4.7 Review

Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) for Immunomodulation in COVID-19 Related Acute Respiratory Distress Syndrome (ARDS)

Related references

Note: Only part of the references are listed.
Article Immunology

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Matteo Stravalaci et al.

Summary: This study demonstrates that selected human humoral fluid-phase pattern recognition molecules can interact with SARS-CoV-2 in COVID-19, including PTX3 and MBL, exerting antiviral activity and being associated with disease severity. These findings have important implications for resistance and pathogenesis of COVID-19.

NATURE IMMUNOLOGY (2022)

Review Biochemistry & Molecular Biology

Immune response in COVID-19: what is next?

Qing Li et al.

Summary: This article reviews the unprecedented impact of COVID-19 on our daily lives and quality of life over a period of more than two years, focusing on the changes in immune response, virus mutations, vaccines, and treatment strategies. The authors predict that with the use of existing and emerging technologies, we will be able to control the COVID-19 pandemic.

CELL DEATH AND DIFFERENTIATION (2022)

Review Medicine, Research & Experimental

The effect of polyunsaturated fatty acids on the severity and mortality of COVID patients: A systematic review

Afrooz Mazidimoradi et al.

Summary: This study investigates the effect of polyunsaturated fatty acids on the prognosis of Covid-19. The findings suggest that Ω-3 supplements can reduce the risk of Covid-19, but elevated levels of fatty acids in the lungs and cytokine storm may be the main reasons for mortality in severe cases.

LIFE SCIENCES (2022)

Article Biochemistry & Molecular Biology

Inhalation of nebulized omega-3 fatty acids mitigate LPS-induced acute lung inflammation in rats: Implications for treatment of COPD and COVID-19

Chandrashekhar Kocherlakota et al.

Summary: This study aimed to investigate if O3FA administered by inhalation of a nebulized formulation can alleviate LPS-induced acute lung inflammation. The results showed that O3FA effectively reduced the severity of lung inflammation and attenuated the inflammatory response of cytokines.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2022)

Article Medicine, General & Internal

How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19?

Paloma Moreno-Nunez et al.

Summary: Vaccination against COVID-19 significantly reduces the risk of death and shortens hospital stay for hospitalized patients.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Immunology

The state of complement in COVID-19

Behdad Afzali et al.

Summary: Hyperactivation of the complement system is implicated in the pathology of COVID-19, with potential therapeutic benefits through complement inhibition. Latest research progress suggests targeting complement components for treatment may be beneficial in mitigating excessive inflammation and thrombosis in severe COVID-19 cases.

NATURE REVIEWS IMMUNOLOGY (2022)

Review Pharmacology & Pharmacy

Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

Ahmed M. Darwesh et al.

Summary: The global COVID-19 pandemic caused by SARS-CoV-2 has led to millions of confirmed cases worldwide. The exaggerated immune response, hypercoagulation, and oxidative stress triggered by viral infection significantly impact the cardiovascular health of COVID-19 patients. n-3 polyunsaturated fatty acids (n-3 PUFAs) may serve as potential adjuvant therapies for COVID-19 management, with demonstrated beneficial effects on controlling inflammation, reducing oxidative stress, and mitigating coagulopathy.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Biochemistry & Molecular Biology

Specialized proresolving mediators in infection and lung injury

Shayna Sandhaus et al.

Summary: Specialized proresolving mediators (SPMs) are endogenous lipid metabolites that promote the resolution of inflammation. While not yet studied in the context of the novel Coronavirus, SPMs have shown potential in combating infections and inflammatory lung conditions.

BIOFACTORS (2021)

Review Biochemistry & Molecular Biology

Adaptive immunity to SARS-CoV-2 and COVID-19

Alessandro Sette et al.

Summary: The adaptive immune system, consisting of B cells, CD4(+) T cells, and CD8(+) T cells, plays varying roles in different viral infections and vaccines. Studies are showing that CD4(+) T cells, CD8(+) T cells, and neutralizing antibodies all play a part in controlling SARS-CoV-2 in COVID-19 cases, emphasizing the importance of understanding adaptive immunity in combating the disease.
Article Biochemistry & Molecular Biology

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Daniel Wendisch et al.

Summary: Analysis of pulmonary immune responses and lung pathology in patients with COVID-19 ARDS revealed an accumulation of profibrotic macrophages and similarities with macrophage populations in idiopathic pulmonary fibrosis. Exposure to SARS-CoV-2 induced a profibrotic phenotype in human monocytes, suggesting a mechanistic link between the virus and fibroproliferative ARDS.
Article Immunology

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Tamara S. Rodrigues et al.

