Electroconvulsive therapy for obsessive-compulsive disorder: A retrospective study

BackgroundChronic mental diseases such as obsessive-compulsive disorder (OCD) are associated with a high disability rate. Some patients still do not improve their symptoms even with adequate cognitive-behavioral therapy and drug treatment. In the treatment of OCD, electroconvulsive therapy (ECT) is not considered a neuromodulation modality with sufficient evidence. ObjectiveThis retrospective study aimed to determine the efficacy and associated risk factors of ECT in OCD patients. Materials and methodsThe study included 21 OCD patients who underwent ECT at a high-volume center in China between January 2009 and December 2020. The demographics and clinical characteristics of the patients were assessed using descriptive statistics. Based on Clinical Global Impressions-Improvement scale, patients were categorized into response and non-response groups. Clinical and demographic characteristics of two groups of patients were compared. ResultsAn analysis of 21 patients was conducted. In total, 12 patients (57.1%) responded to ECT, 11 patients (52.4%) reported side effects, and an average of 7 ECT sessions were administered. In terms of demographic, there was no statistically significant difference between the two groups. It is noteworthy that the non-response group reported more depression and schizophrenia related disorders comorbidities than the response group (chi(2) = 6.252, P = 0.041). ConclusionThe effectiveness of ECT in treating OCD is limited, especially in patients with refractory symptoms. Comorbidity with other mental disorders may affect the efficacy of ECT.

Automated summary

This study aimed to investigate the efficacy and risk factors of ECT in treating OCD patients in a high-volume center in China. The results showed that 57.1% of patients responded to ECT, with 52.4% reporting side effects. There was no statistically significant difference in demographics between the response and non-response groups, but patients with comorbid depression and schizophrenia related disorders showed poorer efficacy with ECT.