4.6 Article

Novel insight of N6-methyladenosine modified subtypes in abdominal aortic aneurysm

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Expression profiling of N6-methyladenosine modified circRNAs in acute myeloid leukemia

Mohammed Awal Issah et al.

Summary: This study investigated the expression profiling of m6A circRNAs in AML and found that circRNA m6A modification may contribute to circRNA regulation in AML.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Review Cell Biology

Emerging role of m(6)A modification in cardiovascular diseases

Liming Peng et al.

Summary: This article summarizes the research progress on the functions and mechanisms of m(6)A methylation in cardiovascular diseases (CVDs), providing references for exploring novel therapeutic approaches and potential biomarkers.

CELL BIOLOGY INTERNATIONAL (2022)

Article Biochemistry & Molecular Biology

Characterization of an Aging-Based Diagnostic Gene Signature and Molecular Subtypes With Diverse Immune Infiltrations in Atherosclerosis

Lei Zhao et al.

Summary: This study conducts a comprehensive analysis of the biological implications of aging-related genes in atherosclerosis (AS). It identifies AS-specific aging-related genes and develops a gene signature for accurate diagnosis of AS. The study also clusters molecular subtypes based on the expression profiling of aging-related genes, which show diverse immune infiltration features. Additionally, it identifies genes associated with immune activation and demonstrates the role of CEBPB in macrophage polarization and foam cell formation. Overall, the study highlights the importance of aging-related genes in diagnosing AS and modulating immune infiltrations.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Article Immunology

Hsa_circ_0087352 promotes the inflammatory response of macrophages in abdominal aortic aneurysm by adsorbing hsa-miR-149-5p

Xiaoying Ma et al.

Summary: This study investigates the role of circRNA in abdominal aortic aneurysms (AAA) and macrophages. The researchers found that hsa_circ_0087352, a circRNA, is up-regulated in human AAA specimens and is related to the inflammatory response in THP-1 macrophages. Further experiments revealed that hsa_circ_0087352 promotes IL-6 transcription and the secretion of inflammatory cytokines by sponging endogenous hsa-miR-149-5p in macrophages, potentially through the ERK/NF-kappa B pathway. Additionally, hsa_circ_0087352 overexpression induces apoptosis in human vascular smooth muscle cells. These findings suggest the potential of hsa_circ_0087352 as a biomarker and therapeutic target for AAA.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Review Biochemistry & Molecular Biology

Targeting the RNA m6A modification for cancer immunotherapy

Xinxin Li et al.

Summary: This article provides an overview of how m(6)A modifications intrinsically affect immune cells and how alterations in tumor cell m(6)A modifications extrinsically affect immune cell responses in the tumor microenvironment (TME). It also discusses strategies for modulating endogenous anti-tumor immunity and reshaping the TME.

MOLECULAR CANCER (2022)

Article Immunology

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner

Zhijia Li et al.

Summary: This study provides the first demonstration of the role of m6A methylation in the pathological process of syphilis and offers new insight into the pathogenesis of TP infection.

FRONTIERS IN IMMUNOLOGY (2022)

Article Oncology

Bioinformatic analyses of the role of m6A RNA methylation regulators in abdominal aortic aneurysm

Changgeng Fu et al.

Summary: m6A regulators play significant roles in the occurrence of abdominal aortic aneurysm (AAA), and investigating m6A patterns may guide future immunotherapy strategies for AAA.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration

Yang Liu et al.

Summary: This study reveals the important role of ALKBH5 in enhancing the intrinsic ability of neutrophil migration for antibacterial innate defense. Deficiency of ALKBH5 results in impaired neutrophil migration, leading to increased mortality and proinflammatory cytokine production in mice with polymicrobial sepsis. Mechanistically, ALKBH5 regulates protein expression of neutrophil migration-related molecules by altering RNA decay, thereby empowering neutrophils with high migration capability.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Cell Biology

G protein-coupled oestrogen receptor promotes cell growth of non-small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling

Yi Shen et al.

Summary: Studies have shown that G protein-coupled estrogen receptor (GPER) plays a role in promoting cell growth in non-small-cell lung cancer (NSCLC) by modulating the NOTCH1 pathway. Mechanistic research has revealed that GPER up-regulates circNOTCH1 expression, inhibits m6A modification of NOTCH1 mRNA, leading to increased stability and translation of NOTCH1, ultimately promoting NSCLC cell growth.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Medicine, Research & Experimental

TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm

Marie Vandestienne et al.

