Related references
Note: Only part of the references are listed.
Review
Allergy
Bryan Oronsky et al.
Summary: Persistent post-COVID syndrome, a pathologic entity, involves persistent physical, medical, and cognitive sequelae following COVID-19. The syndrome includes immunosuppression and organ fibrosis, and its potential long-term effects place a burden on healthcare systems, patients' families, and society.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Respiratory System
Kiho Son et al.
Summary: This study investigated the presence of autoimmunity in COVID-19 patients up to a year after infection and its association with the development of post-acute sequalae of COVID-19 (PASC) symptoms. The results showed that COVID-19 patients had a higher rate of detectable ANAs compared to healthy controls and other respiratory infection patients at 3 months post-recovery. Specific antibodies were found to be associated with persistent symptoms such as fatigue and dyspnea. Further research is needed to understand the role of autoimmunity in PASC.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Medicine, General & Internal
Daniel Munblit et al.
Summary: Long-term symptoms of COVID-19 may become a significant global health burden, and there is a need to optimize and standardize the definition, diagnosis, and measurement of relevant outcomes.
Article
Biochemistry & Molecular Biology
Yapeng Su et al.
Summary: Post-acute sequelae of COVID-19 (PASC) is an emerging global crisis, and the quantifiable risk factors and biological associations are not well understood. In this study, a deep multi-omic investigation was conducted on 309 COVID-19 patients, and four PASC-anticipating risk factors were identified at the time of initial diagnosis. The study also observed changes in immune states during recovery from COVID-19.
Letter
Cell Biology
Martin Zickler et al.
Article
Endocrinology & Metabolism
Daniela Frasca et al.
Summary: This study aims to evaluate the impact of obesity on the quality of antibodies in COVID-19 patients. The presence of neutralizing and autoimmune antibodies in obese patients differs significantly from lean patients.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Review
Infectious Diseases
Joan B. Soriano et al.
Summary: People with COVID-19 might experience long-term symptoms known as long COVID or long-haul COVID. The lack of a standardized definition hinders the understanding and treatment of this condition. In a WHO-led Delphi process, a consensus definition was developed, stating that post-COVID-19 condition occurs in individuals with a history of SARS-CoV-2 infection, with symptoms lasting for at least 2 months and impacting everyday functioning. This common framework provides a foundation for future studies and therapy.
LANCET INFECTIOUS DISEASES
(2022)
Article
Immunology
Chansavath Phetsouphanh et al.
Summary: Phetsouphanh and colleagues found that individuals with long COVID exhibit persistent activation of the immune system even 8 months after infection. They also identified a set of analytes associated with long COVID, suggesting potential opportunities for prevention and treatment.
Review
Immunology
Saurabh Mehandru et al.
Summary: This review examines the underlying pathophysiological mechanisms of post-COVID-19 syndromes, including persistent inflammation, induced autoimmunity, and putative viral reservoirs. The disease is called 'long-haul COVID' or 'post-COVID-19 syndrome', and clinical symptoms include fatigue, dyspnea, and neuropsychiatric syndromes.
Article
Immunology
Jessica Seessle et al.
Summary: Long COVID, defined as persistent symptoms after SARS-CoV-2 infection, can last for at least 1 year and significantly impact life quality. Neurocognitive symptoms, possibly related to autoimmunity indicated by elevated ANA titers, are more common in females and can persist even when SARS-CoV-2 antibody levels are not significantly different from patients without symptoms.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
D. Castanares-Zapatero et al.
Summary: After almost 2 years of fighting against the SARS-CoV-2 pandemic, the number of patients experiencing persistent symptoms long after acute infection is concerning. This condition, known as long COVID or Post COVID-19 condition, has an unclear underlying pathophysiology. A comprehensive review was conducted to explore potential mechanisms for the persisting symptoms, such as organ damage, autonomic nervous system damage, immune dysregulation, auto-immunity, endothelial dysfunction, occult viral persistence, and coagulation activation.
ANNALS OF MEDICINE
(2022)
Review
Immunology
Felicia Ceban et al.
Summary: Post-COVID-19 syndrome, characterized by persistent symptoms after resolution of acute infection, is associated with significant fatigue and cognitive impairment. This study aimed to quantify the proportion of individuals experiencing fatigue and cognitive impairment 12 or more weeks after COVID-19 diagnosis, and to explore the inflammatory and functional consequences of post-COVID-19 syndrome. The results showed that a significant proportion of individuals continue to experience fatigue and cognitive impairment even after 12 or more weeks of COVID-19 diagnosis. Additionally, some individuals showed elevated levels of inflammatory markers and significant functional impairment.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Environmental Sciences
Yirui Ma et al.
Summary: This study aimed to review the available data on the long-term consequences of COVID-19 at 6 months and beyond. The findings suggest that there is a significant long-term impact on health and quality of life due to COVID-19.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Immunology
Yuanfeng Zhu et al.
Summary: Infection with SARS-CoV-2 causes respiratory problems and multi-organ dysfunction. One of the crucial mechanisms of COVID-19 immunopathology is the activation of neutrophils and the release of harmful neutrophil extracellular traps (NETs). Excessive NET generation has been observed in many COVID-19 patients, leading to unfavorable clotting disorders and immunothrombosis. Furthermore, excessive NETosis and NET generation are now recognized as mediators of additional pathophysiological abnormalities following SARS-CoV-2 infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Infectious Diseases
Tianqi Yang et al.
