☆ 4.8 Article

Comprehensive analysis of a glycolysis and cholesterol synthesis-related genes signature for predicting prognosis and immune landscape in osteosarcoma

FRONTIERS IN IMMUNOLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

TRAM2 promotes the malignant progression of glioma through PI3K/AKT/mTOR pathway

Xiang Gao et al.

Summary: Molecular biomarker TRAM2 is overexpressed in glioma and associated with malignancy properties and poorer survival. Silencing of TRAM2 inhibits glioma cell proliferation, invasion, migration, and EMT. TRAM2 is positively associated with the activation of the PI3K/AKT/mTOR signaling pathway.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

LncRNA HCG18 promotes osteosarcoma growth by enhanced aerobic glycolysis via the miR-365a-3p/PGK1 axis

Xiaohui Pan et al.

Summary: The increased expression of long noncoding RNA HCG18 in osteosarcoma promotes cell proliferation by regulating the miR-365a-3p/PGK1 axis, enhancing aerobic glycolysis.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

Add to Collection

Article Medical Laboratory Technology

MCAM is associated with metastasis and poor prognosis in osteosarcoma by modulating tumor cell migration

Xiaotian Du et al.

Summary: Our analysis identified MCAM as a potential novel prognostic biomarker for osteosarcoma, associated with increased cell migration ability and higher risk of metastasis, leading to poor prognoses in patients with OS.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

Add to Collection

Article Multidisciplinary Sciences

Construction and validation of a novel gene signature for predicting the prognosis of osteosarcoma

Jinpo Yang et al.

Summary: Using high-throughput sequencing technology, we have successfully generated a 17-gene signature that accurately predicts the prognosis of osteosarcoma. We have also identified potential immunotherapy targets associated with this signature and identified the important roles of CD8 T cells and activated mast cells in the predictive power of the gene signature.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

S100 calcium-binding protein A10 contributes to malignant traits in osteosarcoma cells by regulating glycolytic metabolism via the AKT/mTOR pathway

Feng Ling et al.

Summary: This study revealed that S100A10 is highly expressed in osteosarcoma tissues and cell lines. It promotes proliferation and metastasis while inhibiting apoptosis in osteosarcoma cells. S100A10 regulates the glycolysis process and activates the AKT/mTOR signaling pathway, thereby promoting malignant behavior in osteosarcoma cells.

BIOENGINEERED (2022)

Add to Collection

Article Immunology

HIF-1α Regulated WTAP Overexpression Promoting the Warburg Effect of Ovarian Cancer by m6A-Dependent Manner

Yuanyuan Lyu et al.

Summary: This study revealed that HIF-1α can upregulate the expression of WTAP under hypoxia, and high expression of WTAP predicts poor prognosis in OC patients. Knockdown of WTAP expression inhibits cell proliferation and invasive capacity in OC cells, while overexpression of WTAP enhances these abilities. WTAP interacts with DGCR8 to regulate the expression of miR-200 in an m6A-dependent manner, which subsequently affects the expression of HK2 and the Warburg effect in cells.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis

Yize Liu et al.

Summary: This study investigated a circular RNA called circROCK1-E3/E4 in osteosarcoma (OS) and found that it functions as a tumor suppressor by upregulating PTEN. The downregulation of circROCK1-E3/E4 is correlated with poor prognosis, suggesting its potential as a therapeutic target for OS.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

System analysis of VEGFA in renal cell carcinoma: The expression, prognosis, gene regulation network and regulation targets

Yongli Situ et al.

Summary: The study revealed that VEGFA expression is upregulated in patients with KIRC and KICH, while downregulated in KIRP. VEGFA expression significantly correlated with pathological stages in KIRC and KIRP, and patients with low VEGFA expression in KICH and KIRP had longer survival.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2022)

Add to Collection

Review Oncology

Immunomodulation by targeted anticancer agents

Giulia Petroni et al.

Summary: Targeted anticancer agents are designed to inhibit specific molecular alterations that support oncogenesis or tumor progression, but they may also have immunomodulatory effects that can influence therapeutic efficacy. Harnessing these effects could potentially lead to superior clinical outcomes.

CANCER CELL (2021)

Add to Collection

Article Medicine, Research & Experimental

Altered gene expression in glycolysis-cholesterol synthesis axis correlates with outcome of triple-negative breast cancer

Peng-Cheng Zhong et al.