Summary: The active NLRP3 inflammasome in response to SARS-CoV-2 infection is associated with disease severity in COVID-19 patients, with higher levels of IL-18 and Casp1p20 correlating with poor clinical outcomes. These findings suggest that inflammasomes may serve as markers of disease severity and potential therapeutic targets for COVID-19.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Immunology

Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19

Enrico Brunetta et al.

Summary: In patients with severe COVID-19, elevated levels of long pentraxin PTX3 have been found to be a strong predictor of decreased survival. Myelomonocytic cells and endothelial cells in both blood and lung tissue are major sources of PTX3, with PTX3 plasma concentration serving as an independent prognostic indicator for short-term mortality in COVID-19 patients.

NATURE IMMUNOLOGY (2021)

Article Nutrition & Dietetics

Parenteral fi sh oil: An adjuvant pharmacotherapy for coronavirus disease 2019?

Raquel S. Torrinhas et al.

Summary: The severe response to SARS-CoV-2 may cause hyperinflammation and dysfunction of multiple organs, especially in individuals with chronic lowgrade inflammation. Using oi-3 PUFAs, potentially through parenteral infusion, could be beneficial in managing COVID-19 patients.

NUTRITION (2021)

Review Cardiac & Cardiovascular Systems

Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians

Sabrina Setembre Batah et al.

Summary: COVID-19 caused by SARS-CoV-2 is a global pandemic, with patients progressing from flu-like symptoms to severe acute lung injury characterized by acute and diffuse inflammatory damage to the alveolar-capillary barrier.

RESPIRATORY MEDICINE (2021)

Article Genetics & Heredity

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Anna C. Aschenbrenner et al.

Summary: This study provides novel insights into distinct molecular subgroups or phenotypes that are not simply explained by clinical parameters. Whole blood transcriptomes are shown to be extremely informative for COVID-19 as they capture the major drivers of disease severity, granulocytes.

GENOME MEDICINE (2021)

Review Physiology

Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial

Hildur Arnardottir et al.

Summary: Infection with SARS-CoV-2 can lead to COVID-19, which triggers an immune response causing inflammation, potentially escalating to a systemic hyperinflammatory reaction. Excessive inflammation may result in severe respiratory failure and cardiovascular complications. Omega-3 polyunsaturated fatty acids have the potential to control inflammation and limit the harmful effects of the cytokine storm in COVID-19 patients.

FRONTIERS IN PHYSIOLOGY (2021)

Review Biochemistry & Molecular Biology

COVID-19 and the human innate immune system

Joachim L. Schultze et al.

Summary: The introduction of SARS-CoV-2 into the human population has led to a significant medical and economic crisis. Innate immunity plays a central role in combating the novel virus, with variability in its components contributing to the diverse disease courses observed for COVID-19. Further research into the pathophysiological mechanisms of innate immunity is crucial for the development of diagnostic markers and therapeutic strategies targeting COVID-19.
Article Biochemistry & Molecular Biology

In Silico Study of Polyunsaturated Fatty Acids as Potential SARS-CoV-2 Spike Protein Closed Conformation Stabilizers: Epidemiological and Computational Approaches

Alonso Vivar-Sierra et al.

Summary: Countries with high PUFA intake have lower incidence and higher recovery rates of COVID-19. Both linoleic acid and omega-3 PUFA can stabilize the closed conformation of spike protein, potentially reducing viral entrance to cells and COVID-19 complications.

MOLECULES (2021)

Review Nutrition & Dietetics

Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases

Sachitra K. Ratha et al.

Summary: The ongoing COVID-19 pandemic has led to global trepidation due to its increasing mortality rate with no specific therapies or vaccines currently available. Nutraceuticals, particularly algae-based ones like Spirulina, show promise in boosting immunity and potentially combating viral diseases. These supplements contain various antiviral compounds that could play a role in fighting infections and disease progression.

NUTRITION (2021)

Article Multidisciplinary Sciences

Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry

Anna Goc et al.

Summary: The study demonstrates that polyunsaturated fatty acids interfere with the binding and entry of SARS-CoV-2, with linolenic acid and eicosapentaenoic acid showing significant blocking effects on the virus entry.

SCIENTIFIC REPORTS (2021)

Article Cardiac & Cardiovascular Systems

Rationale and design of the pragmatic randomized trial of icosapent ethyl for high cardiovascular risk adults (MITIGATE)

Andrew P. Ambrosy et al.

