4.8 Article

Desmosterol: A natural product derived from macroalgae modulates inflammatory response and oxidative stress pathways in intestinal epithelial cells

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Targeted inhibition of PPARα ameliorates CLA-induced hypercholesterolemia via hepatic cholesterol biosynthesis reprogramming

Hao-Yu Liu et al.

Summary: This study revealed that dietary conjugated linoleic acids (CLA) can induce hypercholesterolemia (HCL) and liver steatosis through multiple pathways, with PPAR alpha, ROR gamma, and SREBP2 being important players in the hepatic cholesterol biosynthesis programming. The small-molecule compound GW6471 was found to have a therapeutic effect for CLA-induced HCL by disrupting the physical association between PPAR alpha and SREBP2, thus affecting the expression of cholesterol biosynthesis genes.

LIVER INTERNATIONAL (2022)

Article Pharmacology & Pharmacy

Inhibiting DNA methylation alleviates cisplatin- induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1-PI3K/AKT pathway

Yingzi He et al.

Summary: This study aimed to assess the potential effect of the DNA methyltransferase (DNMT) inhibitor RG108 on cisplatin-induced ototoxicity. The results showed that RG108 can reduce cisplatin-induced damage in hair cells and spiral ganglion neurons by protecting mitochondrial function and reducing apoptosis and reactive oxygen species accumulation. RG108 treatment also triggered the PI3K/AKT pathway and regulated the expression of related genes. Therefore, RG108 might represent a new potential agent for preventing hearing loss induced by cisplatin.

ACTA PHARMACEUTICA SINICA B (2022)

Article Biochemistry & Molecular Biology

Lithocholic Acid Alleviates Deoxynivalenol-Induced Lethal Cholesterol Metabolic Abnormalities in IPI-2I Cells

Yanwei Li et al.

Summary: The study demonstrated that lithocholic acid (LCA) alleviated toxic apoptosis caused by Deoxynivalenol (DON) by regulating cholesterol metabolism and modulating the expression of key genes involved in cholesterol biosynthesis and transformation in DON-exposed cells.

METABOLITES (2022)

Article Biochemistry & Molecular Biology

M6A RNA Methylation Mediates NOD1/NF-kB Signaling Activation in the Liver of Piglets Challenged with Lipopolysaccharide

Menghui Xu et al.

Summary: This study found that lipopolysaccharide activates the NOD1/NF-κ B pathway through altering m(6)A RNA methylation, promoting the production of inflammatory cytokines and leading to liver inflammation and damage.

ANTIOXIDANTS (2022)

Article Biochemistry & Molecular Biology

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

Alexandra Schnell et al.

Summary: This study characterized the heterogeneity, plasticity, and migratory phenotypes of tissue Th17 cells in different states, revealing their roles in intestinal and central nervous system autoimmune inflammation. The research found that intestinal Th17 cells not only maintain tissue homeostasis but also directly contribute to the development of extra-intestinal autoimmune diseases.
Article Multidisciplinary Sciences

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis

Xinbo Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Cell Biology

Importance of the pig as a human biomedical model

Joan K. Lunney et al.

Summary: Pigs have significant potential as biomedical models for studying human developmental processes, congenital diseases, and pathogen response mechanisms, as well as serving as xenotransplant organ donors and tools for vaccine and drug design. The similarities between pigs and humans in anatomy, physiology, immunology, and genetics enhance their potential as human models. Therefore, utilizing animal models that closely resemble humans, such as pigs, is crucial for relevant and reproducible research.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Editorial Material Immunology

Editorial: Cytokines and Intestinal Mucosal Immunity

Theresa T. Pizarro et al.

FRONTIERS IN IMMUNOLOGY (2021)

Article Microbiology

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1

Wei Li et al.

Summary: Bile acids regulate immune balance by affecting T cell differentiation, with isoalloLCA promoting T-reg cell differentiation through chromatin structure changes; gut bacteria capable of producing isoalloLCA belong to common human gut bacterial phylum Bacteroidetes, and NR4A1 is essential for isoalloLCA's effects on T-reg cells; significantly reduced levels of isoalloLCA in patients with inflammatory bowel diseases suggest a critical role for isoalloLCA and its bacterial producers in maintaining immune homeostasis in humans.

CELL HOST & MICROBE (2021)

Article Nutrition & Dietetics

Orphan Nuclear Receptor RORγ Modulates the Genome-Wide Binding of the Cholesterol Metabolic Genes during Mycotoxin-Induced Liver Injury

Kaiqi Li et al.

Summary: This study focused on the potential role of orphan nuclear receptor ROR gamma in regulating cholesterol in mycotoxin-exposed piglet livers. The results showed that mycotoxin exposure led to liver tissue damage, reduced cholesterol metabolism, and decreased binding of ROR gamma to cholesterol metabolic genes. These findings provide insights into cholesterol metabolism regulation during mycotoxin-induced liver injury and suggest NRs as therapeutic targets for anti-mycotoxin treatments.

NUTRIENTS (2021)

Review Gastroenterology & Hepatology

JAK-STAT pathway targeting for the treatment of inflammatory bowel disease

Azucena Salas et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Nutrition & Dietetics

Bile Acids as Metabolic Regulators and Nutrient Sensors

John Y. L. Chiang et al.

ANNUAL REVIEW OF NUTRITION, VOL 39, 2019 (2019)

Review Immunology

Treg cells in autoimmunity: from identification to Treg-based therapies

Lisa Goeschl et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

Article Multidisciplinary Sciences

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

Demin Cai et al.

NATURE COMMUNICATIONS (2019)

Correction Biochemistry & Molecular Biology

Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists (vol 11, pg 141, 2015)

Xiao Hu et al.

NATURE CHEMICAL BIOLOGY (2015)

Review Immunology

Cholesterol, inflammation and innate immunity

Alan R. Tall et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Cell Biology

Pleiotropic Roles of Bile Acids in Metabolism

Thomas Q. de Aguiar Vallim et al.

CELL METABOLISM (2013)

Article Nutrition & Dietetics

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

Laura Bravo

NUTRITION REVIEWS (2010)

Article Biochemistry & Molecular Biology

Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?

Anne M. Galea et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Review Nutrition & Dietetics

The health benefits of omega-3 polyunsaturated fatty acids: a review of the evidence

C. H. S. Ruxton et al.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2007)

Article Biochemical Research Methods

An HPLC method for the quantification of sterols in edible seaweeds

DI Sánchez-Machado et al.

BIOMEDICAL CHROMATOGRAPHY (2004)

Review Nutrition & Dietetics

The health benefits of omega-3 polyunsaturated fatty acids: a review of the evidence

CHS Ruxton et al.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2004)