Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1022228
Keywords
PD-1; PD-L1; idiopathic pulmonary fibrosis; profibrotic role; immunomodulatory role; therapeutic target
Categories
Funding
- Key Research and development program of Shaanxi Province
- National Natural Science Foundation of China
- Innovation Capability Program of Shaanxi
- [2020GXLH-Y020]
- [82141126]
- [2021TD-44]
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This review summarizes the role of the PD-1/PD-L1 axis in idiopathic pulmonary fibrosis (IPF). The PD-1/PD-L1 pathway plays a predominant profibrotic role in IPF by interacting with multiple cell types and pathways. Blocking the PD-1/PD-L1 pathway can attenuate the severity of pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with a bleak prognosis. Mounting evidence suggests that IPF shares bio-molecular similarities with lung cancer. Given the deep understanding of the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway in cancer immunity and the successful application of immune checkpoint inhibitors (ICIs) in lung cancer, recent studies have noticed the role of the PD-1/PD-L1 axis in IPF. However, the conclusions are ambiguous, and the latent mechanisms remain unclear. In this review, we will summarize the role of the PD-1/PD-L1 axis in IPF based on current murine models and clinical studies. We found that the PD-1/PD-L1 pathway plays a more predominant profibrotic role than its immunomodulatory role in IPF by interacting with multiple cell types and pathways. Most preclinical studies also indicated that blockade of the PD-1/PD-L1 pathway could attenuate the severity of pulmonary fibrosis in mice models. This review will bring significant insights into understanding the role of the PD-1/PD-L1 pathway in IPF and identifying new therapeutic targets.
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