4.8 Review

IgY antibodies: The promising potential to overcome antibiotic resistance

Related references

Note: Only part of the references are listed.
Article Instruments & Instrumentation

Intranasal drug delivery: opportunities and toxicologic challenges during drug development

Lea-Adriana Keller et al.

Summary: In the last decade, there has been a growing interest in intranasal drug delivery in pharmaceutical R&D. This review article highlights the advantages of nasal delivery for local and systemic drug delivery, as well as for CNS indications, compared to conventional systemic approaches. However, formulation limitations and toxicological considerations remain areas that need further optimization in this field.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Article Biotechnology & Applied Microbiology

Polyclonal hen egg yolk antibodies could confer passive protection against Salmonella serotypes in broiler chicks

Nagappa Karabasanavar et al.

Summary: This study found that prophylactic feeding of egg yolk containing polyclonal IgY can provide passive protection for chicks and reduce caecal Salmonella carriage.

JOURNAL OF FOOD SAFETY (2022)

Article Agriculture, Dairy & Animal Science

Scientometric analysis and perspective of IgY technology study

Rao Wu et al.

Summary: Egg yolk immunoglobulin (IgY) is an antibody produced in birds against pathogens, which has various applications in human and veterinary medicine. Scientometric analysis of IgY-related publications revealed an increasing trend in research articles, with China, the United States, and Canada being the leading contributors. The results of this analysis can facilitate the commercialization and industrialization of IgY technology.

POULTRY SCIENCE (2022)

Article Biochemistry & Molecular Biology

Synergistic activity between beta-lactams and igy antibodies against Pseudomonas aeruginosa in vitro

Renata Fernandes Sanches et al.

Summary: The study assessed the synergistic action between anti-P. aeruginosa IgY and beta-lactam antibiotics ceftazidime, imipenem, and meropenem. The results showed that IgY antibodies exhibited antimicrobial activity against P. aeruginosa and had a synergistic effect when combined with the antibiotics tested.

MOLECULAR IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

Specific egg yolk antibody raised to biofilm associated protein (Bap) is protective against murine pneumonia caused by Acinetobacter baumannii

Azam Ranjbar et al.

Summary: The prophylactic potential of egg yolk immunoglobulin (IgY) against Acinetobacter baumannii was evaluated and proved effective in a murine pneumonia model.

SCIENTIFIC REPORTS (2022)

Article Microbiology

SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected mice

Sherif A. El-Kafrawy et al.

Summary: The use of IgY antibodies from chickens has shown prophylactic efficacy against SARS-CoV-2 in mice, reducing viral replication, morbidity, and lung pathology.

PLOS PATHOGENS (2022)

Article Microbiology

Chicken IgY reduces the risk of Pseudomonas aeruginosa urinary tract infections in a murine model

Franziska A. Schwartz et al.

Summary: Passive intravesical administration of avian egg yolk anti-Pseudomonas antibodies (IgY) may be a novel strategy to prevent urinary tract infections with Pseudomonas aeruginosa.

FRONTIERS IN MICROBIOLOGY (2022)

Review Immunology

Trends in industrialization and commercialization of IgY technology

Saeed Yakhkeshi et al.

Summary: IgY technology involves a cost-effective production process of generating avian immunoglobulin for various applications in human and veterinary medicine. Recent progress in this field includes an increase in patent applications and clinical trials. Prospective analysis of the commercialization potential of IgY-based products is crucial.

FRONTIERS IN IMMUNOLOGY (2022)

Article Immunology

Feasibility of avian antibodies as prophylaxis against enterotoxigenic escherichia coli colonization

Kyle Brumfield et al.

Summary: This research evaluates the feasibility of using avian immunoglobulins (IgY) to prevent diarrheal illness caused by enterotoxigenic Escherichia coli (ETEC). The results show that IgY can inhibit the adhesion of ETEC and has the potential to be a prophylactic treatment for diarrheal diseases.

