4.6 Article

Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

Low and high doses of ionizing radiation evoke discrete global (phospho) proteome responses

Bharath Sampadi et al.

Summary: This study investigated the proteomic and phosphoproteomic responses to low doses (LD) and high doses (HD) of ionizing radiation (IR) using mouse embryonic stem cells. The results showed distinct global proteome and phosphoproteome responses to LD and HD, with different proteins and phosphorylation events involved. LD primarily affected mitochondrial metabolic proteins and pathways, while HD mainly affected transporter proteins and mitochondrial uncoupling pathways. The phosphoproteomic response to LD occurred earlier and was mainly associated with reactive oxygen species (ROS) production, while the response to HD was related to DNA damage response (DDR) activation.

DNA REPAIR (2022)

Article Cell Biology

Phosphoproteomics Sample Preparation Impacts Biological Interpretation of Phosphorylation Signaling Outcomes

Bharath Sampadi et al.

Summary: The influence of phosphoproteomics sample preparation methods on the biological interpretation of signaling outcome is unclear. Two commonly used methods show a strong bias in phosphorylation signaling targets, each method has advantages in analyzing IR-responsive phosphoproteins, and they respectively reveal different phosphorylation signaling events.

CELLS (2021)

Editorial Material Public, Environmental & Occupational Health

The Increasing Exposure of the Global Population to Ionizing Radiation

Alberto Ruano-Ravina et al.

EPIDEMIOLOGY (2020)

Review Cell Biology

Target gene-independent functions of MYC oncoproteins

Apoorva Baluapuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Cell Biology

ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

Winnie Tan et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Involvement of Wnt signaling in primary cilia assembly and disassembly

Kyung Ho Lee

FEBS JOURNAL (2020)

Review Cell Biology

The Complex Interplay between Antioxidants and ROS in Cancer

Isaac S. Harris et al.

TRENDS IN CELL BIOLOGY (2020)

Article Cell Biology

Mesenchymal Stem Cells Early Response to Low-Dose Ionizing Radiation

Marina Konkova et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

Pia-Amata Leimbacher et al.

MOLECULAR CELL (2019)

Article Multidisciplinary Sciences

Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase

Steffi Herold et al.

NATURE (2019)

Article Medicine, General & Internal

Radiotherapy toxicity

Dirk De Ruysscher et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Article Cell & Tissue Engineering

Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

David Fernandez-Antoran et al.

CELL STEM CELL (2019)

Article Biochemistry & Molecular Biology

Negative feedback via RSK modulates Erk-dependent progression from naive pluripotency

Isabelle R. E. Nett et al.

EMBO REPORTS (2018)

Article Biochemistry & Molecular Biology

Four Key Steps Control Glycolytic Flux in Mammalian Cells

Lukas Bahati Tanner et al.

CELL SYSTEMS (2018)

Article Biochemistry & Molecular Biology

Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6

Yuguang Zhao et al.

FEBS LETTERS (2018)

Review Biochemistry & Molecular Biology

Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis

Vladimir Joukov et al.

SCIENCE SIGNALING (2018)

Article Biochemistry & Molecular Biology

PP2ACdc55 Phosphatase Imposes Ordered Cell- Cycle Phosphorylation by Opposing Threonine Phosphorylation

Molly Godfrey et al.

MOLECULAR CELL (2017)

Review Biochemistry & Molecular Biology

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

Andrew N. Blackford et al.

MOLECULAR CELL (2017)

Review Genetics & Heredity

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

Herve Techer et al.

NATURE REVIEWS GENETICS (2017)

Article Biochemistry & Molecular Biology

p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics

Antonina Hafner et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Review Biology

A restatement of the natural science evidence base concerning the health effects of low-level ionizing radiation

Angela R. McLean et al.

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)

Article Multidisciplinary Sciences

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

Alex N. Zelensky et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics

Antonina Hafner et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Multidisciplinary Sciences

Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53

Ishwarya Venkata Narayanan et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells

Joost Schimmel et al.

EMBO JOURNAL (2017)

Article Cell & Tissue Engineering

MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux

Timothy S. Cliff et al.

CELL STEM CELL (2017)

Correction Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease (vol 168, pg 960, 2017)

Robert A. Saxton et al.

Article Biochemistry & Molecular Biology

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing

Andrew L. Paek et al.

Article Biochemistry & Molecular Biology

CDK Substrate Phosphorylation and Ordering the Cell Cycle

Matthew P. Swaffer et al.

Article Biochemistry & Molecular Biology

Two Bistable Switches Govern M Phase Entry

Satoru Mochida et al.

CURRENT BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

RS-1 enhances CRISPR/Cas9-and TALEN-mediated knock-in efficiency

Jun Song et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion

Francesca Sacco et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice

Asami Oji et al.