Summary: The study demonstrated that TREM-1 plays a crucial role in the pathophysiology of AAA and could be a potential therapeutic target for the disease in humans.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Biotechnology & Applied Microbiology

Construction of the circRNA-miRNA-mRNA Regulatory Network of an Abdominal Aortic Aneurysm to Explore Its Potential Pathogenesis

Hao Zhang et al.

Summary: This study identified differentially expressed circRNAs, miRNAs, and mRNAs in abdominal aortic aneurysms, and constructed a ceRNA network involving key genes SOD2, CCR7, and PGRMC1. Functional enrichment and pathway analysis suggested these genes as crucial targets for AAA treatment, potentially regulated by specific circRNAs. The study provided insights into the potential pathogenesis of AAA through a circRNA-related competitive endogenous RNA network.

DISEASE MARKERS (2021)

Article Environmental Sciences

Paraquat-induced oxidative stress regulates N6-methyladenosine (m6A) modification of circular RNAs*

Nengzhou Chen et al.

Summary: This study identified a link between m6A modification of circRNAs and PQ-induced oxidative stress, suggesting a specific regulatory network of circRNAs modulating the expression of downstream genes in response to oxidative stress. Further research is needed to explore the molecular mechanisms associated with PQ-induced neurotoxicity.

ENVIRONMENTAL POLLUTION (2021)

Review Immunology

Abdominal Aortic Aneurysm: Roles of Inflammatory Cells

Zhen Yuan et al.

Summary: Abdominal aortic aneurysms (AAAs) are local dilations of the infrarenal segment of aortas, with inflammation playing a central role in their development. In addition to inflammatory cells like T cells, macrophages, and neutrophils, special structures such as inflammasomes and neutrophil extracellular traps are investigated for their roles in aneurysm formation. Understanding the impacts and interactions of these inflammatory cells and structures is crucial for developing new screening and pharmacological interventions for AAA.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA

Benyu Liu et al.

Summary: The newly identified circular RNA circZbtb20 is crucial for the maintenance and function of group 3 innate lymphoid cells (ILC3), with its deletion causing reduced ILC3 numbers and increased susceptibility to bacterial infections. The circZbtb20 enhances the stability of specific mRNA and initiates a signaling pathway to maintain the homeostasis of ILC3.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Cardiac & Cardiovascular Systems

A Novel Mechanism Underlying Inflammatory Smooth Muscle Phenotype in Abdominal Aortic Aneurysm

Dunpeng Cai et al.

Summary: The study identified ADAR1 as a novel regulator of AAA development, showing its interaction with HuR to regulate the stability of MMP2 and MMP9 mRNA, leading to increased MMP levels and activities that may represent a potential new therapeutic target to hinder AAA growth and rupture.

CIRCULATION RESEARCH (2021)

Article Computer Science, Interdisciplinary Applications

Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management

Emrah Akkoyun et al.

Summary: This study analyzed morphological parameters of abdominal aortic aneurysm using CT scans and found that an exponential growth model fitted to the maximum spherical diameter was the best predictor of AAA growth. The model provides valuable information about aneurysm progression and growth rate extrapolation.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2021)

Review Biochemistry & Molecular Biology

Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions

Xin Wang et al.

Summary: N-6-methyladenosine (m(6)A) and circular RNAs (circRNAs) are important players in eukaryotic RNA regulation, with critical roles in cellular and disease processes. Recent research has focused on exploring the crosstalk between m(6)A and circRNAs, with future research directions also being a topic of interest.

MOLECULAR CANCER (2021)

Article Multidisciplinary Sciences

METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells

Hao Song et al.

Summary: The m(6)A methylation protects the homeostasis and tumor immunosurveillance function of NK cells.

NATURE COMMUNICATIONS (2021)

Article Immunology

NPM1 Is a Prognostic Biomarker Involved in Immune Infiltration of Lung Adenocarcinoma and Associated With m6A Modification and Glycolysis

Xu-Sheng Liu et al.