FRONTIERS IN IMMUNOLOGY (2022)

Review Immunology

Antibody-Based Immunotherapies as a Tool for Tackling Multidrug-Resistant Bacterial Infections

Antonio M. M. Seixas et al.

Summary: The increasing antimicrobial resistance worldwide poses a significant threat to modern medicine, leading to infections that are untreatable by conventional therapies. Factors such as misuse and poor adherence by patients exacerbate the severity of this issue, highlighting the need for the development of more immunotherapies to replace antimicrobials.

VACCINES (2022)

Letter Biochemistry & Molecular Biology

Nasal delivery of thermostable and broadly neutralizing antibodies protects mice against SARS-CoV-2 infection

Wenhui Fan et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Chemistry, Medicinal

Immunotherapeutic Efficacy of IgY Antibodies Targeting the Full-Length Spike Protein in an Animal Model of Middle East Respiratory Syndrome Coronavirus Infection

Sherif A. El-Kafrawy et al.

Summary: In this study, chicken egg yolk antibodies specific to the MERS-CoV spike protein were developed and shown to efficiently neutralize MERS-CoV infection both in vitro and in vivo.

PHARMACEUTICALS (2021)

Article Infectious Diseases

Azithromycin potentiates avian IgY effect against Pseudomonas aeruginosa in a murine pulmonary infection model

Kim Thomsen et al.

Summary: The combination of azithromycin and anti-Pseudomonas IgY therapy enhances bacterial killing and pulmonary elimination of P. aeruginosa, leading to a decrease in inflammatory markers and potential clinical application for improving anti-Pseudomonas strategies.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

Article Multidisciplinary Sciences

Specific egg yolk immunoglobulin as a promising non-antibiotic biotherapeutic product against Acinetobacter baumannii pneumonia infection

Abolfazl Jahangiri et al.

Summary: In a murine pneumonia model, specific IgYs against OmpA, Omp34, and IWC of A. baumannii showed therapeutic effects, with IgYs raised against OmpA and IWC providing the highest protection, followed by those against Omp34. The combination of rOmpA and rOmp34 IgYs demonstrated the lowest protection.

SCIENTIFIC REPORTS (2021)

Review Agriculture, Multidisciplinary

Potential Therapeutic Effects of Egg Yolk Antibody (IgY) in Helicobacter pylori Infections.A Review

Leheng Zhang et al.

Summary: H. pylori infection affects half of the global population, and traditional therapies face challenges, necessitating new treatment approaches. IgY from chicken egg yolk is gaining attention as an alternative therapy for H. pylori infection.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Gastroenterology & Hepatology

Dietary multivalent anti-Helicobacter pylori immunoglobulin Y significantly increase the H. pylori eradication and improve the clinical symptoms in patients

Rong Guo et al.

Summary: The study developed a multivalent anti-H. pylori immunoglobulin Y through expressing and purifying recombinant antigens, demonstrating its inhibitory effect on H. pylori in vitro and a certain therapeutic efficacy in clinical trials.

HELICOBACTER (2021)

Article Biochemistry & Molecular Biology

In vivo neutralization of bee venom lethality by IgY antibodies

Carlos Leonidas Leiva et al.

Summary: A novel composition containing specific IgY antibodies was developed to recognize key components of bee venom, demonstrating the potential for treating envenoming accidents caused by multiple bee stings.

MOLECULAR IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Anti-flagellin IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound murine models in a non-type-specific mode

Tooba Sadat Ahmadi et al.

Summary: The study evaluated the antibacterial potency of IgY antibodies raised against Pseudomonas aeruginosa flagellin, confirming their role in reducing bacterial motility, biofilm formation, and invasion ability, as well as providing high protective efficacy through polymorphonuclear leukocyte-enhanced bacterial killing. The protective efficacy of anti-flagellin IgY antibodies was demonstrated in animal models, highlighting their potential as a novel therapeutic option against PA infection.

MOLECULAR IMMUNOLOGY (2021)

Review Immunology

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

Lucia Lee et al.

