4.6 Review

The Current Status of Photodynamic Therapy in Cancer Treatment

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Dual Tumor Microenvironment Remodeling by Glucose-Contained Radical Copolymer for MRI-Guided Photoimmunotherapy

Hongwei Cheng et al.

Summary: This study presents a novel material system using a glucose and TEMPO copolymer to encapsulate clinical therapeutics and a photosensitizer, achieving targeted therapy and multimodal imaging of tumors. The efficient delivery of the therapeutics leads to antitumor immune activation through photodynamic therapy and CD47 inhibition, reshaping the tumor microenvironment from immunosuppressive to immunoresponsive.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

An Energy-Storing DNA-Based Nanocomplex for Laser-Free Photodynamic Therapy

Huaixin Zhao et al.

Summary: A DNA nanocomplex is developed for photodynamic therapy (PDT) in breast cancer, enabling tumor-site glutathione-activated therapy without the need for external laser excitation. The nanocomplex integrates persistent-luminescence nanoparticles (PLNPs) as a self-illuminant to activate a photosensitizer and inhibit tumor growth through the production of cytotoxic oxygen.

ADVANCED MATERIALS (2022)

Review Medicine, Research & Experimental

Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Bin Ji et al.

Summary: Cancer immunotherapy has shown great progress in advanced-stage malignancies, but low response rates and immunosuppressive tumor microenvironments limit its effectiveness. Photodynamic therapy (PDT) can induce immunogenic cell death and enhance immune responses. Recent nanomedicine-based strategies have improved the efficiency of PDT and immunotherapy, and synergistic nanotherapeutics have been used to amplify immune responses. Challenges and future expectations in PDT-driven cancer immunotherapy are discussed.

THERANOSTICS (2022)

Article Biotechnology & Applied Microbiology

Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms

Yang Wang et al.

Summary: This study constructed a theranostic nanoplatform with homologous targeting ability and photoacoustic/fluorescence imaging ability, and demonstrated its potential application in osteosarcoma treatment through in vitro and in vivo experiments.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Chemistry, Multidisciplinary

Multifunctional DNAzyme-Anchored Metal-Organic Framework for Efficient Suppression of Tumor Metastasis

Yun Zhao et al.

Summary: This study developed a versatile theranostic agent to combat metastatic tumors. By delivering a specific DNAzyme, it effectively inhibits the invasion of cancer cells through gene silencing. The combined gene/chemodynamic therapy is achieved by self-supplied DNAzyme cofactors and efficient glutathione depletion. Additionally, the photothermal stimuli further promote the therapeutic strategy and accelerate the release of DNAzyme, resulting in effective tumor elimination and metastasis blockage.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Targeted Drug/Gene/Photodynamic Therapy via a Stimuli-Responsive Dendritic-Polymer-Based Nanococktail for Treatment of EGFR-TKI-Resistant Non-Small-Cell Lung Cancer

Jinxing Huang et al.

Summary: This study proposes a nanococktail therapeutic strategy for treating EGFR-TKI resistant NSCLC by targeted co-delivery of drugs and genes, along with photodynamic therapy. The results show that this nanococktail therapy effectively releases drugs and genes at the tumor site, demonstrating potent antitumor efficacy.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

An NIR-II Photothermally Triggered Oxygen Bomb for Hypoxic Tumor Programmed Cascade Therapy

Sidi Zhang et al.

Summary: The study presents a photothermally controlled oxygen release system for delivering oxygen to hypoxic tumors and customizes a programmed cascade therapy strategy to suppress tumor growth.

ADVANCED MATERIALS (2022)

Article Gastroenterology & Hepatology

Efficacy and safety of second photodynamic therapy for local failure after salvage photodynamic therapy for esophageal cancer

Hiroki Yamashita et al.

Summary: Second PDT showed good safety and acceptable efficacy in treating local failure after chemoradiotherapy for ESCC, indicating its potential as a treatment option for local recurrence after initial PDT.

DIGESTIVE ENDOSCOPY (2022)

Article Engineering, Biomedical

Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect

Haoran Wang et al.

Summary: Research has shown that using Chlorella in combination with photodynamic therapy (PDT) can enhance local tumor killing, improve the hypoxic and immunosuppressive microenvironment, increase the anti-tumor effect and immune response, and generate a stronger anti-tumor immune memory effect.

BIOACTIVE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Tumor Selective Metabolic Reprogramming as a Prospective PD-L1 Depression Strategy to Reactivate Immunotherapy

Yu Liu et al.

Summary: In this study, a new PD-L1 regulation strategy was developed by selectively down-regulating PD-L1 expression in tumors using mitochondria-targeted IR-LND@Alb nanoparticles. The anti-tumor efficacy of this strategy was found to be superior to conventional anti-PD-L1 monoclonal antibodies. Interestingly, IR-LND also showed potential as a novel photodynamic therapy (PDT) drug with self-oxygen and self-PD-L1 regulation capability.

