Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 10, Issue 5, Pages 1283-1288Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01947g
Keywords
-
Categories
Ask authors/readers for more resources
An environmentally friendly electrochemical fluorotrifluoromethylation of styrenes was developed, which involves tandem processes of electro-oxidation and radical and nucleophilic addition. Using commercial CF3SO2Na and Et3N•3HF as the sources of CF3 and F, a range of potentially bio-active multi-site F-containing compounds were obtained in moderate to good yields. This catalyst- and oxidant-free fluorotrifluoromethylation strategy offers mild conditions and high step economy features, and the reaction mechanism was investigated using several analytical methods.
An environmentally friendly electrochemical fluorotrifluoromethylation of styrenes was developed via the tandem processes of electro-oxidation and radical and nucleophilic addition. By using commercial CF3SO2Na and Et3N center dot 3HF as the CF3 and F sources, respectively, a series of potentially bio-active multi-site F-containing compounds were obtained in moderate to good yields. This fluorotrifluoromethylation strategy is catalyst- and oxidant-free, and demonstrates mild conditions and high step economy features. In addition, several analytical methods, including cyclic voltammetry and control experiments, were conducted to investigate a reasonable reaction mechanism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available