Journal
SCIENCE ADVANCES
Volume 8, Issue 50, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.add2185
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Funding
- National Institute of Mental Health [K99MH127296, R21MH106799, R01MH113550, RF1MH116920, R01MH120482, R01MH107703, R01MH112847, R37MH125829, R01EB022573, R01MH107235, R01MH119219, R01MH119185, R01MH120174, R01MH113565, RC2MH089983, RC2MH089924]
- NARSAD Young Investigator from the Brain & Behavior Research Foundation [28995]
- Swartz Foundation
- John D. and Catherine T. MacArthur Foundation
- Penn-CHOP Lifespan Brain Institute
- NSF [DGE-1321851]
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Cortical variations in cytoarchitecture may shape the sensory-fugal axis and influence brain connectivity and signal propagation. This study used network control theory to reveal an asymmetry in the energy required for bottom-up and top-down signal transmission, which was related to the connectome topology and decreased throughout youth.
Cortical variations in cytoarchitecture form a sensory-fugal axis that shapes regional profiles of extrinsic con-nectivity and is thought to guide signal propagation and integration across the cortical hierarchy. While neuro-imaging work has shown that this axis constrains local properties of the human connectome, it remains unclear whether it also shapes the asymmetric signaling that arises from higher-order topology. Here, we used network control theory to examine the amount of energy required to propagate dynamics across the sensory-fugal axis. Our results revealed an asymmetry in this energy, indicating that bottom-up transitions were easier to complete compared to top-down. Supporting analyses demonstrated that asymmetries were underpinned by a connec-tome topology that is wired to support efficient bottom-up signaling. Lastly, we found that asymmetries cor-related with differences in communicability and intrinsic neuronal time scales and lessened throughout youth. Our results show that cortical variation in cytoarchitecture may guide the formation of macroscopic connectome topology.
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