4.6 Article

Transcriptional Profiling Reveals Mesenchymal Subtypes of Small Cell Lung Cancer with Activation of the Epithelial-to-Mesenchymal Transition and Worse Clinical Outcomes

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Analysing high-throughput sequencing data in Python with HTSeq 2.0

Givanna H. Putri et al.

Summary: HTSeq 2.0 provides an expanded application programming interface, including a new representation for sparse genomic data, enhancements for htseq-count to accommodate single-cell omics, a new script for data using cell and molecular barcodes, improved documentation, testing and deployment, bug fixes, and Python 3 support.

BIOINFORMATICS (2022)

Article Oncology

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

Carl M. Gay et al.

Summary: Despite the heterogeneity of small cell lung cancer (SCLC), four subtypes have been identified based on tumor expression data, each showing different responses to treatment. SCLC-I subtype benefits the most from immunotherapy, while other subtypes have vulnerabilities to different inhibitors. Matching tumor subtype to therapy and manipulating subtype switching during treatment may enhance response depth and duration for SCLC patients.

CANCER CELL (2021)

Article Medicine, General & Internal

Small-cell lung cancer

Charles M. Rudin et al.

Summary: Small-cell lung cancer is a type of lung cancer characterized by high proliferative rate, early metastasis, and poor prognosis, strongly associated with tobacco carcinogens. Most patients are diagnosed with metastatic disease, with only a small fraction having potentially curative earlier-stage disease. Genomic profiling reveals extensive chromosomal rearrangements and high mutation burden in SCLC, often involving inactivation of TP53 and RB1 tumor suppressor genes.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Oncology

YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell-Inflamed Phenotype

Taofeek K. Owonikoko et al.

Summary: This study identified four subtypes of SCLC using RNA sequencing and immunohistochemistry, with the SCLC-Y subtype associated with an inflamed phenotype and favorable prognosis. Upregulation of interferon-gamma response genes was observed in long-term survivors, with higher expression in patients of the SCLC-Y subtype.

JOURNAL OF THORACIC ONCOLOGY (2021)

Article Oncology

The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response

Guangyu Wang et al.

Summary: This study reveals the complex interplay between EMT and immune evasion, as well as their significant impact on tumor behavior and clinical outcomes. Quantitative analysis identified factors associated with the balance between EMT and immune evasion, such as cellular composition, mutation burden, chromosomal stability, and oncogenic gene alterations. The proposed EMT-CYT Index (ECI) scoring model emerged as a superior predictor of prognosis and immunotherapy response across different malignancies.

NPJ PRECISION ONCOLOGY (2021)

Article Multidisciplinary Sciences

Next-generation characterization of the Cancer Cell Line Encyclopedia

Mahmoud Ghandi et al.

NATURE (2019)

Article Biotechnology & Applied Microbiology

Determining cell type abundance and expression from bulk tissues with digital cytometry

Aaron M. Newman et al.

NATURE BIOTECHNOLOGY (2019)

Article Genetics & Heredity

Molecular landmarks of tumor hypoxia across cancer types

Vinayak Bhandari et al.

NATURE GENETICS (2019)

Article Cell Biology

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

Yu-Han Huang et al.

GENES & DEVELOPMENT (2018)

Article Medicine, Research & Experimental

IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade

Mark Ayers et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Oncology

Unravelling the biology of SCLC: implications for therapy

Joshua K. Sabari et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Multidisciplinary Sciences

Fluid shear stress activates YAP1 to promote cancer cell motility

Hyun Jung Lee et al.

NATURE COMMUNICATIONS (2017)

Review Oncology

Small-cell lung cancer: what we know, what we need to know and the path forward

Adi F. Gazdar et al.

NATURE REVIEWS CANCER (2017)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Article Biochemistry & Molecular Biology

Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network

Jiajia Yang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

Comprehensive genomic profiles of small cell lung cancer

Julie George et al.

NATURE (2015)

Article Genetics & Heredity

Stromal contribution to the colorectal cancer transcriptome

Claudio Isella et al.

NATURE GENETICS (2015)

Article Biochemistry & Molecular Biology

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

Razvan Cristescu et al.

NATURE MEDICINE (2015)

Article Oncology

The emerging roles of YAP and TAZ in cancer

Toshiro Moroishi et al.

NATURE REVIEWS CANCER (2015)

Review Developmental Biology

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

Xaralabos Varelas

DEVELOPMENT (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Oncology

Selective Tropism of Seneca Valley Virus for Variant Subtype Small Cell Lung Cancer

J. T. Poirier et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Multidisciplinary Sciences

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM

Jihan K. Osborne et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Inferring tumour purity and stromal and immune cell admixture from expression data

Kosuke Yoshihara et al.

NATURE COMMUNICATIONS (2013)

Article Multidisciplinary Sciences

Integrated genomic analyses of ovarian carcinoma

D. Bell et al.

NATURE (2011)

Review Oncology

Targeting hypoxia in cancer therapy

William R. Wilson et al.

NATURE REVIEWS CANCER (2011)

Article Biochemical Research Methods

Caleydo: connecting pathways and gene expression

Marc Streit et al.

BIOINFORMATICS (2009)

Article Biochemical Research Methods

ARACNE: An algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context

AA Margolin et al.

BMC BIOINFORMATICS (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Metagenes and molecular pattern discovery using matrix factorization

JP Brunet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Diagnosis of multiple cancer types by shrunken centroids of gene expression

R Tibshirani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Integrin β1 signaling is necessary for transforming growth factor-β activation of p38MAPK and epithelial plasticity

NA Bhowmick et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)