Coxiella burnetii and Bartonella Endocarditis Diagnosed by Metagenomic Next-Generation Sequencing

Article Pediatrics

Risk Factors for Severe COVID-19 in Children

Rebecca C. Woodruff et al.

Summary: This study describes population-based rates and risk factors for pediatric severe COVID-19. The study found that children under the age of 2 with chronic lung disease, neurologic disorders, cardiovascular disease, prematurity, and airway abnormality, as well as children aged 2 to 17 depending on a feeding tube, with diabetes mellitus, and with obesity, are more susceptible to severe COVID-19. The results of this study are important for identifying high-risk children and implementing prevention efforts, including vaccination.

PEDIATRICS (2022)

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Review Microbiology

Staphylococcus aureus Internalization in Osteoblast Cells: Mechanisms, Interactions and Biochemical Processes. What Did We Learn from Experimental Models?

Stefano Stracquadanio et al.

Summary: Bacterial internalization is a strategy used by non-intracellular microorganisms to evade the host immune system and survive in the human body. Staphylococcus aureus interacts with and infects osteoblasts, leading to osteomyelitis and infections. The MG-63 osteoblastic cell line is the best traditional model for studying these interactions, although more representative 3D models have also been investigated.

PATHOGENS (2021)

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Article Microbiology

Laboratory Diagnosis of 37 Cases of Bartonella Endocarditis Based on Enzyme Immunoassay and Real-Time PCR

Lev Shapira et al.

Summary: Bartonella spp., mainly B. quintana and B. henselae, are common causes of culture-negative endocarditis and their diagnosis relies on serology and PCR. A new enzyme immunoassay and multiplex real-time PCR, which identified additional Bartonella species, showed promise in diagnosing Bartonella endocarditis. However, caution is necessary due to cross-reactivity between B. henselae and B. quintana, as well as with other bacterial infections.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology