Journal
FRONTIERS IN GENETICS
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2023.1076421
Keywords
multiple sclerosis; genomics; transcriptomics; proteomics; metabolomics; disease-modifying treatments; efficacy; safety
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From the perspective of precision medicine, the challenge for the future is to improve the accuracy of diagnosis, prognosis, and prediction of therapeutic responses through the identification of biomarkers. Omics sciences provide innovative approaches for exploring the complexity and heterogeneity of multiple sclerosis (MS). This review examines the current evidence on the application of omics sciences to MS and focuses on biomarkers associated with disease state, exposure to disease-modifying treatments (DMTs), and drug efficacies and safety profiles.
From the perspective of precision medicine, the challenge for the future is to improve the accuracy of diagnosis, prognosis, and prediction of therapeutic responses through the identification of biomarkers. In this framework, the omics sciences (genomics, transcriptomics, proteomics, and metabolomics) and their combined use represent innovative approaches for the exploration of the complexity and heterogeneity of multiple sclerosis (MS). This review examines the evidence currently available on the application of omics sciences to MS, analyses the methods, their limitations, the samples used, and their characteristics, with a particular focus on biomarkers associated with the disease state, exposure to disease-modifying treatments (DMTs), and drug efficacies and safety profiles.
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