Network pharmacology- and molecular docking-based approaches to unveil the pharmacological mechanisms of dihydroartemisinin against esophageal carcinoma

Article Immunology

Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas

Lijie Chen et al.

Summary: This study provides a comprehensive analysis of the interplay between autophagy and ferroptosis in SCCs, and their synergistic roles in manipulating the immunological TME.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Oncology

Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC

Xing Niu et al.

Summary: Small cell lung cancer (SCLC) is an aggressive form of lung cancer with a poor prognosis. Although immune checkpoint inhibitors (ICIs) have been approved for the treatment of extensive-stage or relapsed SCLC, only a minority of patients respond to this therapy. The challenge for SCLC therapy is to transform the immune cold tumors into hot tumors that are more likely to respond to ICIs.

SEMINARS IN CANCER BIOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial

Zhihao Lu et al.

Summary: This study evaluated the efficacy of sintilimab in combination with chemotherapy for patients with unresectable locally advanced, recurrent, or metastatic oesophageal squamous cell carcinoma. The results demonstrated significant improvements in overall survival and progression free survival with sintilimab plus cisplatin and paclitaxel compared to placebo plus chemotherapy. Similar benefits were seen with sintilimab plus cisplatin and 5-fluorouracil.

BMJ-BRITISH MEDICAL JOURNAL (2022)

Add to Collection

Review Pharmacology & Pharmacy

Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy

Xu Zhang et al.

Summary: Esophageal cancer is a highly lethal disease with rapid progression and poor prognosis. The two major subtypes, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), have distinct risk factors and molecular characteristics. Although surgical and chemoradiotherapy approaches have been applied, molecularly targeted therapy for esophageal cancer is still in its early stages. Advances in large-scale next-generation sequencing have revealed genomic alterations in ESCC and EAC, providing insights into their roles in the development and progression of esophageal cancer. Potential therapeutic targets have been identified, and novel strategies are under development to combat this disease.

ACTA PHARMACEUTICA SINICA B (2022)

Add to Collection

Article Oncology

Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma

Ke Shi et al.

Summary: The study revealed that ubiquitin specific peptidase 3 (USP3) facilitates the expression of Aurora A in esophageal squamous cell carcinoma (ESCC) through deubiquitination, thereby promoting proliferation and invasion of ESCC cells.

BMC CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma

Mingxia Jiang et al.

Summary: The study demonstrates that Dihydroartemisinin (DHA) can induce pyroptosis in esophageal squamous cell carcinoma cells through the PKM2-caspase-8/3-GSDME pathway, inhibiting their growth. This finding holds significant implications for cancer therapy.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy

Ruijuan Du et al.

Summary: AURKA is overexpressed in cancers and regulates substrate functions through phosphorylation, participating in various classic oncogenic pathways.

MOLECULAR CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine

ShuangSang Fang et al.

Summary: Pharmacotranscriptomics has been used to evaluate drug efficacy and discover new drug targets. In the field of traditional Chinese medicine (TCM), there is a growing trend towards high-throughput transcriptomic screens for molecular effects of herbs/ingredients. HERB is a database that integrates gene targets for TCM herbs/ingredients and modern drugs, supporting the modernization of TCM and rational drug discovery efforts.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

UniProt: the universal protein knowledgebase in 2021

Alex Bateman et al.

Summary: The UniProt Knowledgebase aims to provide users with a comprehensive, high-quality set of protein sequences annotated with functional information. Updates over the past two years have increased the number of sequences to approximately 190 million, with new methods to assess proteome completeness and quality. UniProtKB has responded to the COVID-19 pandemic by expertly curating relevant entries and making them rapidly available through a dedicated portal.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels

Hamza Saidi et al.

Summary: DHA modulates calcium signaling and cell cycle progression in human T-cells by regulating TRPC3 and TRPC6 channels, resulting in inhibition of cell cycle progression and proliferation.