Summary: Identification of molecular subtypes of TNBC based on metabolic characteristics revealed four subtypes, with the cholesterogenic type having the shortest median survival and the glycolytic type associated with longer survival. The expressions of cholesterogenic genes were correlated with specific genetic alterations, while classification of glycolytic and cholesterogenic pathways may improve personalized treatments for TNBC.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

Add to Collection

Article Oncology

MiR-205-5p suppresses angiogenesis in gastric cancer by downregulating the expression of VEGFA and FGF1

Junling Zhang et al.

Summary: miR-205-5p suppresses angiogenesis in gastric cancer by attenuating the expression of VEGFA and FGF1, suggesting that its upregulation may serve as a potential anti-angiogenic therapy for gastric cancer.

EXPERIMENTAL CELL RESEARCH (2021)

Add to Collection

Article Cell Biology

Cross-Talk of Focal Adhesion-Related Gene Defines Prognosis and the Immune Microenvironment in Gastric Cancer

Deli Mao et al.

Summary: This study systematically analyzed the role of focal adhesion-related genes in gastric cancer and found that mutations in these genes can affect patients' survival time and clinical characteristics. The research also indicated that the focal adhesion index is associated with the immune microenvironment, M2 macrophage infiltration, and GC subtypes, providing important insights for prognostic evaluation of gastric cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Oncology

The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer

Jing-Zi Wang et al.

Summary: This study demonstrated that ALYREF stabilizes PKM2 mRNA and binds to its m5C sites in bladder cancer, promoting cell proliferation. High expressions of PKM2 and ALYREF predict poor prognosis in bladder cancer patients. Additionally, HIF-1alpha indirectly upregulates PKM2 expression by activating ALYREF, suggesting a promising therapeutic target for bladder cancer.

CANCER COMMUNICATIONS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

Identification of potential gene signatures associated with osteosarcoma by integrated bioinformatics analysis

Yutao Jia et al.

Summary: This study identified novel potential gene signatures associated with osteosarcoma and revealed key genes in the transcription factor-gene network that could serve as diagnostic and potential therapeutic targets for osteosarcoma.ROC analysis of two published datasets further confirmed the diagnostic values of certain key genes for osteosarcoma patients.

PEERJ (2021)

Add to Collection

Article Cell Biology

A Novel Six Metastasis-Related Prognostic Gene Signature for Patients With Osteosarcoma

Di Zheng et al.

Summary: The study identified 6 metastasis-related genes and constructed a novel prognostic signature for predicting overall survival in osteosarcoma patients, with FHIT potentially being a therapeutic target.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice

Hongxia Duan et al.

Summary: CD146 plays a crucial role in activating LCK in the TCR signaling network, promoting T cell development and antitumor response. This finding highlights the potential of CD146-based intervention in tumor immunotherapy.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Identification and validation of seven RNA binding protein genes as a prognostic signature in oral cavity squamous cell carcinoma

Zijing Huang et al.

Summary: This study identified 7 prognosis-related RNA binding proteins in OCSCC, which can be used to predict clinical prognosis and identify potential therapeutic targets.

BIOENGINEERED (2021)

Add to Collection

Article Genetics & Heredity

Identification of subgroups along the glycolysis-cholesterol synthesis axis and the development of an associated prognostic risk model

Enchong Zhang et al.

Summary: Subtyping skin cutaneous melanoma (SKCM) patients based on glycolytic and cholesterogenic genes is effective, with glycolytic subtype patients showing the worst prognosis. A predictive model was developed to enhance clinical decisions, and potential drugs for high-risk SKCM patients were also identified.

HUMAN GENOMICS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

Li Li et al.

Summary: YAP, a transcription co-factor, binds to thousands of enhancer loci to stimulate tumor aggressiveness. Through unbiased functional approaches, researchers identified and characterized TRAM2 as a novel mediator of cellular proliferation, migration, and invasion induced by YAP. These findings help elucidate the mechanisms by which YAP promotes cancer aggressiveness and may aid in cancer metastasis diagnosis.

GENOME BIOLOGY (2021)

Add to Collection

Article Oncology

Altered Gene Expression along the Glycolysis-Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer

Joanna M. Karasinska et al.

CLINICAL CANCER RESEARCH (2020)

Add to Collection

Article Medicine, Research & Experimental

Comprehensive analysis of the association between tumor glycolysis and immune/inflammation function in breast cancer

Wenhui Li et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Add to Collection

Review Cell Biology

Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

Jozsef Dudas et al.

