SCuNPs-Catalyzed Solventless Oxidative [3+2] Azide-Olefin Cycloaddition: An Efficient Protocol For Di- And Trisubstituted 1,2,3-Triazole Synthesis

A starch capped copper nanoparticles (SCuNPs) promoted solvent free methodology has been developed for oxidative [3+2] azide-olefin cycloaddition reaction. The reactions employ atmospheric O-2/DMSO as oxidant to furnish an assortment of disubstituted and trisubstituted 1,2,3-triazoles. This method is well-suited not only with acyclic terminal olefins, but also with cyclic and open chain internal olefins. The proposed mechanism was validated with the help of DFT calculations. The triazole formation proceeds through exergonic pathway and the activation barriers are not very high which helps in the easy formation of triazole derivative.

Automated summary

A solvent-free methodology utilizing starch capped copper nanoparticles (SCuNPs) has been developed for oxidative [3+2] azide-olefin cycloaddition reactions, producing a variety of disubstituted and trisubstituted 1,2,3-triazoles. The mechanism of triazole formation was validated through DFT calculations, showing that the process proceeds through an exergonic pathway with manageable activation barriers.