Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Article Cardiac & Cardiovascular Systems

Female gender and mortality in ST-segment-elevation myocardial infarction treated with primary PCI

Umberto Paradossi et al.

Summary: The study revealed significant gender differences among STEMI patients treated with PPCI, with women having a higher risk of both all-cause death and cardiac mortality at 30-day and 1-year follow-up compared to men.

JOURNAL OF CARDIOVASCULAR MEDICINE (2022)

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Article Public, Environmental & Occupational Health

Changes in mortality trends amongst common diseases during the COVID-19 pandemic in Sweden

Michael Axenhus et al.

Summary: The study found seasonal increased mortality within neurological diseases due to COVID-19, while mortality rates for infectious diseases, tumors, and cardiac diseases decreased. Changes in mortality trends for several common diseases were observed during the pandemic, indicating the diverse impact of COVID-19 on different health conditions.

SCANDINAVIAN JOURNAL OF PUBLIC HEALTH (2022)

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Article Biochemistry & Molecular Biology

Sex-Related Factors in Cardiovascular Complications Associated to COVID-19

Francesca Megiorni et al.

Summary: This review discusses the gender differences in COVID-19, highlighting the impact of gender on susceptibility, disease severity, and treatment outcomes. The relationship between gender and cardiovascular diseases in COVID-19 is particularly important, and gender also affects the variability of certain biomarkers. Gendered medicine plays a significant role in developing personalized prevention, evaluation, and treatment strategies.

BIOMOLECULES (2022)

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Article Cardiac & Cardiovascular Systems

Impact of the Admission Pathway on the Gender- Related Mortality of Patients With ST-Elevation Myocardial Infarction

Simcha R. Meisel et al.

Summary: Mortality of women with ST-elevation myocardial infarction (STEMI) is higher than that of men, possibly due to older age and co-morbidities. A study found that women suspected of STEMI benefit from transportation by the emergency medical service (EMS), and it is recommended for them to use this pathway exclusively.

AMERICAN JOURNAL OF CARDIOLOGY (2022)

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Article Immunology

Clinical Characteristics of Refractory Coronavirus Disease 2019 in Wuhan, China

Pingzheng Mo et al.

Summary: This study aimed to clarify the characteristics of patients with refractory COVID-19, finding that these patients were older, more likely to be male, and had more underlying comorbid conditions. Patients with refractory disease required more aggressive treatments such as oxygen therapy and mechanical ventilation.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Cardiac & Cardiovascular Systems

Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients

Angelo Silverio et al.

Summary: This meta-analysis suggests that older age and diabetes are associated with a higher risk of in-hospital mortality in patients infected with SARS-CoV-2. Conversely, male sex, hypertension, and smoking did not independently correlate with fatal outcomes.

BMC CARDIOVASCULAR DISORDERS (2021)

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Article Cardiac & Cardiovascular Systems

Impact of the COVID-19 Pandemic on Door-to-Balloon Time for Primary Percutaneous Coronary Intervention - Results From the Singapore Western STEMI Network -

Nicholas W. S. Chew et al.

Summary: The COVID-19 pandemic and outbreak response measures have negatively impacted the efficiency of PPCI services. This study highlights the importance of focusing efforts on reducing D2B time while upholding infection control measures.

CIRCULATION JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Management of STEMI during the COVID-19 pandemic: Lessons learned in 2020 to prepare for 2021*, **

Vardhmaan Jain et al.

Summary: During the COVID-19 pandemic, challenges in managing STEMI have emerged due to social distancing measures and restricted access to healthcare services, potentially leading to delayed treatment and worse outcomes for patients. Solutions for adhering to evidence-based therapies are discussed as the pandemic progresses into 2021.

TRENDS IN CARDIOVASCULAR MEDICINE (2021)

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Article Pharmacology & Pharmacy

Vitamin D deficiency is associated with impaired reperfusion in STEMI patients undergoing primary percutaneous coronary intervention

Monica Verdoia et al.

Summary: This study suggests that lower levels of vitamin D in STEMI patients undergoing pPCI are independently associated with impaired reperfusion, potentially necessitating a higher level of treatment. Future dedicated studies are needed to further explore the prognostic implications of hypovitaminosis D in these patients and identify potential therapeutic options.

VASCULAR PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Predictors of Mortality and Long-Term Outcome in Patients with Anterior STEMI: Results from a Single Center Study

Giulia Ferrante et al.

Summary: Anterior ST segment elevation myocardial infarction (A-STEMI) carries the worst prognosis among all infarct sites due to larger infarct size and higher cardiac enzyme release. Predictors of in-hospital mortality include LV-EF, baseline eGFR, female gender, and cardiogenic shock at admission, while predictors of long-term mortality include age, CAD extension, and LV-EF. Patients with cardiogenic shock at admission have significantly higher mortality rates, while complete revascularization in multivessel disease patients did not show any advantages for short- or long-term mortality compared to culprit-only strategy during percutaneous coronary intervention.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Gender differences with short-term vs 12 months dual antiplatelet therapy in patients with acute coronary syndrome treated with the COMBO dual therapy stent: 2-years follow-up results of the REDUCE trial

M. Verdoia et al.

Summary: In the REDUCE trial, a 3-month DAPT strategy offers comparable results to a standard 12-month DAPT in both male and female ACS patients at 2 years of follow-up.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Article Medicine, General & Internal