4.7 Article

HRAS overexpression predicts response to Lenvatinib treatment in gastroenteropancreatic neuroendocrine tumors

Related references

Note: Only part of the references are listed.
Article Oncology

Lenvatinib suppresses cancer stem-like cells in HCC by inhibiting FGFR1-3 signaling, but not FGFR4 signaling

Taku Shigesawa et al.

Summary: This study demonstrates that lenvatinib reduces CSCs in HCC by inhibiting FGFR1-3 signaling, while not affecting FGFR4 signaling. FGF2 and FGF19 may be involved in maintaining CSCs in HCC through FGFR1-3.

CARCINOGENESIS (2021)

Article Endocrinology & Metabolism

Three-Dimensional Primary Cell Culture: A Novel Preclinical Model for Pancreatic Neuroendocrine Tumors

Simon Leonhard April-Monn et al.

Summary: This study established a novel in vitro 3-dimensional human primary PanNET culture system as a preclinical model for personalized therapy selection. The platform allows multicenter sample collection and drug screening, showing that primary cells isolated from PanNET patients can form islet-like tumoroids in vitro and display varying therapeutic response profiles. The model is believed to be suitable for personalized drug testing in a larger patient cohort, aiding in identifying novel markers predicting treatment response and refining PanNET therapy.

NEUROENDOCRINOLOGY (2021)

Article Oncology

Correlative serum biomarker analyses in the phase 2 trial of lenvatinib-plus-everolimus in patients with metastatic renal cell carcinoma

Chung-Han Lee et al.

Summary: No biomarkers have been established to predict treatment efficacy in renal cell carcinoma (RCC). In an exploratory analysis, composite biomarker scores (CBSs) were constructed and found to significantly predict progression-free survival (PFS) and overall survival (OS) in patients with metastatic RCC receiving lenvatinib-plus-everolimus treatment. The 5-factor CBS may identify patients who would benefit from this treatment approach, but further validation is needed.

BRITISH JOURNAL OF CANCER (2021)

Article Oncology

Lenvatinib in Patients With Advanced Grade 1/2 Pancreatic and Gastrointestinal Neuroendocrine Tumors: Results of the Phase II TALENT Trial (GETNE1509)

Jaume Capdevila et al.

Summary: The study demonstrates a high treatment response rate with lenvatinib in advanced GEP-NETs patients, particularly in the panNET cohort. The efficacy is significant, providing new evidence for the potential value of lenvatinib in treating advanced GEP-NETS after treatment with other TAs.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Oncology

Epidemiology, Incidence, and Prevalence of Neuroendocrine Neoplasms: Are There Global Differences?

Satya Das et al.

Summary: The purpose of the review is to explore global epidemiologic trends of gastroenteropancreatic neuroendocrine tumors (NETs), looking at differences in incidence, prevalence, distribution, and overall survival between different regions. GEP NET incidence rates are rising steadily in North America, Asia, and Europe, with differences in distribution of NETs among regions. Improved overall survival for GEP NET patients is also observed over time.

CURRENT ONCOLOGY REPORTS (2021)

Editorial Material Cell Biology

The 2019 WHO classification of tumours of the digestive system

Iris D. Nagtegaal et al.

HISTOPATHOLOGY (2020)

Review Biochemistry & Molecular Biology

Lenvatinib for hepatocellular carcinoma: From preclinical mechanisms to anti-cancer therapy

Yan Zhao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Article Gastroenterology & Hepatology

Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma

Masami Yamauchi et al.

Clinical and Translational Gastroenterology (2020)

Article Multidisciplinary Sciences

Pan-cancer whole-genome analyses of metastatic solid tumours

Peter Priestley et al.

NATURE (2019)

Review Pharmacology & Pharmacy

Targeted Systemic Treatment of Neuroendocrine Tumors: Current Options and Future Perspectives

Aura D. Herrera-Martinez et al.

DRUGS (2019)

Review Endocrinology & Metabolism

Management of Gastrointestinal Neuroendocrine Tumors

Rongzhi Wang et al.

CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES (2019)

Review Endocrinology & Metabolism

Targeted therapy of gastroenteropancreatic neuroendocrine tumours: preclinical strategies and future targets

E. T. Aristizabal Prada et al.

ENDOCRINE CONNECTIONS (2018)

Review Cell Biology

Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models

Kenta Kawasaki et al.

DISEASE MODELS & MECHANISMS (2018)

Review Oncology

Treatment options for PNET liver metastases: a systematic review

Giuseppe Nigri et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2018)

Article Oncology

Gastroenteropancreatic Neuroendocrine Tumors

Mauro Cives et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Article Oncology

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

Chantal Pauli et al.

CANCER DISCOVERY (2017)

Review Endocrinology & Metabolism

Novel treatment options for anaplastic thyroid cancer

Poupak Fallahi et al.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2017)

Article Oncology

Peptide Receptor Radionuclide Therapy in the Treatment of Neuroendocrine Tumors

Dik J. Kwekkeboom et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2016)

Article Biochemistry & Molecular Biology

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

Marc van de Wetering et al.

Article Endocrinology & Metabolism

Temozolomide in Advanced Neuroendocrine Neoplasms: Pharmacological and Clinical Aspects

Anna Koumarianou et al.

NEUROENDOCRINOLOGY (2015)

Article Biotechnology & Applied Microbiology

First-line chemotherapy in patients with metastatic gastroenteropancreatic neuroendocrine carcinoma

Alberto Bongiovanni et al.

ONCOTARGETS AND THERAPY (2015)

Article Oncology

Pharmacokinetics and excretion of 14C-lenvatinib in patients with advanced solid tumors or lymphomas

Anne-Charlotte Dubbelman et al.

INVESTIGATIONAL NEW DRUGS (2015)

Article Endocrinology & Metabolism

Angiogenesis in Neuroendocrine Tumors: Therapeutic Applications

Jean-Yves Scoazec

NEUROENDOCRINOLOGY (2013)

Review Oncology

Gastroenteropancreatic neuroendocrine tumours

Irvin M. Modlin et al.

LANCET ONCOLOGY (2008)

Review Pharmacology & Pharmacy

Clinical pharmacokinetics of everolimus

GI Kirchner et al.

CLINICAL PHARMACOKINETICS (2004)