ADVANCED MATERIALS (2022)

Review Oncology

Overview of Nanoparticle-Based Approaches for the Combination of Photodynamic Therapy (PDT) and Chemotherapy at the Preclinical Stage

Luca Menilli et al.

Summary: This review summarizes the recent literature reports (2017-2022) on nanoparticle-based formulations for anticancer therapy, focusing on photodynamic therapy (PDT), photosensitizers, and chemotherapeutics. It provides descriptions of different nanosystems and their abilities to address the limitations of PDT and chemotherapy. The therapeutic efficacy of these systems is analyzed in both in vitro and in vivo cancer models.

CANCERS (2022)

Review Oncology

The role of ROS in tumour development and progression

Eric C. Cheung et al.

Summary: Eukaryotic cells have complex systems to regulate reactive oxygen species (ROS), which are deregulated in cancer cells. ROS also modulate the tumor environment and affect stromal cells supporting metabolism, blood supply, and immune responses. The response to ROS is complex and depends on multiple factors, including ROS characteristics and tumor characteristics. Understanding the complexity of ROS in cancers is key to developing ROS-targeting therapies for cancer treatment.

NATURE REVIEWS CANCER (2022)

Article Chemistry, Multidisciplinary

A Self-Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety

Bin Yuan et al.

Summary: A supramolecular strategy was proposed to regulate the activity of photosensitizers for improved ROS generation efficiency and accelerated self-degradation ability during PDT treatment, leading to reduced dark toxicity and potential side effects.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Pharmacology & Pharmacy

Photodynamic and antibiotic therapy in combination against bacterial infections: efficacy, determinants, mechanisms, and future perspectives

Yanfang Feng et al.

Summary: Combination therapy of PDT and antibiotics shows promising potential in overcoming the limitations of antibiotic treatment and PDT, exerting increased disinfection efficacy on multidrug-resistant bacterial pathogens.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Chemistry, Multidisciplinary

Bioorthogonal Coordination Polymer Nanoparticles with Aggregation-Induced Emission for Deep Tumor-Penetrating Radio- and Radiodynamic Therapy

Jingjing Liu et al.

Summary: Radiodynamic therapy (RDT) is a promising therapeutic approach for cancer treatment that combines ionizing irradiation and localized photodynamic therapy (PDT). Hf-AIE coordination polymer nanoparticles (CPNs) show strong RT and RDT effects under X-ray irradiation. Bioorthogonal click chemistry enhances tumor accumulation and retention of CPNs, leading to significant killing of cancer cells without noticeable biotoxicity.

ADVANCED MATERIALS (2021)

Article Engineering, Biomedical

Multistage targeted Photoactive neutrophil for enhancing synergistic photo-chemotherapy

Yurui Xu et al.

Summary: Cell-based drug delivery system has great potential in anticancer treatment, with the bioengineered Photoactive neutrophil (PAN) showing enhanced efficacy in mitochondria-specific phototherapy, suggesting a promising approach for cancer therapy.

BIOMATERIALS (2021)

Review Chemistry, Multidisciplinary

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Thanh Chung Pham et al.

Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.

CHEMICAL REVIEWS (2021)

Article Chemistry, Multidisciplinary

Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer

Fang Sun et al.

Summary: The study presents a novel strategy to enhance photoimmunotherapy of pancreatic cancer by provoking T cells activation and overcoming adaptive immune resistance.

ADVANCED SCIENCE (2021)

Article Chemistry, Multidisciplinary

Ultrathin 2D Copper(I) 1,2,4-Triazolate Coordination Polymer Nanosheets for Efficient and Selective Gene Silencing and Photodynamic Therapy

Si-Yang Liu et al.

Summary: A multifunctional ultrathin 2D nanosheet was synthesized, serving as a dual-action platform for gene silencing and photodynamic therapy in cancer treatment. These nanosheets demonstrated targeted gene silencing in breast cancer cells and high antitumor efficacy under photoirradiation.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Cancer-Cell-Activated in situ Synthesis of Mitochondria-Targeting AIE Photosensitizer for Precise Photodynamic Therapy

Yuanbo Wang et al.

Summary: This study presents a cancer-cell-activated photosensitizer synthesis strategy to selectively synthesize efficient PS with mitochondria-targeting capability for potent cancer-cell-specific ablation under light irradiation, ensuring high specificity and safety for post-treatment.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Trojan Horse-Like Nano-AIE Aggregates Based on Homologous Targeting Strategy and Their Photodynamic Therapy in Anticancer Application

Yin Li et al.

