4.6 Article

Phenotypic Characterization of Circulating Tumor Cells Isolated from Non-Small and Small Cell Lung Cancer Patients

Related references

Note: Only part of the references are listed.
Article Developmental Biology

Epithelial-to-mesenchymal transition of tumor cells: cancer progression and metastasis

Vasileios Vardas et al.

Summary: Detection and characterization of CTCs with an EMT phenotype in breast cancer patients was evaluated using the CellSearch system. Vimentin expression was studied and the presence of CK-VIM+CD45- phenotype was observed in both early and metastatic breast cancer patients, suggesting its potential importance in identifying undetectable tumor cells and providing additional information regarding metastasis.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2022)

Article Health Care Sciences & Services

Detyrosinated α-Tubulin, Vimentin and PD-L1 in Circulating Tumor Cells (CTCs) Isolated from Non-Small Cell Lung Cancer (NSCLC) Patients

Spyridoula D. Katsarou et al.

Summary: This study evaluated the expression levels of cytoskeletal proteins in CTCs from NSCLC patients and found that high expression of GLU and VIM is associated with poor prognosis. PD-L1 is also related to patients' outcomes. Furthermore, the expression levels of TUB in CTCs inversely influence patients' overall survival.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Oncology

The clinicopathological and prognostic value of CXCR4 expression in patients with lung cancer: a meta-analysis

Liping Qiu et al.

Summary: High expression of CXCR4 in lung cancer is associated with poor overall survival and disease-free survival. It is significantly correlated with poor overall survival in non-small cell lung cancer patients and patients showing CXCR4 expression in the cytoplasm and the membrane.

BMC CANCER (2022)

Review Oncology

Liquid biopsies: Potential and challenges

Isabel Heidrich et al.

Summary: Liquid biopsy (LB) presents broad opportunities in oncology, allowing early detection, risk assessment, and monitoring of cancer therapies with comprehensive and real-time information. Circulating tumor cells (CTCs) and circulating tumor-derived DNA (ctDNA) are key LB markers for breast, prostate, lung, and colorectal cancer. Current implementation of LB in clinical practice is hindered by methodological and biological limitations.

INTERNATIONAL JOURNAL OF CANCER (2021)

Article Cell Biology

CXCR4 uses STAT3-mediated slug expression to maintain radioresistance of non-small cell lung cancer cells: emerges as a potential prognostic biomarker for lung cancer

Jeong-Yub Kim et al.

Summary: The study uncovered that the expression of CXCR4 confers resistance to ionizing radiation in nonsmall cell lung cancer cells by modulating the STAT3 signaling pathway. Therefore, the CXCR4/STAT3/Slug axis is crucial for the IR resistance of lung cancer cells and could be a therapeutic target.

CELL DEATH & DISEASE (2021)

Article Multidisciplinary Sciences

Gene expression in circulating tumor cells reveals a dynamic role of EMT and PD-L1 during osimertinib treatment in NSCLC patients

Aliki Ntzifa et al.

Summary: Liquid biopsy was used to investigate gene expression changes in CTC-enriched fractions of EGFR-mutant NSCLC patients treated with osimertinib. The study found correlations between epithelial and stem cell profile, mesenchymal/EMT and stem cell profile at progression of disease, as well as a strong positive correlation of VIM expression with PIM-1 expression at baseline and increased PD-L1 expression levels at progression of disease.

SCIENTIFIC REPORTS (2021)

Article Health Care Sciences & Services

Cancer Stem Cell-Like Circulating Tumor Cells Are Prognostic in Non-Small Cell Lung Cancer

Eva Obermayr et al.

Summary: This study highlighted the importance of molecular characterization of circulating tumor cells (CTCs) in NSCLC patients. The analysis found that cancer stem cell-related transcripts were significantly associated with overall survival at both primary diagnosis and disease progression.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Review Oncology

Clinical Relevance of Mesenchymal- and Stem-Associated Phenotypes in Circulating Tumor Cells Isolated from Lung Cancer Patients

Evangelia Pantazaka et al.

Summary: Lung cancer is the most common malignancy worldwide, characterized by late diagnosis and poor survival rates. Circulating tumor cells (CTCs) play a crucial role in lung cancer progression, acquiring EMT and CSC features to aid in survival and metastasis.

CANCERS (2021)

Article Medical Laboratory Technology

Programmed Cell Death Ligand 1-Expressing Circulating Tumor Cells: A New Prognostic Biomarker in Non-Small Cell Lung Cancer

Lea Sinoquet et al.

Summary: The presence of PD-L1(+) CTCs is associated with poor prognosis in patients with advanced NSCLC, showing low concordance with PD-L1 expression in tumor tissue, and further studies with larger samples are needed for confirmation.

CLINICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB

Sasithorn Wanna-udom et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Oncology

Mechanisms and Future of Non-Small Cell Lung Cancer Metastasis

Tianhao Zhu et al.

FRONTIERS IN ONCOLOGY (2020)

Review Medicine, Research & Experimental

Circulating Tumor Cells in Diagnosis and Treatment of Lung Cancer

Vilem Maly et al.

IN VIVO (2019)

Article Biochemistry & Molecular Biology

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion

Anders Sundqvist et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Biochemistry & Molecular Biology

The good and bad faces of the CXCR4 chemokine receptor

Joaquin Teixido et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Article Oncology

Evaluation of PD-L1/PD-1 on circulating tumor cells in patients with advanced non-small cell lung cancer

Galatea Kallergi et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2018)

Article Oncology

CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer

Zhenbo Tu et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

Transforming growth factor-β1 regulation of ATF-3, c-Jun and JunB proteins for activation of matrix metalloproteinase-13 gene in human breast cancer cells

M. Gokulnath et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Review Oncology

Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer

Marianna Gallo et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2017)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Article Cell Biology

Evaluation of Isolation Methods for Circulating Tumor Cells (CTCs)

Galatea Kallergi et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

Review Immunology

CXCR4 signaling in health and disease

Tommaso Pozzobon et al.

IMMUNOLOGY LETTERS (2016)

Article Oncology

JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma

Hiroshi Hyakusoku et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

XCR1 promotes cell growth and migration and is correlated with bone metastasis in non-small cell lung cancer

Ting Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Review Medical Laboratory Technology

Circulating tumor cells as promising novel biomarkers in solid cancers

Evi S. Lianidou et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2014)

Article Biochemistry & Molecular Biology

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer

Cassandra L. Hodgkinson et al.

NATURE MEDICINE (2014)

Article Pathology

Circulating Tumor Cells as a Window on Metastasis Biology in Lung Cancer

Jian-Mei Hou et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Oncology

Circulating tumor cells in patients with breast cancer dormancy

SD Meng et al.

CLINICAL CANCER RESEARCH (2004)