Summary: The MITIGATE study aims to assess the real-world clinical effectiveness of pre-treatment with icosapent ethyl (IPE) in preventing or reducing the sequelae of laboratory-confirmed viral upper respiratory infections in high-risk patients with established ASCVD.

AMERICAN HEART JOURNAL (2021)

Review Immunology

When Immunity Kills: The Lessons of SARS-CoV-2 Outbreak

Yassine Taoufik et al.

Summary: SARS-CoV-2 has spread rapidly worldwide since the end of 2019, with most infected individuals experiencing mild or asymptomatic disease, while a minority, especially the elderly, may develop severe illness leading to ARDS. Specific T cell responses play a crucial role in virus clearance but may also contribute to the pathogenesis of ARDS.

FRONTIERS IN IMMUNOLOGY (2021)

Editorial Material Medicine, General & Internal

The Potential Future of the COVID-19 Pandemic Will SARS-CoV-2 Become a Recurrent Seasonal Infection?

Christopher J. L. Murray et al.

Summary: The viewpoint discusses the possibility of COVID-19 becoming a seasonal disease like influenza and suggests strategies to mitigate the consequences for communities and health systems, including changes in surveillance methods, medical and public health responses, and socioeconomic programs.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, Research & Experimental

The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial

Saeid Doaei et al.

Summary: This study investigated the effects of n3-PUFA supplementation on critically ill patients with COVID-19. The results suggest that Omega-3 supplementation can improve certain biochemical and inflammatory markers, as well as increase survival rates in critically ill patients.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Review Immunology

The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome

Anna Kosyreva et al.

Summary: Macrophages play a crucial role in COVID-19, especially in cases complicated by ARDS. Macrophage activation syndrome is predominantly caused by massive activation of macrophages. Reprogrammed macrophages with stable pro- or anti-inflammatory phenotypes may have potential utility in the treatment of ARDS.

FRONTIERS IN IMMUNOLOGY (2021)

Review Nutrition & Dietetics

Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021

Ivana Djuricic et al.

Summary: Oxidative stress and inflammation are important contributors to chronic non-communicable diseases. Different types of fatty acids have varying effects on chronic diseases, with moderate intake of Ω-6 fatty acids lowering the risk of cardiovascular diseases and Ω-3 fatty acids helping to reduce inflammation levels.

NUTRIENTS (2021)

Article Medicine, Research & Experimental

SARS-CoV-2-associated ssRNAs activate inflammation and immunity via TLR7/8

Valentina Salvi et al.

Summary: The inflammatory and IFN pathways of innate immunity are crucial in the resistance and pathogenesis of COVID-19. Single-stranded RNA fragments from the SARS-CoV-2 genome were identified as direct activators of endosomal TLR7/8 and MyD88 pathway, inducing human DC activation and inflammatory responses. The virus endosomal processing products can potentiate IFN and inflammatory responses, playing a key role in host resistance and COVID-19 pathogenesis.

JCI INSIGHT (2021)

Article Multidisciplinary Sciences

A randomized trial of icosapent ethyl in ambulatory patients with COVID-19

Andrew Kosmopoulos et al.

Summary: This study found that icosapent ethyl significantly reduced high-sensitivity C-reactive protein levels and improved symptoms in ambulatory COVID-19 patients, suggesting an early anti-inflammatory effect in this population.

ISCIENCE (2021)

Review Biochemistry & Molecular Biology

The roles of lipids in SARS-CoV-2 viral replication and the host immune response

Katherine N. Theken et al.

Summary: This study summarizes the roles of lipids in viral entry, membrane remodeling, and modulation of host immune responses. It also identifies gaps in research on the regulation of COVID-19 viral burden and highlights key areas where lipids offer therapeutic potential.

JOURNAL OF LIPID RESEARCH (2021)

Review Critical Care Medicine

Immunonutrition for Adults With ARDS: Results From a Cochrane Systematic Review and Meta-Analysis

Ahilanandan Dushianthan et al.

RESPIRATORY CARE (2020)

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

Editorial Material Immunology

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Meijuan Zheng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

Giovanni Messina et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Letter Nutrition & Dietetics

Parenteral Fish-Oil Emulsions in Critically Ill COVID-19 Emulsions

Bruce R. Bistrian

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2020)

Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Severe Covid-19

David A. Berlin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pathology

The Overlooked Storm in Coronavirus Disease 2019 (COVID-19)?

Bruce D. Hammock et al.

AMERICAN JOURNAL OF PATHOLOGY (2020)

Review Biochemistry & Molecular Biology

Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19

Marcelo M. Rogero et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

Article Multidisciplinary Sciences

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jerome Hadjadj et al.

