Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1054753
Keywords
neutrophil extracellular traps; liver transplantation; ischemia-reperfusion injury; acute rejection; thrombosis; hepatocellular carcinoma recurrence; therapeutic targets
Categories
Funding
- National Natural Science Foundation of China
- [81873592]
- [82170666]
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NETs play an important role in liver transplantation complications, including ischemia-reperfusion injury, acute rejection, thrombosis, and hepatocellular carcinoma recurrence. Therefore, NETs have the potential to be a target for liver transplantation therapy.
Many end-stage liver disease etiologies are attributed to robust inflammatory cell recruitment. Neutrophils play an important role in inflammatory infiltration and neutrophil phagocytosis, oxidative burst, and degranulation. It has also been suggested that neutrophils may release neutrophil extracellular traps (NETs) to kill pathogens. It has been proven that neutrophil infiltration within the liver contributes to an inflammatory microenvironment and immune cell activation. Growing evidence implies that NETs are involved in the progression of numerous complications of liver transplantation, including ischemia-reperfusion injury, acute rejection, thrombosis, and hepatocellular carcinoma recurrence. NETs are discussed in this comprehensive review, focusing on their effects on liver transplantation complications. Furthermore, we discuss NETs as potential targets for liver transplantation therapy.
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