SCIENTIFIC REPORTS (2016)

Article Medicine, General & Internal

Long-term effects of radiation exposure on health

Kenji Kamiya et al.

LANCET (2015)

Article Biochemical Research Methods

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs

Rachael A. McCloy et al.

MOLECULAR & CELLULAR PROTEOMICS (2015)

Article Biochemistry & Molecular Biology

ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress

Yu-Hung Chen et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation

Nelio T. L. Rodrigues et al.

NATURE (2015)

Article Biotechnology & Applied Microbiology

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Van Trung Chu et al.

NATURE BIOTECHNOLOGY (2015)

Article Biotechnology & Applied Microbiology

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

Sean J. Humphrey et al.

NATURE BIOTECHNOLOGY (2015)

Article Biochemistry & Molecular Biology

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors

Andrea J. Hartlerode et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors

Andrea J. Hartlerode et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Multidisciplinary Sciences

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

Bryce W. Carey et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response

R. Lall et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Biotechnology & Applied Microbiology

Quantifying murine bone marrow and blood radiation dose response following (18)FFDG PET with DNA damage biomarkers

Grainne Manning et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2014)

Review Biochemistry & Molecular Biology

Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback

James E. Ferrell et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Letter Medicine, General & Internal

Risk and Risk Reduction of Major Coronary Events Associated With Contemporary Breast Radiotherapy

David J. Brenner et al.

JAMA INTERNAL MEDICINE (2014)

Review Oncology

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Simran S. Sabharwal et al.

NATURE REVIEWS CANCER (2014)

Review Biochemistry & Molecular Biology

Effects of ionizing radiation on mitochondria

Winnie Wai-Ying Kam et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Review Multidisciplinary Sciences

mTOR is a key modulator of ageing and age-related disease

Simon C. Johnson et al.

NATURE (2013)

Review Cell Biology

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Yosef Shiloh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response

Michelle T. Paulsen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Does Nrf2 Contribute to p53-Mediated Control of Cell Survival and Death?

Weimin Chen et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Biochemistry & Molecular Biology

Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

Petra Beli et al.

MOLECULAR CELL (2012)

Article Multidisciplinary Sciences

p53 Dynamics Control Cell Fate

Jeremy E. Purvis et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair

Satyendra K. Singh et al.

NUCLEIC ACIDS RESEARCH (2011)

Review Cell & Tissue Engineering

Concise Review: Stem Cell Effects in Radiation Risk

Kevin M. Prise et al.

STEM CELLS (2011)

Review Biochemistry & Molecular Biology

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Michelle C. Mendoza et al.

TRENDS IN BIOCHEMICAL SCIENCES (2011)

Article Genetics & Heredity

Radiation induced DNA DSBs: Contribution from stalled replication forks?

Jane V. Harper et al.

DNA REPAIR (2010)

Article Biochemical Research Methods

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

Martin V. Bennetzen et al.

MOLECULAR & CELLULAR PROTEOMICS (2010)

Review Biochemistry & Molecular Biology

The DNA Damage Response: Making It Safe to Play with Knives

Alberto Ciccia et al.

MOLECULAR CELL (2010)

Editorial Material Medicine, General & Internal

Medical Imaging in the 21st Century - Getting the Best Bang for the Rad

David J. Brenner

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

Ariel Bensimon et al.

SCIENCE SIGNALING (2010)

Review Multidisciplinary Sciences

The DNA-damage response in human biology and disease

Stephen P. Jackson et al.

NATURE (2009)

Letter Biochemical Research Methods

Improved visualization of protein consensus sequences by iceLogo

Niklaas Colaert et al.

NATURE METHODS (2009)

Article Biochemistry & Molecular Biology

Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq

Iouri Chepelev et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Biochemistry & Molecular Biology

Cellular responses to DNA double-strand breaks after low-dose γ-irradiation

Aroumougame Asaithamby et al.

NUCLEIC ACIDS RESEARCH (2009)

Review Oncology

Assessing cancer risks of low-dose radiation

Leon Mullenders et al.

NATURE REVIEWS CANCER (2009)

Article Multidisciplinary Sciences

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

Jidong Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Shuhei Matsuoka et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

p53 suppresses the Nrf2-dependent transcription of antioxidant response genes

Raffaella Faraonio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated keap1-dependent ubiquitin ligase complex

Shih-Ching Lo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

c-Myc phosphorylation is required for cellular response to oxidative stress

B Benassi et al.

MOLECULAR CELL (2006)

Article Biochemistry & Molecular Biology

Erk associates with and primes GSK-3β for its inactivation resulting in upregulation of β-catenin

QQ Ding et al.

MOLECULAR CELL (2005)

Article Biology

DNA damage responses at low radiation doses

SC Short et al.

RADIATION RESEARCH (2005)

Article Cell Biology

Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2

JR Pomerening et al.

NATURE CELL BIOLOGY (2003)