Summary: Chicken immunoglobulin Y (IgY) is a highly conserved homolog of human immunoglobulin G (IgG) that has shown benefits and a favorable safety profile in animal models of human infectious diseases. IgY is fast-acting, easy to produce, and low cost, making it a promising tool for the detection, prevention, and treatment of human and animal infections.

FRONTIERS IN IMMUNOLOGY (2021)

Article Pharmacology & Pharmacy

Near Infrared Photo-Antimicrobial Targeting Therapy for Candida albicans

Hirotoshi Yasui et al.

Summary: The newly developed treatment method for drug-resistant microorganisms, IgY-PAT(2), utilizes near-infrared photoimmunotherapy, enhancing the antimicrobial effects by conjugating IR700, and shows promising therapeutic effects in a mouse model.

ADVANCED THERAPEUTICS (2021)

Review Immunology

IgY-technology (egg yolk antibodies) in human medicine: A review of patents and clinical trials

Carlos Leonidas Leiva et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Article Biotechnology & Applied Microbiology

Application of IgY antibodies against staphylococcal protein A (SpA) of Staphylococcus aureus for detection and prophylactic functions

Rohini Krishna Kota et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

IgY Targeting Bacterial Quorum-Sensing Molecules in Implant-Associated Infections

Ulrike Dapunt et al.

MOLECULES (2020)

Article Public, Environmental & Occupational Health

Antimicrobial stewardship: Staff nurse knowledge and attitudes

Katreena Merrill et al.

AMERICAN JOURNAL OF INFECTION CONTROL (2019)

Review Biochemistry & Molecular Biology

Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance

Chandradhish Ghosh et al.

TRENDS IN MICROBIOLOGY (2019)

Review Immunology

Egg yolk antibodies (IgY) and their applications in human and veterinary health: A review

E. P. V. Pereira et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Article Infectious Diseases

Role of MIC levels of resistance to clarithromycin and metronidazole in Helicobacter pylori eradication

Vincenzo De Francesco et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

Article Biotechnology & Applied Microbiology

Specific egg yolk antibodies (IgY) confer protection against Acinetobacter baumannii in a murine pneumonia model

A. Jahangiri et al.

JOURNAL OF APPLIED MICROBIOLOGY (2019)

Article Agriculture, Dairy & Animal Science

Deciphering desirable immune responses from disease models with resistant and susceptible chickens

Leon J. Broom et al.

POULTRY SCIENCE (2019)

Article Gastroenterology & Hepatology

Fifth Chinese National Consensus Report on the management of Helicobacter pylori infection

Wen Zhong Liu et al.

HELICOBACTER (2018)

Article Genetics & Heredity

Oncologic orphan drugs approved in the EU - do clinical trial data correspond with real-world effectiveness?

Yvonne Schuller et al.

ORPHANET JOURNAL OF RARE DISEASES (2018)

Review Infectious Diseases

Antibiotic resistance: a rundown of a global crisis

Bilal Aslam et al.

INFECTION AND DRUG RESISTANCE (2018)

Article Pharmacology & Pharmacy

Development of IgY antibodies against anti-snake toxins endowed with highly lethal neutralizing activity

David Gitirana da Rocha et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Article Biochemical Research Methods

Avian antibodies (IgY) against Trypanosoma cruzi: Purification and characterization studies

Thirssa H. Grando et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2017)

Review Biochemical Research Methods

Insights into the chicken IgY with emphasis on the generation and applications of chicken recombinant monoclonal antibodies

Warren Lee et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2017)

Review Food Science & Technology

Chicken Egg Yolk Antibodies (IgY) for Prophylaxis and Treatment of Rotavirus Diarrhea in Human and Animal Neonates: A Concise Review

Hlaing Myat Thu et al.

KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES (2017)

Article Medicine, Research & Experimental

Effects of specific egg yolk immunoglobulin on pan-drug-resistant Acinetobacter baumannii

Huaying Shi et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Microbiology

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

Sebastian M. Gygli et al.

