Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/jcm11247504
Keywords
fibrinogen; placental abruption; fetal acidemia
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This study aimed to identify factors predicting the probability of serious fetal acidemia in placental abruption. The study found that abnormal fetal heart rate patterns, uterine spasms, and low maternal fibrinogen concentration are significantly associated with the occurrence of serious fetal acidemia.
This study aimed to identify factors predicting the probability of serious fetal acidemia at delivery in placental abruption. We identified 5769 women who delivered at >22 weeks' gestation at two institutions in a tertiary referral unit specializing in neonatal infant care between January 2007 and December 2011. Ninety-one abruption cases were identified based on clinical and histological diagnoses. Serious fetal acidemia was defined as a pH < 7.0 in the umbilical arterial blood at delivery. Using a linear discriminant function, we calculated the score to determine the probability of serious fetal acidemia. Serious fetal acidemia was observed in 34 patients (37.4%). A logistic regression model showed that abnormal fetal heart rate patterns (bradycardia and late decelerations), uterine spasm, and maternal plasma concentration of fibrinogen less than 288 ng/dL were significantly associated with the occurrence of serious fetal acidemia. We suggest that the implementation of maternal fibrinogen in patients with placental abruption is a prognostic factor for serious fetal acidemia at delivery.
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