BIOCHIMIE (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

TNMplot.com: A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues

Aron Bartha et al.

Summary: This study established an integrated database of gene expression data from tumor and metastatic tissues, identifying potential therapeutic targets for different cancer types. The online platform allows real-time mining and analysis of the database, providing valuable insights for cancer research and treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Pharmacology & Pharmacy

Human Telomerase Reverse Transcriptase as a Therapeutic Target of Dihydroartemisinin for Esophageal Squamous Cancer

Qingrong Li et al.

Summary: hTERT is significantly upregulated in esophageal squamous cancer, promoting proliferation and migration of cancer cells. DHA inhibits proliferation and migration of esophageal cancer cells by down-regulating hTERT expression through the ROS/SP1 pathway.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Oncology

Molecular determinants of clinical outcomes with pembrolizumab versus paclitaxel in a randomized, open-label, phase III trial in patients with gastroesophageal adenocarcinoma

K. Shitara et al.

Summary: In a randomized setting, this analysis shows a strong association between tTMB and efficacy with pembrolizumab, but not with paclitaxel, in patients with gastric/GEJ adenocarcinoma. tTMB is suggested to be a significant and independent predictor beyond PD-L1 status.

ANNALS OF ONCOLOGY (2021)

Add to Collection

Article Oncology

Oxaliplatin/capecitabine or carboplatin/paclitaxel-based preoperative chemoradiation for resectable oesophageal adenocarcinoma (NeoSCOPE): Long-term results of a randomised controlled trial

Somnath Mukherjee et al.

Summary: This study evaluated two neoadjuvant chemoradiotherapy regimens for localised oesophageal adenocarcinoma or gastro-oesophageal junction adenocarcinoma, showing that CarPacRT had better survival outcomes and progression patterns compared to OxCapRT. Distant progression was more common than locoregional progression in both regimens, suggesting a need to prioritize systemic treatment optimization.

EUROPEAN JOURNAL OF CANCER (2021)

Add to Collection

Article Medicine, General & Internal

Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial

Huiyan Luo et al.

Summary: The addition of camrelizumab to chemotherapy significantly improved overall survival and progression-free survival in patients with advanced or metastatic esophageal squamous cell carcinoma. This treatment strategy could enhance the overall survival rate of patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Oncology

Perioperative or postoperative adjuvant oxaliplatin with S-1 versus adjuvant oxaliplatin with capecitabine in patients with locally advanced gastric or gastro-oesophageal junction adenocarcinoma undergoing D2 gastrectomy (RESOLVE): an open-label, superiority and non-inferiority, phase 3 randomised controlled trial

Xiaotian Zhang et al.

Summary: The study found that perioperative SOX treatment was more effective than adjuvant CapOx treatment in patients with locally advanced gastric cancer; adjuvant SOX treatment was non-inferior to adjuvant CapOx treatment in these patients, with similar safety profiles.

LANCET ONCOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

MicroRNA-1-3p Suppresses Malignant Phenotypes of Ameloblastoma Through Down-Regulating Lysosomal Associated Membrane Protein 2-Mediated Autophagy

Xing Niu et al.

Summary: The study found dysregulated autophagy in ameloblastoma (AB), with low expression of Beclin1 and high expression of LC3II/I and LAMP2. MiR-1-3p was downregulated in AB and negatively correlated with LAMP2 expression. Upregulation of miR-1-3p decreased LAMP2 expression and inhibited the proliferation, migration, and invasion of AM-1 cells, which could potentially serve as a target for AB therapy.

FRONTIERS IN MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

PubChem in 2021: new data content and improved web interfaces

Sunghwan Kim et al.

Summary: PubChem, a popular chemical information resource, has made substantial improvements in the past two years by adding data from over 100 new sources, updating its homepage and record pages, introducing new services like the Periodic Table and Pathway pages, and creating a special data collection related to COVID-19 and SARS-CoV-2 in response to the pandemic.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Article Integrative & Complementary Medicine