Catalyst-Free Synthesis of New Iminodihydrofurans Containing Thiazolidinone Ring

We have developed the catalyst-free and eco-friendly synthesis of potentially bioactive compounds comprising iminodihydrofuran and thiazolidinone rings by subsequent Michael addition/ heterocyclization and nucleophilic substitution/heterocyclization reactions according to two strategies from iminodihydrofuran thiosemicarbazones. The methodologies are simple, efficient and inexpensive affording good to excellent yields of the polyheteroconjugated products with operational simplicity.

Automated summary

The catalyst-free and eco-friendly synthesis of potentially bioactive compounds comprising iminodihydrofuran and thiazolidinone rings has been developed using two strategies from iminodihydrofuran thiosemicarbazones. The methodologies are simple, efficient, inexpensive, and yield good to excellent yields of the polyheteroconjugated products with operational simplicity.