Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation

As we already reported, fibrinogen fucosylation emerged as a prognostic marker of peritoneal membrane function in end-stage renal disease (ESRD) patients on peritoneal dialysis. After a follow-up period of 18 months, we estimated the ability of employed lectins, as well as other biochemical parameters, to serve as mortality predictors in these patients. Following a univariate Cox regression analysis, ferritin, urea clearance, residual diuresis, hyperglycemia, and an increase in the signal intensity obtained with Galanthus nivalis lectin (GNL) emerged as potential mortality predictors, but additional multivariate Cox regression analysis pointed only to glucose concentration and GNL as mortality predictors. Higher signal intensity obtained with GNL in patients that died suggested the importance of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen as factors that are related to unwanted cardiovascular events and all-cause mortality and can possibly be seen as a prediction tool. Altered glycan structures composed of mannose residues are expected to affect the reactivity of mannosylated glycoproteins with mannose-binding lectin and possibly the entire cascade of events linked to this lectin. Since patients with ESRD are prone to cardiovascular complications and the formation of atherosclerotic plaques, one can hypothesize that fibrinogen with increasingly exposed mannose residues may contribute to the unwanted events.

Automated summary

As previously reported, fibrinogen fucosylation is a prognostic marker of peritoneal membrane function in ESRD patients. In this study, the ability of lectins and other biochemical parameters to predict mortality in these patients was evaluated. The results suggest that glucose concentration and the signal intensity obtained with GNL are potential predictors of mortality. Increased signal intensity with GNL in deceased patients indicates a potential role of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen in cardiovascular events and all-cause mortality.