4.8 Article

High-speed single-exposure time-reversed ultrasonically encoded optical focusing against dynamic scattering

Journal

SCIENCE ADVANCES
Volume 8, Issue 50, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.add9158

Keywords

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Funding

  1. National Key Research and Development Program of China [2019YFA0706301]
  2. National Natural Science Foundation of China [12004446, 92150102, U2001601]
  3. Local Innovation and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01X121]
  4. Open Fund of State Key Laboratory of Information Photonics and Optical Communications (Beijing University of Posts and Telecommunications) [IPOC2020A003]
  5. Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) [SML2022007]

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By developing a quaternary phase encoding scheme, single-exposure time-reversed ultrasonically encoded optical focusing with full-phase modulations is achieved, marking an important step towards in vivo deep tissue applications of wavefront shaping.
Focusing light deep inside live scattering tissue promises to revolutionize biophotonics by enabling deep tissue noninvasive optical imaging, manipulation, and therapy. By combining with guide stars, wavefront shaping is emerging as a powerful tool to make scattering media optically transparent. However, for in vivo biomedical applications, the speeds of existing techniques are still too slow to accommodate the fast speckle decorrelation of live tissue. To address this key bottleneck, we develop a quaternary phase encoding scheme to enable single -exposure time-reversed ultrasonically encode optical focusing with full-phase modulations. Specifically, we focus light inside dynamic scattering media with an average mode time down to 29 ns, which indicates that more than 104 effective spatial modes can be controlled within 1 millisecond. With this technique, we demon-strate in vivo light focusing in between a highly opaque adult zebrafish of 5.1 millimeters in thickness and a ground glass diffuser. Our work presents an important step toward in vivo deep tissue applications of wavefront shaping.

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