Molecular Immunology in Bacterial Vaccine Discovery

Article Microbiology

PGRS domain structures: Doomed to sail the mycomembrane

Rita Berisio et al.

Summary: The impact of artificial intelligence in understanding biological processes is potentially enormous, particularly in structural elucidation such as the case of mycobacterial PE_PGRS. The proposed PGRS sailing model serves as a smart tool to diffuse along the mycomembrane, exposing structural motifs for host interactions, and shipping functional protein modules at their C-terminus.

PLOS PATHOGENS (2022)

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Review Cell Biology

PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response

Eliza Kramarska et al.

Summary: PE_PGRS proteins are surface antigens of Mycobacterium tuberculosis and can interact with host receptors. Understanding the structure of PE_PGRS33, particularly its PGRS domain, may lead to new vaccination strategies against TB. By targeting specific features of the PGRS domain, such as exposed PGII sandwiches, a humoral response could be induced for potential vaccine development.

CELLS (2021)

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Review Cell Biology

Developing New Anti-Tuberculosis Vaccines: Focus on Adjuvants

Ana Rita Franco et al.

Summary: Tuberculosis is a major global health concern, and new vaccines are needed to overcome the limitations of the current BCG vaccine. The World Health Organization considers the development of new TB vaccines to be a top priority, with subunit vaccines being promising candidates that may require adjuvants to enhance their efficacy.

CELLS (2021)

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Review Cell Biology

Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines

Megan E. Grund et al.

Summary: The review focuses on Burkholderia vaccine candidates derived from outer membrane proteins, including OmpA, OmpW, Omp85, and Bucl8, discussing their structures, conservation, and vaccine formulation.

CELLS (2021)

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Review Pharmacology & Pharmacy

Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation

Virgil Schijns et al.

Summary: Vaccines are crucial in preventing infections and improving mortality rates worldwide, and rational design of vaccines can enhance their efficacy. Understanding immune correlates of protection is key in selecting the best vaccine antigens and adjuvants for optimal immune responses. Harnessing this knowledge is imperative in preventing future life-threatening diseases.

PHARMACEUTICS (2021)

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Review Cell Biology