FEMS MICROBIOLOGY REVIEWS (2017)

Article Medicine, Research & Experimental

Comparative transcriptomics analyses of the different growth states of multidrug-resistant Acinetobacter baumannii

Shuai Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Gastroenterology & Hepatology

Review article: the global emergence of Helicobacter pylori antibiotic resistance

I. Thung et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2016)

Article Immunology

EFFECT OF TOPICAL ANTI-STREPTOCOCCUS MUTANS IgY GEL ON QUANTITY OF S. MUTANS ON RATS' TOOTH SURFACE

Endang W. Bachtiar et al.

ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA (2016)

Article Respiratory System

Anti-Pseudomonas aeruginosa IgY antibodies augment bacterial clearance in a murine pneumonia model

K. Thomsen et al.

JOURNAL OF CYSTIC FIBROSIS (2016)

Article Immunology

Inhibitory effects of rHP-NAP IgY against Helicobacter pylori attachment to AGS cell line

Katayoun Borhani et al.

MICROBIAL PATHOGENESIS (2016)

Article Biotechnology & Applied Microbiology

Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

Kim Thomsen et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)

Article Multidisciplinary Sciences

Comprehensive N-Glycan Profiling of Avian Immunoglobulin Y

Sarah Gilgunn et al.

PLOS ONE (2016)

Article Medicine, General & Internal

Antibiotic resistance: what, why, where, when and how?

N. Sabtu et al.

BRITISH MEDICAL BULLETIN (2015)

Article Immunology

Evolving Resistance Among Gram-positive Pathogens

Jose M. Munita et al.

CLINICAL INFECTIOUS DISEASES (2015)

Article Veterinary Sciences

Egg yolk IgY antibodies: A therapeutic intervention against group A rotavirus in calves

C. Vega et al.

RESEARCH IN VETERINARY SCIENCE (2015)

Article Biology

Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment

Sibhghatulla Shaikh et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2015)

Article Immunology

The Future of Antibiotics and Resistance: A Tribute to a Career of Leadership by John Bartlett

Brad Spellberg et al.

CLINICAL INFECTIOUS DISEASES (2014)

Review Pharmacology & Pharmacy

Challenges and future prospects of antibiotic therapy: from peptides to phages utilization

Santi M. Mandal et al.

FRONTIERS IN PHARMACOLOGY (2014)

Article Biotechnology & Applied Microbiology

Molecular Analysis of the Acinetobacter baumannii Biofilm-Associated Protein

H. M. Sharon Goh et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)

Article Infectious Diseases

Antibiotic resistance-the need for global solutions

Ramanan Laxminarayan et al.

LANCET INFECTIOUS DISEASES (2013)

Article Biotechnology & Applied Microbiology

Oral passive IgY-based immunotherapeutics A novel solution for prevention and treatment of alimentary tract diseases

Shofiqur Rahman et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2013)

Review Microbiology

Insights into antibiotic resistance through metagenomic approaches

Robert Schmieder et al.

FUTURE MICROBIOLOGY (2012)

Article Infectious Diseases

Diabetic murine models for Acinetobacter baumannii infection

Guanpingsheng Luo et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)

Review Biochemistry & Molecular Biology

Progress on research of chicken IgY antibody-FcRY receptor combination and transfer

Zehua Tian et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2012)

Article Medicine, General & Internal

Clinical Outcomes of Tigecycline in the Treatment of Multidrug-Resistant Acinetobacter baumannii Infection

Jung Ar Shin et al.

YONSEI MEDICAL JOURNAL (2012)

Review Food Science & Technology

Egg Yolk Antibodies for Passive Immunity

Jennifer Kovacs-Nolan et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 3 (2012)

Article

Extraction, Isolation And Characterization Of Bioactive Compounds From Plants’ Extracts

S Sasidharan et al.

