Journal
CELLS
Volume 11, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/cells11233900
Keywords
MALDI MSI; Mass spectrometry imaging; microbiology; biomarkers; microbial interactions; diagnostics; drug distribution
Categories
Funding
- Luxembourg National Research Fund (FNR): BRIDGES project
- [15415867]
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MALDI-TOF MS is widely used in microbiology for identification, but requires further upgrades. MSI is popular in life sciences and can detect biomolecules while showing their spatial distribution.
Nowadays, matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) is routinely implemented as the reference method for the swift and straightforward identification of microorganisms. However, this method is not flawless and there is a need to upgrade the current methodology in order to free the routine lab from incubation time and shift from a culture-dependent to an even faster independent culture system. Over the last two decades, mass spectrometry imaging (MSI) gained tremendous popularity in life sciences, including microbiology, due to its ability to simultaneously detect biomolecules, as well as their spatial distribution, in complex samples. Through this literature review, we summarize the latest applications of MALDI-MSI in microbiology. In addition, we discuss the challenges and avenues of exploration for applying MSI to solve current MALDI-TOF MS limits in routine and research laboratories.
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