Summary: The study synthesized two near-infrared emitters with aggregation-induced ROS generation characteristics and found that they exhibit excellent LD-specific targeting ability, with PTI demonstrating more effective red emission and intersystem crossing compared to PI. Additionally, the detailed therapeutic mechanism of PDT in LDs specificity was investigated, confirming the oxidation of polyunsaturated fatty acids in LDs to form toxic lipid peroxides and causing cellular ferroptosis.

ADVANCED SCIENCE (2021)

Review Chemistry, Multidisciplinary

Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy

Muhammad Rizwan Younis et al.

Summary: Inorganic nanomaterials with intrinsic singlet oxygen generation capability are emerging as nano-photosensitizers for photodynamic therapy, exhibiting high quantum yield. Various materials such as metal-based, metal oxide-based, metal sulfide-based, carbon-based, phosphorus-based, and others have been utilized for material design to achieve phototherapeutic effects, with future research facing numerous challenges.

ADVANCED SCIENCE (2021)

Review Oncology

Could Photodynamic Therapy Be a Promising Therapeutic Modality in Hepatocellular Carcinoma Patients? A Critical Review of Experimental and Clinical Studies

Abhishek Kumar et al.

Summary: Hepatocellular Carcinoma (HCC) is a major cause of cancer-related mortality worldwide, with limited treatment options. This review explores the mechanism and benefits of Photodynamic Therapy (PDT) as an anti-cancer therapy, focusing on its application in HCC treatment. The review also discusses the immune response generated by PDT and its potential role in HCC treatment, proposing a combination approach with existing therapies.

CANCERS (2021)

Article Multidisciplinary Sciences

C(sp3)-H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling

Aristidis Vasilopoulos et al.

Summary: The research presents a synthetic method that allows for direct methylation of C(sp(3))-H bonds in drug-like molecules and pharmaceutical building blocks, leading to changes in potency, selectivity, and metabolic stability.

SCIENCE (2021)

Article Chemistry, Multidisciplinary

Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep-Seated Tumors

Hui Bian et al.

Summary: In this study, five novel NIR-II dyes were successfully developed with intense absorption ranging from 890 to 1206 nm, strong singlet oxygen generation capability, and fluorescence imaging ability triggered by a single NIR-II light. Among them, BH 1024 showed the best performance in singlet oxygen generation, moderate photothermal heating, and considerable fluorescence under 1064 nm laser irradiation. Encapsulating BH 1024 into folate-functionalized polymer demonstrated a synergetic PDT/PTT effect in vitro and in vivo, eventually achieving solid tumors elimination under NIR-II fluorescence guide. This is the first attempt to explore and design small molecular dyes for NIR-II PDT or NIR-II PDT/PTT.

SMALL (2021)

Article Chemistry, Multidisciplinary

Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of Small-Interfering RNA and Antisense Oligonucleotide

Lei Chen et al.

Summary: This study developed a PSNA for carrier-free and NIR photocontrolled self-delivery of siRNA and ASO, which could selectively release therapeutic agents in tumor cells under NIR light irradiation. PSNA showed promising potential for cancer therapy by combining gene therapy and photodynamic therapy.

ACS NANO (2021)

Article Cell Biology

Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

Marica Rosaria Ippolito et al.

Summary: Mitotic errors causing aneuploidy can lead to genome instability, affecting gene copy number and influencing cancer cells' resistance to chemotherapy. This may explain why some chemotherapy treatments fail.

DEVELOPMENTAL CELL (2021)

Review Chemistry, Multidisciplinary

Type I Photosensitizers Revitalizing Photodynamic Oncotherapy

Dapeng Chen et al.

Summary: Photodynamic therapy (PDT) has great potential for tumor treatment, with type I PDT showing superiority over type II PDT in treating hypoxic tumors. Recent research focuses on developing highly effective type I photosensitizers and addressing key challenges in clinical translations of these photosensitizers.

SMALL (2021)

Article Biochemistry & Molecular Biology

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Sufang Shui et al.

Summary: The study shows that photodynamic therapy (PDT) can induce lipid peroxidation and cell death similar to ferroptosis, termed as liperoptosis, which is independent of lipoxygenase and ACSL4. Using a clinically approved photosensitizer, PDT effectively inhibits tumor growth through triggering lipid peroxidation and cell death. These findings suggest the potential value of using PDT to induce lipid peroxidation and ferroptosis-like cell death in vivo for cancer treatment and exploring the immunological effects of PDT.

REDOX BIOLOGY (2021)

Review Medicine, Research & Experimental

Recent progress in nanomedicine for enhanced cancer chemotherapy

Guoqing Wei et al.

Summary: Nanomedicine has shown significant progress in improving cancer chemotherapy, including drug enrichment and tissue penetration, subcellular organelle-targeted chemotherapy, and reversal of multidrug resistance. The advantages of combination therapy in cancer treatment are emphasized.

