Survival of Myocardial Infarction Patients with Diabetes Mellitus at the Invasive Era (Results from the Varosmajor Myocardial Infarction Registry)

Article Cardiac & Cardiovascular Systems

Cardiovascular Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists in Older Patients in Routine Clinical Care With or Without History of Atherosclerotic Cardiovascular Diseases or Heart Failure

Phyo T. Htoo et al.

Summary: This study evaluated the relative cardiovascular effectiveness of SGLT2i and GLP-1RA in routine care populations with atherosclerotic cardiovascular diseases (CVDs) or heart failure (HF). The results showed that SGLT2i reduced the risk of hospitalized HF in patients with a history of HF but no CVD. However, GLP-1RA was associated with lower occurrence of atherosclerotic CVD events in patients without prior CVD or HF.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

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Editorial Material Medicine, General & Internal

In CV disease, GLP-1 RAs and SGLT2 inhibitors reduce CV mortality

Michelle D. Kelsey et al.

ANNALS OF INTERNAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Vascular hyperacetylation is associated with vascular smooth muscle dysfunction in a rat model of non-obese type 2 diabetes

Maria Alicia Carrillo-Sepulveda et al.

Summary: The study demonstrated that vascular hyperacetylation is associated with vascular smooth muscle cell dysfunction in advanced type 2 diabetes mellitus. Inhibition of hyperacetylation by garcinol reduced high glucose-induced ROS production in VSMCs, highlighting a potential novel therapeutic approach for diabetic vascular complications.

MOLECULAR MEDICINE (2022)

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Article Endocrinology & Metabolism

Effects of metformin on changes of miR-19a and miR-221 expression associated with myocardial infarction in patients with type 2 diabetes

Fatemeh Mansouri et al.

Summary: This study measured the expression levels of two microRNAs associated with the risk of MI and vascular stenosis in both metformin users and non-users with MI. The results showed a significant decrease in the expression levels of miR-221 and miR-19a in diabetic patients using metformin. These microRNAs could serve as potential biomarkers for MI in patients with type 2 diabetes.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2022)

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Article Cardiac & Cardiovascular Systems

The impact of normal range estimated glomerular filtration rate on mortality in selected patients undergoing coronary angiography - a long-term follow-up

Lior Zornitzki et al.

Summary: This study found that a decrease in eGFR, even within the normal range, is inversely associated with long-term all-cause mortality, with a hazard ratio of 1.32 for every decrease of 10 ml/min/1.73(2) in eGFR. Lower eGFR values were also associated with increased long-term mortality, showing a graded association.

CORONARY ARTERY DISEASE (2021)

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Review Cardiac & Cardiovascular Systems

Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease

Divyatha Arun et al.

Summary: Diabetes mellitus is associated with a reduced risk of aortic aneurysm development, potentially due to protective mechanisms such as endothelial dysfunction, chronic hyperglycemia, and insulin resistance. Oral hypoglycemic agents may also have a protective effect against aortic aneurysms, as suggested by the literature.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Pharmacology & Pharmacy

Up-Regulation of Cell-Free MicroRNA-1 and MicroRNA-221-3p Levels in Patients with Myocardial Infarction Undergoing Coronary Angiography

Fatemeh Mansouri et al.

Summary: This study aimed to measure the expression of microRNA-1 and microRNA-221-3p in MI patients, finding that these microRNAs could be informative biomarkers positively correlated with artery stenosis in MI.

ADVANCED PHARMACEUTICAL BULLETIN (2021)

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Article Cardiac & Cardiovascular Systems