Journal
CELLS
Volume 11, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/cells11223698
Keywords
IL-6; cancer; metastasis
Categories
Funding
- Operational Programme Research, Development and Education, within the projects: Centre for Tumour Ecology-Research of the Cancer Microenvironment Supporting Cancer Growth and Spread [CZ.02.1.01/0.0/0.0/16_019/0000785]
- European Union-Next Generation EU [LX22NPO5102]
- Ministry of Education, Youth and Sports [LM2018133]
- Ministry of Health of the Czech Republic [NU21-08-00407, NU22-D-136]
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This review summarizes the role of interleukin 6 (IL-6) in cancer biology, highlighting the potential of targeting IL-6 signaling pathways, particularly in metastasis suppression.
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-kappa B) is an intensively studied approach in preclinical cancer research. It is of significant translational potential; numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.
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