4.7 Review

Talimogene Laherparepvec (T-VEC): A Review of the Recent Advances in Cancer Therapy

Related references

Note: Only part of the references are listed.
Review Oncology

Immunotherapy for Nonmelanoma Skin Cancer: Facts and Hopes

Sophia Z. Shalhout et al.

Summary: Nonmelanoma skin cancer is the most common malignancy in humans, with keratinocyte carcinomas being the most frequent subtype. The incidence of this cancer is rising due to aging population and increased ultraviolet radiation exposure. Immunotherapy has emerged as a new treatment option for advanced cases not amenable to surgery and/or radiation.

CLINICAL CANCER RESEARCH (2022)

Review Cell Biology

Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons

Adel Naimi et al.

Summary: The discovery of immune checkpoint proteins led to the development of immune checkpoint inhibitors (ICIs), a promising approach in tumor immunotherapy. However, resistance and treatment-related toxicities remain challenges in the clinical application of ICIs.

CELL COMMUNICATION AND SIGNALING (2022)

Article Oncology

The evolutionary legacy of immune checkpoint inhibitors

Itishree Kaushik et al.

Summary: Immune checkpoint inhibitors have revolutionized cancer immunotherapy, but their efficacy is limited to specific tumor types and is often accompanied by resistance and immune-related adverse effects.

SEMINARS IN CANCER BIOLOGY (2022)

Article Dermatology

Talimogene laherparepvec resulting in near-complete response in a patient with treatment-refractory Merkel cell carcinoma

Michael A. Cilento et al.

Summary: Merkel cell carcinoma (MCC) is a rare and aggressive tumor that can grow rapidly and metastasize early. Treatment options include surgery, radiotherapy, chemotherapy, radionuclide therapy, immunotherapy, and intralesional therapy. This case report highlights the exceptional response of a patient who had exhausted all available treatments to intralesional injection of TVEC.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2022)

Review Oncology

Advances in Cutaneous Squamous Cell Carcinoma Management

Carrick Burns et al.

Summary: Cutaneous squamous cell carcinoma (cSCC) is a prevalent and morbid cancer, and recent developments in risk stratification and treatment options, such as immune checkpoint inhibitors, have improved outcomes for patients with locally advanced and metastatic disease. Ongoing clinical trials continue to advance the field and offer hope for better management of cSCC in the future.

CANCERS (2022)

Article Oncology

A Phase I Trial of Talimogene Laherparepvec in Combination with Neoadjuvant Chemotherapy for the Treatment of Nonmetastatic Triple-Negative Breast Cancer

Hatem Soliman et al.

Summary: The study combined TVEC and NAC for TNBC treatment, with postoperative evaluation using RCB. It found that adding TVEC at approved dose was feasible and resulted in a complete response rate of 55%. Most patients tolerated the treatment well with manageable toxicities.

CLINICAL CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB-IVM1a melanoma: a randomized, open-label, phase 2 trial

R. Dummer et al.

Summary: The study found that intralesional injection of an oncolytic virus prior to surgery is clinically beneficial for patients with locally advanced, resectable melanoma, leading to improved recurrence-free survival.

NATURE MEDICINE (2021)

Article Cell Biology

Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1

Riikka Havunen et al.

Summary: The oncolytic adenovirus TILT-123 shows safety in preclinical studies and has the potential to be used in combination with immune checkpoint inhibitors for cancer treatment. It exerts its therapeutic effect by activating T cells in the tumor microenvironment.

CELLS (2021)

Article Multidisciplinary Sciences

A phase II study of talimogene laherparepvec for patients with inoperable locoregional recurrence of breast cancer

Megumi Kai et al.

Summary: In this study, intratumoral administration of T-VEC as monotherapy for inoperable locoregional recurrence of breast cancer did not achieve complete or partial response in most patients. Most patients withdrew prematurely due to disease progression, with only two patients experiencing clinically stable disease after 8 cycles. The most common adverse event was injection site reaction. Further studies are needed to explore the potential benefits of combining intratumoral T-VEC with systemic therapy.

SCIENTIFIC REPORTS (2021)

Article Oncology

Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB-IVM1c melanoma

Josep Malvehy et al.

Summary: This study demonstrates that T-VEC induces systemic immune activity and modifies the tumor microenvironment, potentially enhancing the efficacy of combination immunotherapy with other agents.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Biochemistry & Molecular Biology

Oncolytic Virotherapy for Cancer: Clinical Experience

Shyambabu Chaurasiya et al.

Summary: Oncolytic viruses are a new class of therapeutics that have shown promise in clinical trials, although their anti-tumor efficacy as monotherapy is modest. Most oncolytic viruses are well tolerated, even in immune-suppressed patients, at the currently defined highest feasible doses. Enhancing the potency of oncolytic viruses is necessary for more viruses to be used effectively in clinical settings, thus they are being studied in combination with other therapies for higher therapeutic benefits.

BIOMEDICINES (2021)

Review Medicine, General & Internal

Recent Advances in the Treatment of Melanoma

Brendan D. Curti et al.

Summary: Improvements in management have led to increased survival rates for melanoma, with advances such as sentinel-node sampling and targeted therapy reducing morbidity and enhancing treatment outcomes for advanced disease.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Oncology

Immunotherapy for Merkel cell carcinoma: a turning point in patient care

Isaac S. Chan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Review Oncology

Combining talimogene laherparepvec with immunotherapies in melanoma and other solid tumors

Reinhard Dummer et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

Article Medicine, General & Internal

Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy

A. M. M. Eggermont et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Biochemistry & Molecular Biology

Genomic Classification of Cutaneous Melanoma

Rehan Akbani et al.

Article Oncology

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

Robert H. I. Andtbacka et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Oncology

Phase 2 Study of Intralesional PV-10 in Refractory Metastatic Melanoma

John F. Thompson et al.

ANNALS OF SURGICAL ONCOLOGY (2015)

Review Oncology

The emerging therapeutic potential of the oncolytic immunotherapeutic Pexa-Vec (JX-594)

Caroline J. Breitbach et al.

ONCOLYTIC VIROTHERAPY (2015)

Review Oncology

Oncolytic viruses in cancer therapy

Markus J. V. Vaha-Koskela et al.

CANCER LETTERS (2007)

Review Oncology

Oncolytic biotherapy: a novel therapeutic platform

LK Hawkins et al.

LANCET ONCOLOGY (2002)