SCIENCE (2020)

Review Infectious Diseases

Omega 3 Fatty Acids and COVID-19: A Comprehensive Review

Donald Hathaway et al.

INFECTION AND CHEMOTHERAPY (2020)

Review Immunology

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

Tomoaki Ishihara et al.

INTERNATIONAL IMMUNOLOGY (2019)

Review Chemistry, Medicinal

Effects of Fish n-3 PUFAs on Intestinal Microbiota and Immune System

Cinzia Parolini

MARINE DRUGS (2019)

Article Biochemistry & Molecular Biology

Endogenous n-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8+ T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice

Kyung Won Kang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Effects of Omega-3 Fatty Acids on Immune Cells

Saray Gutierrez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, General & Internal

Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury

Wen Tan et al.

CHINESE MEDICAL JOURNAL (2018)

Article Biochemistry & Molecular Biology

Resolution of inflammation and sepsis survival are improved by dietary Omega-3 fatty acids

Andreas Koerner et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Multidisciplinary Sciences

The effects of diets enriched in omega-3 polyunsaturated fatty acids on systemic vaccinia virus infection

Gwendolyn J. B. Jones et al.

SCIENTIFIC REPORTS (2017)

Review Infectious Diseases

Modulation of host defence against bacterial and viral infections by omega-3 polyunsaturated fatty acids

Marie-Odile Husson et al.

JOURNAL OF INFECTION (2016)

Review Medicine, General & Internal

Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-Targeted Cancer Therapy

Donatella D'Eliseo et al.

JOURNAL OF CLINICAL MEDICINE (2016)

Review Immunology

Specialized pro-resolving mediators: endogenous regulators of infection and inflammation

Maria C. Basil et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Review Biochemistry & Molecular Biology

Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages

Kaori L. Honda et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2015)

Review Biotechnology & Applied Microbiology

Dietary omega-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer

Nicolo Merendino et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Critical Care Medicine

Impact of oral omega-3 fatty acids supplementation in early sepsis on clinical outcome and immunomodulation

Mohamed Hosny et al.

EGYPTIAN JOURNAL OF CRITICAL CARE MEDICINE (2013)

Article Critical Care Medicine

A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury

Renee D. Stapleton et al.

CRITICAL CARE MEDICINE (2011)

Review Pharmacology & Pharmacy

Fatty acids and inflammation: The cutting edge between food and pharma

Philip C. Calder

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

The Impact of Membrane Lipid Composition on Macrophage Activation in the Immune Defense against Rhodococcus equi and Pseudomonas aeruginosa

Axel Schoeniger et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

Article Medicine, General & Internal

Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury

Todd W. Rice et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Article Nutrition & Dietetics

Impact of the omega-3 to omega-6 Polyunsaturated Fatty Acid Ratio on Cytokine Release in Human Alveolar Cells

Paolo Cotogni et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2011)

Article Critical Care Medicine

Efficacy and safety of parenteral omega 3 fatty acids in ventilated patients with acute lung injury

Ajay Gupta et al.

INDIAN JOURNAL OF CRITICAL CARE MEDICINE (2011)

Article Nutrition & Dietetics

Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells

Ahmad Saedisomeolia et al.

BRITISH JOURNAL OF NUTRITION (2009)

Article Nutrition & Dietetics

Fish Oil-Fed Mice Have Impaired Resistance to Influenza Infection

Nicole M. J. Schwerbrock et al.

JOURNAL OF NUTRITION (2009)

Article Nutrition & Dietetics

Dietary Polyunsaturated Fatty Acids Modulate Resistance to Mycobacterium tuberculosis in Guinea Pigs

Christine T. Mc Farland et al.

JOURNAL OF NUTRITION (2008)

Article Nutrition & Dietetics

The Use of an Inflammation-Modulating Diet in Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome: A Meta-Analysis of Outcome Data

Alessandro Pontes-Arruda et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2008)

Review Immunology

Innate immunity, macrophage activation, and atherosclerosis

Zhong-qun Yan et al.

IMMUNOLOGICAL REVIEWS (2007)

Article Biochemistry & Molecular Biology

Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules

Saame Raza Shaikh et al.

JOURNAL OF LIPID RESEARCH (2007)

Article Nutrition & Dietetics

n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases

Philip C. Calder

AMERICAN JOURNAL OF CLINICAL NUTRITION (2006)

Article Critical Care Medicine

Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis

K Mayer et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)