Journal
CHEMISTRYSELECT
Volume 7, Issue 44, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202203340
Keywords
alkene; annulation; Morita-Baylis-Hillman carbonate; phosphine; spirocyclic compound
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Funding
- National Natural Science Foundation of China
- [21871293]
- [22071264]
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Various multifunctional chromone-spiroindolinone-cyclopentene derivatives were synthesized through a phosphine-catalyzed reaction, showing excellent diastereoselectivities and potential application in the synthesis of biologically important compounds.
Various multifunctional chromone-spiroindolinone-cyclopentene derivatives were synthesized through a phosphine-catalyzed (3+2) annulation of Morita-Baylis-Hillman (MBH) carbonates with oxindole-chromones in generally high yields with good to excellent diastereoselectivities. The synthetic method has several advantages such as mild reaction conditions, wide substrate scope, high yields and good stereoselectivity. The gram-scale reaction indicated the synthetic method could be a practical tool for synthesis of spirocyclic compounds and will find a nice application in the synthesis of diverse biologically important compounds.
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