African Journal of Traditional Complementary and Alternative Medicines (2011)

Article Integrative & Complementary Medicine

Proteomic Analysis of Effects on Natural Herb Additive Containing Immunoglobulin Yolksac (IgY) in Pigs

Hyeon-Soo Park et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Application of chicken egg yolk immunoglobulins in the control of terrestrial and aquatic animal diseases: A review

Yongping Xu et al.

BIOTECHNOLOGY ADVANCES (2011)

Article Infectious Diseases

Acinetobacter baumannii isolates from pets and horses in Switzerland: molecular characterization and clinical data

Andrea Endimiani et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)

Article Microbiology

Synergy Testing by Etest, Microdilution Checkerboard, and Time-Kill Methods for Pan-Drug-Resistant Acinetobacter baumannii

Madhuri M. Sopirala et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Article Agriculture, Dairy & Animal Science

Chicken monoclonal IgY antibody: a novel antibody development strategy

Xiaoying Zhang et al.

AVIAN BIOLOGY RESEARCH (2010)

Review Microbiology

Horizontal gene transfer and the genomics of enterococcal antibiotic resistance

Kelli L. Palmer et al.

CURRENT OPINION IN MICROBIOLOGY (2010)

Article Health Care Sciences & Services

Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes

Elizabeth B. Hirsch et al.

EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH (2010)

Article Biotechnology & Applied Microbiology

Egg Yolk Antibodies for Detection and Neutralization of Clostridium botulinum Type A Neurotoxin

D. L. Trott et al.

JOURNAL OF FOOD PROTECTION (2009)

Article Biochemical Research Methods

Efficacy of Passive Immunization with IgY Antibodies to a 58-kDa H. pylori Antigen on Severe Gastritis in BALB/c Mouse Model

Abdelfattah M. Attallah et al.

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY (2009)

Review Medicine, General & Internal

Current concepts: Acinetobacter infection

L. Silvia Munoz-Price et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Veterinary Sciences

Cross-reactivity of anti-chicken IgY antibody with immunoglobulins of exotic avian species

Carolyn Cray et al.

VETERINARY CLINICAL PATHOLOGY (2008)

Review Gastroenterology & Hepatology

Eradication therapy for Helicobacter pylori

Nimish Vakil et al.

GASTROENTEROLOGY (2007)

Article Biochemistry & Molecular Biology

Humanization of chicken monoclonal antibody using phage-display system

N Nishibori et al.

MOLECULAR IMMUNOLOGY (2006)

Review Medicine, Research & Experimental

Chicken egg yolk antibodies (IgY-technology): A review of progress in production and use in research and human and veterinary medicine

K Schade et al.

ATLA-ALTERNATIVES TO LABORATORY ANIMALS (2005)

Review Microbiology

Pathogenic Escherichia coli

JB Kaper et al.

NATURE REVIEWS MICROBIOLOGY (2004)

Review Microbiology

Passive antibody therapy for infectious diseases

A Casadevall et al.

NATURE REVIEWS MICROBIOLOGY (2004)

Review Biochemistry & Molecular Biology

Molecular pathways to neurodegeneration

E Bossy-Wetzel et al.

NATURE MEDICINE (2004)

Article Gastroenterology & Hepatology

Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection

H Suzuki et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2004)

Article Dentistry, Oral Surgery & Medicine

The effects of egg-derived antibodies to glucosyltransferases on dental caries in rats

C Kruger et al.

CARIES RESEARCH (2004)

Review Immunology

Defensins: Antimicrobial peptides of innate immunity

T Ganz

NATURE REVIEWS IMMUNOLOGY (2003)

Article Oncology

Retention of specific yolk IgY in the human oral cavity

D Carlander et al.

BIODRUGS (2002)

Article Biochemical Research Methods

Methods for the generation of chicken monoclonal antibody fragments by phage display

J Andris-Widhopf et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2000)

Review Microbiology

Mutation frequencies and antibiotic resistance

JL Martinez et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)

Article Engineering, Biomedical

A comparative study between the adsorption of IgY and IgG on latex particles

L Davalos-Pantoja et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2000)