Steroid profiling using liquid chromatography mass spectrometry during adrenal vein sampling in patients with primary bilateral macronodular adrenocortical hyperplasia

Review Endocrinology & Metabolism

Primary bilateral macronodular adrenal hyperplasia: definitely a genetic disease

Isadora P. Cavalcante et al.

Summary: Recent progress in understanding the genetics of PBMAH has led to a better understanding of its pathophysiology and opened new clinical perspectives.

NATURE REVIEWS ENDOCRINOLOGY (2022)

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Review Endocrinology & Metabolism

Cushing's syndrome due to bilateral adrenal cortical disease: Bilateral macronodular adrenal cortical disease and bilateral micronodular adrenal cortical disease

Marta Araujo-Castro et al.

Summary: Cushing's syndrome can be caused by bilateral adrenal cortical disease, which can be classified into macronodular and micronodular types. Surgery is the preferred treatment for macronodular disease, while medical treatment can be used to control micronodular disease. The high-dose dexamethasone suppression test is useful in identifying primary pigmented nodular adrenocortical disease with a certain degree of specificity.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Endocrinology & Metabolism

Influence of cortisol cosecretion on non-ACTH-stimulated adrenal venous sampling in primary aldosteronism: a retrospective cohort study

Daniel Alexander Heinrich et al.

Summary: Cortisol cosecretion may influence non-ACTH-stimulated adrenal venous samplings (AVS) results, potentially leading to misclassified lateralized cases as bilateral. Further research on substitutes for cortisol is needed to understand its effects on clinical outcomes.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2022)

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Article Endocrinology & Metabolism

The role of adrenal venous sampling (AVS) in primary bilateral macronodular adrenocortical hyperplasia (PBMAH): a study of 16 patients

German Rubinstein et al.

Summary: This study evaluated the feasibility of using adrenal venous sampling for guidance of unilateral adrenalectomy in patients with marked adrenal asymmetry in PBMAH. The results showed limited gain of information through AVS in these patients.

ENDOCRINE (2022)

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Article Endocrinology & Metabolism

Role of unilateral adrenalectomy in bilateral adrenal hyperplasias with Cushing's syndrome

Leamarie Meloche-Dumas et al.

Summary: Primary bilateral adrenocortical hyperplasias are rare forms of pituitary ACTH-independent Cushing's syndrome, with treatment options including bilateral adrenalectomy and unilateral adrenalectomy, as well as medical therapies.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Review Psychiatry

DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis

Frederic Dutheil et al.

Summary: DHEA levels increase over time after acute stress, with a peak at the end of stress and a subsequent progressive decrease. Mental stress leads to higher DHEA levels, with women, young people, and obese individuals exhibiting a stronger response. There is no difference in results between blood and saliva measurements.

FRONTIERS IN PSYCHIATRY (2021)

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Article Endocrinology & Metabolism

Volumetric Modeling of Adrenal Gland Size in Primary Bilateral Macronodular Adrenocortical Hyperplasia

Rachel Wurth et al.

Summary: This study conducted volumetric modeling of adrenal gland size in 44 patients with PBMAH, showing a positive correlation between adrenal volume and biochemical disease severity in Black patients, providing a useful tool for assessing PBMAH in this population.

JOURNAL OF THE ENDOCRINE SOCIETY (2021)

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Review Endocrinology & Metabolism

Update on primary bilateral macronodular adrenal hyperplasia (PBMAH)

Lucas Bouys et al.

Summary: PBMAH is a rare and heterogeneous disease characterized by bilateral benign adrenal macronodules, with some cases associated with genetic factors. Rigorous biochemical and imaging assessment is crucial in the management of this disease.

ENDOCRINE (2021)

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Article Endocrinology & Metabolism