CELLS (2020)

Add to Collection

Article Medicine, Research & Experimental

Identification and Validation of a Potent Multi-miRNA Signature for Prediction of Prognosis of Osteosarcoma Patients

Xinle Luo et al.

MEDICAL SCIENCE MONITOR (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Cholesterol metabolism: New functions and therapeutic approaches in cancer

Huanji Xu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Add to Collection

Editorial Material Immunology

Editorial: NKT Cells in Cancer Immunotherapy

Tonya J. Webb et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Oncology

The novel circ_0028171/miR-218-5p/IKBKB axis promotes osteosarcoma cancer progression

Feng Pan et al.

CANCER CELL INTERNATIONAL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7

Jie Chen et al.

ONCOGENE (2020)

Add to Collection

Article Cell Biology

A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer

Ye Du et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Article Oncology

A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma

Jason A. Somarelli et al.

CANCERS (2020)

Add to Collection

Article Genetics & Heredity

LncRNA PPP1R14B-AS1 Promotes Tumor Cell Proliferation and Migration via the Enhancement of Mitochondrial Respiration

Yibin Yang et al.

FRONTIERS IN GENETICS (2020)

Add to Collection

Review Oncology

Role of de novo cholesterol synthesis enzymes in cancer

Jie Yang et al.

JOURNAL OF CANCER (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance

Jiajie Wei et al.

MOLECULAR CELL (2019)

Add to Collection

Article Multidisciplinary Sciences

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

Demin Cai et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Review Oncology

Squalene epoxidase as a promising metabolic target in cancer treatment

Gabriella Cirmena et al.

CANCER LETTERS (2018)

Add to Collection

Article Cell Biology

Statins enhance efficacy of venetoclax in blood cancers

J. Scott Lee et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Add to Collection

Article Cell Biology

Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo

Kangmao Huang et al.

CELL DEATH & DISEASE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC)

Yifan Kong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Add to Collection

Article Multidisciplinary Sciences

A transfer-RNA-derived small RNA regulates ribosome biogenesis

Hak Kyun Kim et al.

NATURE (2017)

Add to Collection

Review Oncology

Anti-angiogenesis target therapy for advanced osteosarcoma

Lu Xie et al.

ONCOLOGY REPORTS (2017)

Add to Collection

Article Oncology

Stromal regulation of prostate cancer cell growth by mevalonate pathway enzymes HMGCS1 and HMGCR

Shingo Ashida et al.

ONCOLOGY LETTERS (2017)

Add to Collection

Article Gastroenterology & Hepatology

Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy

Giuseppe Di Caro et al.

GUT (2016)

Add to Collection

Article Oncology

MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding

I. Made Winarsa Ruma et al.

CLINICAL & EXPERIMENTAL METASTASIS (2016)

Add to Collection

Article Genetics & Heredity

HMGCR positively regulated the growth and migration of glioblastoma cells

Zhihua Qiu et al.

GENE (2016)

Add to Collection

Article Multidisciplinary Sciences

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

Wei Yang et al.

NATURE (2016)

Add to Collection

Article Multidisciplinary Sciences

Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer

David N. Brown et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Review Oncology

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

Luana Schito et al.

TRENDS IN CANCER (2016)

Add to Collection

Review Oncology

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

Jianrong Lu et al.

CANCER LETTERS (2015)

Add to Collection

Article Cell Biology

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

Shuhua Yue et al.

CELL METABOLISM (2014)

Add to Collection

Article Oncology

MCAM expression is associated with poor prognosis in non-small cell lung cancer

X. Zhang et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2014)

Add to Collection

Review Medicine, General & Internal

VEGFA and tumour angiogenesis

L. Claesson-Welsh et al.

JOURNAL OF INTERNAL MEDICINE (2013)

Add to Collection

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

Add to Collection

Article Oncology

A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer

Christina Yau et al.

BREAST CANCER RESEARCH (2010)

Add to Collection

Article Biochemistry & Molecular Biology

The role of human ribosomal proteins in the maturation of rRNA and ribosome production

Sara Robledo et al.

RNA (2008)

Add to Collection

Article Oncology

High macrophage infiltration along the tumor front correlates with improved survival in colon cancer

Johan Forssell et al.

CLINICAL CANCER RESEARCH (2007)

Add to Collection

Article Biochemistry & Molecular Biology

TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis

B Stefanovic et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.