Summary: This review and meta-analysis found that previously hospitalized COVID-19 patients can experience a wide range of sequelae, with some symptoms persisting up to 1 year. Fatigue and somnipathy were the most commonly reported sequelae, while COVID-19 patients from Asia had a lower prevalence of symptoms compared to other regions.
Article
Nursing
Yong Huang et al.
Summary: This study retrospectively analyzed electronic health records from the University of California and found that the prevalence of post-acute sequelae of SARS-CoV-2 (PASC) was 11%. Five symptom clusters associated with PASC were identified. Women were more likely than men to develop PASC, with this pattern observed across different age groups and ethnicities.
CLINICAL NURSING RESEARCH
(2022)
Article
Multidisciplinary Sciences
Melissa D. Pinto et al.
Summary: This study aimed to identify distinct and significant patterns of symptoms in PASC survivors and provide strategies for early symptom management.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Christoph Schultheiss et al.
Summary: Post-acute sequelae of COVID-19 (PASC) is a global problem with unknown molecular drivers. A study found that 67.8% of participants, mostly with mild infections, reported PASC, with symptoms including fatigue, dyspnea, and concentration deficit. These symptoms persisted in 60% of participants over an average 8-month follow-up period. PASC was associated with elevated plasma levels of IL-18, IL-6, and TNF.
CELL REPORTS MEDICINE
(2022)
Article
Nursing
Kristine Anne Scordo et al.
Summary: As COVID-19 continues to spread, health care workers are seeing patients, known as long-haulers, who have not fully recovered from the illness after weeks or months, experiencing persistent chronic inflammation, organ damage sequelae, and hospitalization and social isolation effects. Healthcare providers play a crucial role in identifying and managing post-COVID-19 complications.
AACN ADVANCED CRITICAL CARE
(2021)
Article
Immunology
Michael J. Peluso et al.
Summary: This study found that persistent immune activation may be associated with ongoing symptoms following COVID-19, with cytokine levels during early recovery period being related to the development of PASC. This suggests potential therapeutic targets for those experiencing PASC.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Maria Dolores Folgueira et al.
Summary: This study compared the infectivity of SARS-CoV-2 in respiratory samples from patients with mild COVID-19 and those with severe bilateral pneumonia. Results showed that severe patients might shed viable virus for up to 4 weeks after symptom onset, even with high cycle threshold values and high neutralizing antibody titres.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Virology
Indre Kucinskaite-Kodze et al.
Summary: The study found that detectable levels of SARS-CoV-2-specific antibodies persist up to 13 months after infection for the majority of the cases. After 6 months, 95% of previously infected individuals had virus-specific antibodies, with a third still showing IgM indicating persistence. 83% of recovered individuals were seropositive 13 months after the outbreak, with one case of confirmed asymptomatic reinfection.
Letter
Oncology
Jiram Torres-Ruiz et al.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Eric Y. Wang et al.
Summary: COVID-19 patients show increased autoantibody reactivities against immunomodulatory proteins, which may affect immune function and lead to different clinical outcomes.
Review
Biochemistry & Molecular Biology
Ani Nalbandian et al.
Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.
Article
Infectious Diseases
Maddalena Peghin et al.
Summary: The study found a high prevalence rate of post-COVID-19 syndrome at 40.2% six months after onset, with factors associated including the presence of IgG antibodies, female gender, an increase in symptom number at onset, and ICU admission. Prospective follow-up for COVID-19 patients is recommended to identify long-term sequelae early.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Jiram Torres-Ruiz et al.
Summary: This study revealed novel immunological and metabolomic features associated with the severity and prognosis of COVID-19. Our models encompass the interplay among innate and adaptive immunity, inflammation-induced muscle atrophy, and hypoxia as the main drivers of COVID-19 severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Leonard A. Jason et al.
Summary: Symptoms among long-hauler COVID-19 patients tend to decrease over time, with an intensification of neurocognitive symptoms, while compared to ME/CFS, COVID-19 long-haulers initially have more severe symptoms in immune and orthostatic domains but show less severe symptoms over time, except in the orthostatic domain.
FATIGUE-BIOMEDICINE HEALTH AND BEHAVIOR
(2021)
Article
Medicine, General & Internal
Liu Wei et al.
CHINESE MEDICAL JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Jonas Schulte-Schrepping et al.
Review
Virology
Maria Smith et al.
JOURNAL OF VIROLOGY
(2020)
Article
Multidisciplinary Sciences
Sara De Biasi et al.
NATURE COMMUNICATIONS
(2020)
Article
Medicine, General & Internal
Amir H. Zamanipoor Najafabadi et al.
Article
Multidisciplinary Sciences
Jose G. Montoya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemistry & Molecular Biology
Christian Lood et al.
Review
Immunology
Marius Strioga et al.
Article
Health Care Sciences & Services
Dankmar Boehning et al.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2011)
Article
Immunology
Yannick Le Priol et al.
JOURNAL OF IMMUNOLOGY
(2006)
Article
Pathology
YJ Sui et al.
AMERICAN JOURNAL OF PATHOLOGY
(2004)
