Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.1069057
Keywords
osteoarthritis; JAK; STAT pathway; inflammation; cartilage remodeling; SOCS
Categories
Funding
- Science and Technology Plan of Jiangxi Health Commission
- Guiding Science and Technology Plan Project of Ganzhou City
- Gannan Medical College Science and Technology Innovation Construction Team
- [220210619]
- [202210897]
- [202210900]
- [GZ2021ZSF021]
- [TS202002]
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Osteoarthritis is an age-related degenerative disease that is influenced by inflammation and immunity. The JAK/STAT pathway plays a significant role in the pathological development of OA and may serve as a therapeutic target.
Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered biomechanics. Inflammation and immunity play an important role in the pathogenesis of OA. JAK/STAT pathway is one of the most prominent intracellular signaling pathways, regulating cell proliferation, differentiation, and apoptosis. Inflammatory factors can act as the initiators of JAK/STAT pathway, which is implicated in the pathophysiological activity of chondrocyte. In this article, we provide a review on the importance of JAK/STAT pathway in the pathological development of OA. Potentially, JAK/STAT pathway becomes a therapeutic target for managing OA.
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