Summary: Overexpression of NPM1 promotes tumor growth and proliferation. NPM1 is a prognostic biomarker in LUAD, associated with tumor stage and prognosis. NPM1 is closely related to m6A modification and glycolysis pathways in LUAD.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Expression Pattern and Clinical Value of Key m6A RNA Modification Regulators in Abdominal Aortic Aneurysm

Tan Li et al.

Summary: The study revealed the expression patterns of m6A regulators METTL14, HNRNPC, and RBM15B in human AAA, with METTL14 and HNRNPC being downregulated and RBM15B being upregulated. The modified genes were enriched in functions such as RNA catabolic process, translation regulation, and focal adhesion, and were associated with immune infiltration and metabolism-autophagy in AAA disease.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Review Biochemistry & Molecular Biology

The Role of N6-Methyladenosine Modified Circular RNA in Pathophysiological Processes

Mei Tang et al.

Summary: circRNA, a type of non-coding RNA generated by a non-canonical splicing event, is highly influenced by m6A modification, which plays a crucial role in various pathophysiological processes. Understanding the regulatory mechanisms of m6A-modified circRNAs can lead to better insights into physiological mechanisms and the development of new biomarkers.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Editorial Material Medicine, General & Internal

Abdominal aortic aneurysms: pathophysiology and clinical issues

Simona Lattanzi

JOURNAL OF INTERNAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs

Lele Zhang et al.

MOLECULAR CANCER (2020)

Review Biochemistry & Molecular Biology

Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm

Rijan Gurung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

METTL3 Induces AAA Development and Progression by Modulating N6-Methyladenosine-Dependent Primary miR34a Processing

Lintao Zhong et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Review Biochemistry & Molecular Biology

Circular RNA: metabolism, functions and interactions with proteins

Wei-Yi Zhou et al.

MOLECULAR CANCER (2020)

Article Cardiac & Cardiovascular Systems

Cellular Mechanisms of Aortic Aneurysm Formation

Raymundo Alain Quintana et al.

CIRCULATION RESEARCH (2019)

Article Hematology

IL (Interleukin)-33 Suppresses Abdominal Aortic Aneurysm by Enhancing Regulatory T-Cell Expansion and Activity

Jingyong Li et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Abdominal aortic aneurysm: update on pathogenesis and medical treatments

Jonathan Golledge

NATURE REVIEWS CARDIOLOGY (2019)

Editorial Material Pharmacology & Pharmacy

MDSC; the Most Important Cell You Have Never Heard Of

R. J. Tesi

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

MODOMICS: a database of RNA modification pathways. 2017 update

Pietro Boccaletto et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Monocytes and macrophages in abdominal aortic aneurysm

Juliette Raffort et al.

NATURE REVIEWS CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth

Anders Wanhainen et al.

ATHEROSCLEROSIS (2017)

Article Cardiac & Cardiovascular Systems

Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair

Julie Brittenden et al.

CIRCULATION (2017)

Review Cardiac & Cardiovascular Systems

Abdominal aortic aneurysm: novel mechanisms and therapies

Frank M. Davis et al.

CURRENT OPINION IN CARDIOLOGY (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data

Jun-Hao Li et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Biochemical Research Methods

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

Jeffrey T. Leek et al.

BIOINFORMATICS (2012)

Review Hematology

Mast Cells Important Players in the Orchestrated Pathogenesis of Abdominal Aortic Aneurysms

Jesper Swedenborg et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

Review Cardiac & Cardiovascular Systems

Current status of medical management for abdominal aortic aneurysm

Jonathan Golledge et al.

ATHEROSCLEROSIS (2011)

Review Immunology

Protective and pathogenic functions of macrophage subsets

Peter J. Murray et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Biochemical Research Methods

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

Matthew D. Wilkerson et al.

BIOINFORMATICS (2010)

Article Surgery

Whole Genome-expression Profiling Reveals a Role for Immune and Inflammatory Response in Abdominal Aortic Aneurysm Rupture

E. Choke et al.

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY (2009)

Article Cardiac & Cardiovascular Systems

Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm

Toshihiro Tsuruda et al.

CIRCULATION RESEARCH (2008)

Review Surgery

Potential circulating biomarkers for abdominal aortic aneurysm expansion and rupture - a systematic review

S. Urbonavicius et al.

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY (2008)