Journal
FOOD BIOSCIENCE
Volume 51, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fbio.2022.102201
Keywords
Fermented Psidium guajava leaves; Phenolic extract; Gut microbiota; Host metabolism; Hypoglycemic; Hypolipidemic
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The phenolic extract from fermented Psidium guajava leaves (PFGL) improves diabetes by modulating gut microbiota and glucose-lipid metabolism.
The phenolic extract from fermented Psidium guajava leaves (PFGL) helps to improve diabetes; however, its hypoglycemic and hypolipidemic mechanisms remain unclear. In this study, gut microbiota modulation and glucose-lipid metabolism was investigated. The results showed that dietary supplement of PFGL enriched in quercetin glucosides significantly improved serum glucose-lipid profiles as well as insulin resistance in diabetic mice. The gut microbiota of diabetic mice was modulated by PFGL (200 mg/kg), causing an abundance of Bacteroidetes, Prevotellaceae, and Alistipes and a reduced the presence of Firmicutes and Streptococcus. Increased levels of short-chain fatty acids (SCFA) activated G protein-coupled receptor signaling that induced peptide YY release to promote insulin secretion. Diabetes-induced serum metabolite disorders that are involved in glycer-ophospholipid metabolism and tryptophan metabolism were restored by PFGL. The protein expression of metabolic enzymes including phospho-adenosine 5'-monophosphate-activated protein kinase, fatty acid syn-thase, acyl-coenzyme A oxidase, and diacylglycerol aeyltransferase 2 were also regulated to promote glucose -lipid metabolism. In particular, gut microbiota enriched with Alistipes genera and SCFA metabolic regulation were closely correlated with diabetes-related indicators. These findings provide a theoretical support for the development and application of PFGL for the treatment of diabetes.
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