4.7 Article

Anlotinib Suppressed Ovarian Cancer Progression via Inducing G2/M Phase Arrest and Apoptosis

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer

Jiawen Zhang et al.

Summary: The study identified that elevated USP35 levels in ovarian cancer correlate with reduced CD8(+) T cell infiltration and poor prognosis in patients. Silencing USP35 enhances STING activity, increases type I interferon expression, and directly deubiquitinates and inactivates STING. Furthermore, USP35 sensitizes ovarian cancer cells to DNA-damage chemotherapeutic drug cisplatin, suggesting its potential as a therapeutic target for ovarian cancer.

CELL DEATH AND DIFFERENTIATION (2021)

Article Oncology

Anlotinib as a promising inhibitor on tumor growth of oral squamous cell carcinoma through cell apoptosis and mitotic catastrophe

Zhaoming Deng et al.

Summary: The tyrosine kinase inhibitor Anlotinib shows antitumor effects on oral squamous cell carcinoma cells through apoptotic pathway and mitotic catastrophe pattern, providing promising potential therapy for patients with OSCC.

CANCER CELL INTERNATIONAL (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Biochemistry & Molecular Biology

The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer

Zhijian Jin et al.

Summary: In this study, anlotinib inhibited gastric cancer (GC) cell growth by inducing apoptosis and G2/M phase arrest in a dose- and time-dependent manner. The interaction between epithelial and stromal cells in the tumor microenvironment affects the response of GC cells to anlotinib. Secreted lactate from GC cells activates cancer-associated fibroblasts (CAFs) to produce BDNF in a NF-kappa B-dependent manner, reducing the sensitivity of GC cells to anlotinib. Targeting the BDNF-TrkB pathway increased the sensitivity of GC cells to anlotinib in a human patient-derived organoid model.

REDOX BIOLOGY (2021)

Article Cell Biology

Anlotinib exerts anti-cancer efficiency on lung cancer stem cells in vitro and in vivo through reducing NF-κB activity

Zhuohong Li et al.

Summary: Anlotinib demonstrates potent anti-cancer effects against lung cancer stem cells by inhibiting cell growth, inducing apoptosis, and reducing stemness-associated markers. The underlying mechanism may involve the suppression of NF-kappa B activity.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Cell Biology

Directly targeting c-Myc contributes to the anti-multiple myeloma effect of anlotinib

Yang Cao et al.

Summary: The study demonstrates that anlotinib exhibits significant anti-myeloma effects by inducing cell cycle arrest, apoptosis, and inhibiting multiple signaling pathways. Notably, it also targets c-Myc and enhances ubiquitin proteasomal degradation, leading to apoptosis. Additionally, anlotinib shows cytotoxicity against bortezomib-resistant MM cells, suggesting its potential clinical application for human MM treatment.

CELL DEATH & DISEASE (2021)

Article Oncology

The role of anlotinib-mediated EGFR blockade in a positive feedback loop of CXCL11-EGF-EGFR signalling in anaplastic thyroid cancer angiogenesis

Juyong Liang et al.

Summary: This study identified a new role of anlotinib in angiogenesis of anaplastic thyroid cancer by targeting the CXCL11-EGF-EGFR positive feedback loop, leading to more efficient inhibition of hypoxia-induced angiogenesis. This provides mechanistic insight into the interaction between cancer cells and endothelial cells in ATC.

BRITISH JOURNAL OF CANCER (2021)

Article Biochemistry & Molecular Biology

Suppressed mitochondrial respiration via NOX5-mediated redox imbalance contributes to the antitumor activity of anlotinib in oral squamous cell carcinoma

Zhexun Huang et al.

Summary: Anlotinib demonstrates promising anticancer activity in oral squamous cell carcinoma by suppressing mitochondrial respiration, inducing redox imbalance through NOX5, and inhibiting the AKT/eIF2α pathway.

JOURNAL OF GENETICS AND GENOMICS (2021)

Article Oncology

Anlotinib suppresses metastasis and multidrug resistance via dual blockade of MET/ABCB1 in colorectal carcinoma cells

Lin-Hai Yan et al.

Summary: Anlotinib, a selective multi-targeted tyrosine kinase inhibitor, shows therapeutic effects on metastatic colorectal cancer by improving chemo-sensitivity, inhibiting proliferation, and suppressing metastasis of CRC cells. In addition to its effects on the MET signaling pathway, anlotinib also prevents angiogenesis, cell migration, and multidrug resistance in CRC. This study suggests that a combination of anlotinib with anti-cancer drugs could provide a novel treatment strategy for CRC patients with metastasis.

JOURNAL OF CANCER (2021)

Article Oncology

The forefront of ovarian cancer therapy: update on PARP inhibitors

M. R. Mirza et al.

ANNALS OF ONCOLOGY (2020)

Article Biotechnology & Applied Microbiology

Anlotinib as Exploratory Therapy for Platinum-Resistant Ovarian Cancer: A Retrospective Study on Efficacy and Safety

Jing Ni et al.

ONCOTARGETS AND THERAPY (2020)

Review Medicine, General & Internal

Treatment of epithelial ovarian cancer

Lindsay Kuroki et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Article Oncology

Antitumor effects of anlotinib in thyroid cancer

Xianhui Ruan et al.

ENDOCRINE-RELATED CANCER (2019)

Review Medicine, General & Internal

Epithelial ovarian cancer

Stephanie Lheureux et al.

LANCET (2019)

Editorial Material Medicine, General & Internal

PARP inhibitors for targeted treatment in ovarian cancer

Don S. Dizon

LANCET (2017)

Review Biochemistry & Molecular Biology

p21: A Two-Faced Genome Guardian

Alexandros G. Georgakilas et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Article Oncology

Treatment of recurrent ovarian cancer

S. Pignata et al.

ANNALS OF ONCOLOGY (2017)