THERANOSTICS (2021)

Article Chemistry, Physical

Engineering a photosensitizer nanoplatform for amplified photodynamic immunotherapy via tumor microenvironment modulation

Yaxin Zhou et al.

Summary: The engineered photosensitizer nanoplatform integrates chlorin e6, axitinib, and dextro-1-methyl tryptophan to enhance the efficacy of photodynamic immunotherapy by modulating the tumor microenvironment. This approach improves PDT and immunotherapy effects by normalizing tumor blood vessels and inhibiting IDO activity.

NANOSCALE HORIZONS (2021)

Review Nanoscience & Nanotechnology

Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers

Jie Zhao et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020)

Article Chemistry, Multidisciplinary

Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging

Zhe Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Programming DNA Nanoassembly for Enhanced Photodynamic Therapy

Min Pan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Evaluation of a Bispidine-Based Chelator for Gallium-68 and of the Porphyrin Conjugate as PET/PDT Theranostic Agent

Thomas W. Price et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

Review Biochemistry & Molecular Biology

Hadrontherapy Interactions in Molecular and Cellular Biology

Juliette Thariat et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Editorial Material Oncology

Proton-Beam Therapy: At the Heart of Cardiac Dose-Sparing in Mediastinal Radiotherapy for Thymic Carcinoma

Andrew R. Barsky et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

Article Chemistry, Multidisciplinary

Fluorination Enhances NIR-II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

Ye Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Penetrable Nanoplatform for Cold Tumor Immune Microenvironment Reeducation

Qinjun Chen et al.

ADVANCED SCIENCE (2020)

Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Multidisciplinary Sciences

Urine metabolomics based prediction model approach for radiation exposure

Ritu Tyagi et al.

SCIENTIFIC REPORTS (2020)

Article Chemistry, Medicinal

Hydroxy-corrole and its gallium(III) complex as new photosensitizer for photodynamic therapy against breast carcinoma

Yan-Mei Sun et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor

Ballav M. Borah et al.

SCIENTIFIC REPORTS (2020)

Review Chemistry, Multidisciplinary

Multifunctional sonosensitizers in sonodynamic cancer therapy

Subin Son et al.

CHEMICAL SOCIETY REVIEWS (2020)

Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Gastroenterology & Hepatology

Role of photodynamic therapy in the treatment of esophageal cancer

Hao Wu et al.

DIGESTIVE ENDOSCOPY (2019)

Article Nanoscience & Nanotechnology

Light-Activatable Prodrug and AIEgen Copolymer Nanoparticle for Dual-Drug Monitoring and Combination Therapy

Peng Wu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Article Chemistry, Multidisciplinary

An Emerging Molecular Design Approach to Heavy-Atom-Free Photosensitizers for Enhanced Photodynamic Therapy under Hypoxia

Van-Nghia Nguyen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Urology & Nephrology

Photodynamic Therapy in the Treatment of Bladder Cancer: Past Challenges and Current Innovations

Reema Railkar et al.

EUROPEAN UROLOGY FOCUS (2018)

Review Medicine, General & Internal

Recent Developments in Radiotherapy

Deborah E. Citrin

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Chemistry, Multidisciplinary

Controllable Photodynamic Therapy Implemented by Regulating Singlet Oxygen Efficiency

Wenting Wu et al.

ADVANCED SCIENCE (2017)

Review Nanoscience & Nanotechnology

Advances in antimicrobial photodynamic inactivation at the nanoscale

Nasim Kashef et al.

NANOPHOTONICS (2017)

Article Nanoscience & Nanotechnology

Relighting Photosensitizers by Synergistic Integration of Albumin and Perfluorocarbon for Enhanced Photodynamic Therapy

Hao Ren et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Oncology

PDT: What's Past Is Prologue

Keith A. Cengel et al.

CANCER RESEARCH (2016)

Review Chemistry, Multidisciplinary

Nanoparticles in Photodynamic Therapy

Sasidharan Swarnalatha Lucky et al.

CHEMICAL REVIEWS (2015)

Article Materials Science, Biomaterials

Dual pH-responsive mesoporous silica nanoparticles for efficient combination of chemotherapy and photodynamic therapy

Xuemei Yao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

Review Pharmacology & Pharmacy

Free radicals and antioxidants - quo vadis?

Barry Halliwell

TRENDS IN PHARMACOLOGICAL SCIENCES (2011)

Article Oncology

Cell Death Pathways in Photodynamic Therapy of Cancer

Pawel Mroz et al.

Cancers (2011)

Review Oncology

Photodynamic therapy in oncology

Martijn Triesscheijn et al.

ONCOLOGIST (2006)

Article Dermatology

Photodynamic therapy in dermatology - an update

P Babilas et al.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2005)