Journal
CHEMISTRYSELECT
Volume 7, Issue 44, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202202745
Keywords
heterocyclization; iminodihydrofuran; Michael addition; nucleophilic substitution; thiazolidinone
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The catalyst-free and eco-friendly synthesis of potentially bioactive compounds comprising iminodihydrofuran and thiazolidinone rings has been developed using two strategies from iminodihydrofuran thiosemicarbazones. The methodologies are simple, efficient, inexpensive, and yield good to excellent yields of the polyheteroconjugated products with operational simplicity.
We have developed the catalyst-free and eco-friendly synthesis of potentially bioactive compounds comprising iminodihydrofuran and thiazolidinone rings by subsequent Michael addition/ heterocyclization and nucleophilic substitution/heterocyclization reactions according to two strategies from iminodihydrofuran thiosemicarbazones. The methodologies are simple, efficient and inexpensive affording good to excellent yields of the polyheteroconjugated products with operational simplicity.
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