4.3 Article

Identification of a novel specific small-molecule melanocortin-2-receptor antagonist

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia

Richard J. Auchus et al.

Summary: This study examined the safety, tolerability, and efficacy of crinecerfont as a selective CRF1R antagonist in patients with 21OHD. The results showed that crinecerfont treatment for 14 days significantly reduced adrenal androgen production and improved clinical symptoms in patients.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Review Endocrinology & Metabolism

Congenital Adrenal Hyperplasia-Current Insights in Pathophysiology, Diagnostics, and Management

Hedi L. Claahsen-van der Grinten et al.

Summary: Congenital adrenal hyperplasia is a group of autosomal recessive disorders affecting cortisol biosynthesis, with the most common form caused by steroid 21-hydroxylase deficiency due to mutations in CYP21A2. Recent developments include advancements in understanding steroidogenic pathways, improvements in diagnostic measurements, and exploration of alternative medications and treatments for CAH patients.

ENDOCRINE REVIEWS (2022)

Article Endocrinology & Metabolism

Pathophysiology of melanocortin receptors and their accessory proteins

T. V. Novoselova et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Endocrinology & Metabolism

Poor compliance and increased mortality, depression and healthcare costs in patients with congenital adrenal hyperplasia

Sara Jenkins-Jones et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2018)

Article Veterinary Sciences

Melanocortin 2 receptor antagonists in canine pituitary-dependent hypercortisolism: in vitro studies

Karin Sanders et al.

VETERINARY RESEARCH COMMUNICATIONS (2018)

Article Endocrinology & Metabolism

Promiscuity among the MRAPs

Adrian J. L. Clark et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2017)

Review Clinical Neurology

Cushing's disease: pathobiology, diagnosis, and management

Russell R. Lonser et al.

JOURNAL OF NEUROSURGERY (2017)

Article Endocrinology & Metabolism

Structure/function studies on the activation of the rainbow trout melanocortin-2 receptor

Liang Liang et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2015)

Article Cell Biology

Development of potent selective competitive-antagonists of the melanocortin type 2 receptor

Elise Bouw et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2014)

Article Endocrinology & Metabolism

Health Status of Adults with Congenital Adrenal Hyperplasia: A Cohort Study of 203 Patients

Wiebke Arlt et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)

Article Multidisciplinary Sciences

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

Li F. Chan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Endocrinology & Metabolism

Development of an Adrenocorticotropin-Responsive Human Adrenocortical Carcinoma Cell Line

Jeniel Parmar et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)