilizumab, an Anti-Interleukin-6 Receptor Antibody, in Treating Cancer Cachexia

Katsutoshi Ando et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

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Article Oncology

Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6

Abulimiti Abulaiti et al.

LUNG CANCER (2013)

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Article Oncology

Mechanism of the inhibition of the STAT3 signaling pathway by EGCG

Yang Wang et al.

ONCOLOGY REPORTS (2013)

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Article Multidisciplinary Sciences

Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice

Gerardo G. Mackenzie et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

The Ratios of CD8+ T Cells to CD4+ CD25+ FOXP3+ and FOXP3- T Cells Correlate with Poor Clinical Outcome in Human Serous Ovarian Cancer

Claudia C. Preston et al.

PLOS ONE (2013)

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Article Oncology

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

Qing Chang et al.

NEOPLASIA (2013)

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Article Hematology

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

Charlie Mantel et al.

BLOOD (2012)

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Article Biochemistry & Molecular Biology

Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells

Yue Wang et al.

CYTOKINE (2012)

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Review Biochemistry & Molecular Biology

Inflammation and ovarian cancer

Antonio Maccio et al.

CYTOKINE (2012)

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Review Biochemistry & Molecular Biology

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

Stefan Rose-John

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

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Article Oncology

Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma

Makoto Adachi et al.

ORAL ONCOLOGY (2012)

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Review Biochemistry & Molecular Biology

The pro- and anti-inflammatory properties of the cytokine interleukin-6

Juergen Scheller et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

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Article Oncology

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

Marina Lesina et al.

CANCER CELL (2011)

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Article Oncology

Lung Cancer Chemoprevention with Celecoxib in Former Smokers

Jenny T. Mao et al.

CANCER PREVENTION RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Review Cell Biology

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

Athena Chalaris et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2011)

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Article Oncology

Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells

Jacqueline A. Gasche et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

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Review Biotechnology & Applied Microbiology

Initial steps of metastasis: Cell invasion and endothelial transmigration

Franziska van Zijl et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2011)

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Article Oncology

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

James E. Talmadge et al.

CANCER RESEARCH (2010)

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Review Oncology

Current trends and future perspectives in the surgical management of oral cancer

Nicholas Kalavrezos et al.

ORAL ONCOLOGY (2010)

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Article Oncology

The invasive potential of human melanoma cell lines correlates with their ability to alter fibroblast gene expression in vitro and the stromal microenvironment in vivo

Ling Li et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

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Article Biochemistry & Molecular Biology

Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells

N. J. Sullivan et al.

ONCOGENE (2009)

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Article Multidisciplinary Sciences

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

Daniel J. Gough et al.

SCIENCE (2009)

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Article Multidisciplinary Sciences

Function of Mitochondrial Stat3 in Cellular Respiration

Joanna Wegrzyn et al.

SCIENCE (2009)

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Review Oncology

STATs in cancer inflammation and immunity: a leading role for STAT3

Hua Yu et al.

NATURE REVIEWS CANCER (2009)

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Article Oncology

Phase II trial of curcumin in patients with advanced pancreatic cancer

Navneet Dhillon et al.

CLINICAL CANCER RESEARCH (2008)

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Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)

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Article Endocrinology & Metabolism

Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3

Rebecka Hellsten et al.

PROSTATE (2008)

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Article Allergy

3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit:: Potential clinical implications

Tomoshige Kino et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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Review Immunology

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment

Hua Yu et al.

NATURE REVIEWS IMMUNOLOGY (2007)

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Article Pharmacology & Pharmacy

Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: A mechanism of tumor growth inhibition

Hyunsung Choi et al.

MOLECULAR PHARMACOLOGY (2006)

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Review Cell Biology

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

Stefan Rose-John et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2006)

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Article Multidisciplinary Sciences

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

RN Kaplan et al.

NATURE (2005)

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Article Biochemistry & Molecular Biology

Binding of Madindoline A to the extracellular domain of gp130

AZM Saleh et al.

BIOCHEMISTRY (2005)

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Article Multidisciplinary Sciences

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation

RM McLoughlin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Review Biochemistry & Molecular Biology

Mammalian pyrimidine biosynthesis: Fresh insights into an ancient pathway

DR Evans et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Plant Sciences

Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells

A Enomoto et al.

JOURNAL OF NATURAL PRODUCTS (2004)

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Article Multidisciplinary Sciences

Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130

M Hayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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Article Pharmacology & Pharmacy

Biological activity of a novel nonpeptide antagonist to the interleukin-6 receptor 20S,21-epoxy-resibufogenin-3-formate

M Hayashi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

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Article Otorhinolaryngology

Clinical significance of interleukin-6 and interleukin-6 receptor expressions in oral squamous cell carcinoma

YF Wang et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2002)

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Article Pharmacology & Pharmacy

Theophylline inhibits NF-κB activation and IκBα degradation in human pulmonary epithelial cells

T Ichiyama et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2001)

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Article Biochemistry & Molecular Biology

Reduction in serum IL-6 after vacination of breast cancer patients with tumour-associated antigens is related to estrogen receptor status

XP Jiang et al.

CYTOKINE (2000)

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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities

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