4.6 Review

Mitochondria Transfer in Brain Injury and Disease

Journal

CELLS
Volume 11, Issue 22, Pages -

Publisher

MDPI
DOI: 10.3390/cells11223603

Keywords

mitochondria; brain; neuron; glia

Categories

Funding

  1. Universitat Basel Forschungsfonds [3PE1050]
  2. Novartis Foundation for Medical-Biological Research [22A007]
  3. Swiss National Science Foundation [31003A_179294, 31003A_149728]
  4. Novartis Foundation [18C143]
  5. Swiss National Science Foundation (SNF) [31003A_179294, 31003A_149728] Funding Source: Swiss National Science Foundation (SNF)

Ask authors/readers for more resources

Intercellular mitochondria transfer is a novel form of cell signalling that plays an important role in brain disorders and is considered a potential therapeutic strategy.
Intercellular mitochondria transfer is a novel form of cell signalling in which whole mitochondria are transferred between cells in order to enhance cellular functions or aid in the degradation of dysfunctional mitochondria. Recent studies have observed intercellular mitochondria transfer between glia and neurons in the brain, and mitochondrial transfer has emerged as a key neuroprotective mechanism in a range of neurological conditions. In particular, artificial mitochondria transfer has sparked widespread interest as a potential therapeutic strategy for brain disorders. In this review, we discuss the mechanisms and effects of intercellular mitochondria transfer in the brain. The role of mitochondrial transfer in neurological conditions, including neurodegenerative disease, brain injury, and neurodevelopmental disorders, is discussed as well as therapeutic strategies targeting mitochondria transfer in the brain.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available