Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/jcm11247507
Keywords
cuproptosis; clear cell renal cell carcinoma; prognosis; signature; cell cycle
Categories
Funding
- National Natural Science Foundation of China
- [82172920]
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Cuproptosis and its related genes (CRGs) play a significant role in the prognosis of clear cell renal cell carcinoma patients. A CRG signature was constructed to predict patient survival, and it was associated with cell cycle and mitotic signaling pathways.
Cuproptosis is a newly discovered type of cell death. The role and potential mechanism of Cuproptosis-related genes (CRGs) in the prognosis of cancer patients are not fully understood. In this study, we included two cohorts of clear cell renal cell carcinoma patients, TCGA and E-MTAB-1980. The TCGA cohort is used as a training set to construct a CRG signature using the LASSO-cox regression analysis, and E-MTAB-1980 is used as a cohort for verification. A total of eight genes (FDX1, LIAS, LIPT1, DLAT, PDHA1, MTF1, GLS, CDKN2A) were screened to construct a prognostic model in the TCGA cohort. There is a significant difference in OS (p < 0.0001) between the high and low cuproptosis score group, and a similar difference is also observed in the OS (p = 0.0054) of the E-MTAB-1980 cohort. The area under the ROC curves (AUC) were 0.87, 0.82, and 0.78 at 1, 3, and 5 years in the TCGA cohort, respectively. Finally, gene set enrichment analysis revealed that CRGs were associated with cell cycle and mitotic signaling pathways.
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