Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma

BACKGROUND: Asthma is a disease that can be separated into different phenotypes and endotypes based on the clinical characteristics and the molecular mechanisms of the condition, respectively. OBJECTIVE: To assess the association between blood eosinophil and neutrophil counts with clinical and molecular features in patients with adult-onset asthma. METHODS: Blood eosinophil and neutrophil counts were measured from 203 patients who took part in the Seinajoki Adult Asthma Study and attended the 12-year follow-up visit. The patients were then divided into four groups (pauci-granulocytic [n = 108], neutrophilic [n = 60], eosinophilic [n = 21], and mixed granulocytic [n = 14]), according to eosinophil and neutrophil levels. The cutoff values used to define

Automated summary

This study aims to assess the association between blood eosinophil and neutrophil counts and clinical and molecular features in patients with adult-onset asthma. The findings showed that patients can be divided into four groups (pauci-granulocytic, neutrophilic, eosinophilic, and mixed granulocytic) based on their eosinophil and neutrophil levels.