☆ 4.3 Review

Clinical characteristics, treatment patterns and adherence in patients with asthma on multiple inhaler triple therapy: a review of findings

EXPERT REVIEW OF RESPIRATORY MEDICINE (2022)

Related references

Note: Only part of the references are listed.

Article Respiratory System

Global initiative for Asthma Strategy 2021: executive summary and rationale for key changes

Helen K. Reddel et al.

Summary: The GINA Strategy Report provides clinicians with an evidence-based strategy for asthma management and prevention, with specific recommendations and treatment options for different age groups and severity levels. Regular personalized assessment, treatment of modifiable risk factors, and appropriate medication adjustment and review remain essential for optimizing asthma outcomes.

EUROPEAN RESPIRATORY JOURNAL (2022)

Add to Collection

Article Allergy

Treatment Patterns and Disease Burden Associated with Multiple-Inhaler Triple-Therapy Use in Asthma

John Oppenheimer et al.

Summary: The prevalence of multiple-inhaler triple-therapy (MITT) use among patients with asthma is low, and patients initiating MITT have a substantial disease burden and unmet needs.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Add to Collection

Article Allergy

Usage of long-acting muscarinic antagonists and biologics as add-on therapy for patients in the United States with moderate-to-severe asthma

C. Victor Spain et al.

Summary: Between 2012 and 2019, the use of LAMA and biologics in asthma patients increased approximately 5-fold and 20-fold, respectively. Patients with concomitant COPD had a significantly higher initiation rate of LAMA compared to those with asthma only. High-dose ICS/LABA treatment and the need for oral corticosteroid bursts were strongly associated with biologic initiation. Discontinuation rates were higher for LAMAs compared to biologics, with asthma-only patients having higher discontinuation rates than those with COPD.

JOURNAL OF ASTHMA (2022)

Add to Collection

Review Allergy

Single inhaler triple therapy (SITT) in asthma: Systematic review and practice implications

Alvar Agusti et al.

Summary: Research has shown that adding LAMA can improve outcomes in patients with uncontrolled asthma despite ICS/LABA treatment. SITT has been proven to be a safe and effective alternative treatment option.

ALLERGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

An update on the currently available and emerging synthetic pharmacotherapy for uncontrolled asthma

Mario Cazzola et al.

Summary: The use of synthetic pharmacotherapy is a potential alternative to overcome resistance to corticosteroids and limitations of biological therapies for uncontrolled asthma. Certain pathways have been identified as potential targets for the development of new drugs against asthma.

EXPERT OPINION ON PHARMACOTHERAPY (2022)

Add to Collection

Article Primary Health Care

Characteristics and treatment patterns of patients with asthma on multiple-inhaler triple therapy in Spain

Miriam Barrecheguren et al.

Summary: This study aimed to describe characteristics, treatment patterns, and adherence among patients with asthma who initiated multiple-inhaler triple therapy (MITT). The findings revealed low adherence and substantial rates of step down/discontinuation among these patients.

NPJ PRIMARY CARE RESPIRATORY MEDICINE (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

The 5T approach in asthma: Triple Therapy Targeting Treatable Traits

Mario Cazzola et al.

Summary: Using a therapeutic strategy based on treatable traits may help overcome challenges in identifying and validating asthma phenotypes and endotypes. Triple therapy using a single inhaler has been shown to be effective in managing uncontrolled asthma and preventing exacerbations. Identifying treatable traits allows for a treatment strategy that is closer to precision medicine.

RESPIRATORY MEDICINE (2022)

Add to Collection

Article Allergy

Adherence and Persistence to Single-Inhaler Versus Multiple-Inhaler Triple Therapy for Asthma Management

Carlyne M. Averell et al.

Summary: This study compared adherence and persistence among adult asthma patients receiving single-inhaler FF/UMEC/VI versus multiple-inhaler triple therapy (MITT) in the United States, and found that patients initiating triple therapy with FF/UMEC/VI had significantly better adherence and persistence compared with MITT initiators.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Add to Collection

Article Respiratory System

The association between control level and self-reported treatment adherence across different treatment types in Japanese asthma patients

Yasuhiro Gon et al.

Summary: This study, based on data from the 2018 Japan National Health and Wellness Survey, found that about one-third of asthma patients in Japan have poorly controlled asthma. Patients with poor control status had worse health outcomes, indicating a need for better treatments to reduce the burden of asthma.

RESPIRATORY INVESTIGATION (2021)

Add to Collection

Article Critical Care Medicine

Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial

Laurie A. Lee et al.

Summary: In patients with uncontrolled moderate or severe asthma using ICS/LABA, adding UMEC improved lung function but did not significantly reduce moderate and/or severe exacerbations. Single-inhaler FF/UMEC/VI is an effective treatment option with a favorable risk-benefit profile. Higher dose FF primarily reduced exacerbations, especially in patients with elevated biomarkers of type 2 airway inflammation. Further studies are needed to confirm the effects of type 2 inflammatory biomarkers on treatment outcomes in asthma.

LANCET RESPIRATORY MEDICINE (2021)

Add to Collection

Meeting Abstract Critical Care Medicine

DISCONTINUATION AND RE-INITIATION OF MULTIPLE INHALER TRIPLE THERAPY IN ADULT PATIENTS WITH ASTHMA: A COHORT STUDY

Wilhelmine Meeraus et al.

CHEST (2021)

Add to Collection

Review Allergy

New Treatments for Asthma

Jenny Huang et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2021)

Add to Collection

Article Allergy

Cost-Effectiveness of Tiotropium in Elderly Patients with Severe Asthma Using Real-World Data

Sung-Hyun Hong et al.

Summary: The study evaluated the cost-effectiveness of adding tiotropium to inhaled corticosteroids and long-acting beta-agonists in elderly patients with severe asthma using real-world data. Results showed that tiotropium was cost-effective in patients with poorly controlled symptoms, while it was not a cost-effective alternative overall. The study provided important real-world evidence for establishing reimbursement criteria for tiotropium in elderly patients with severe asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Add to Collection

Review Allergy

Long-acting muscarinic antagonists and small airways in asthma: Which link?

Mario Cazzola et al.

Summary: Small airways play a crucial role in all stages of asthma and can be targeted for optimal asthma control. Antagonizing M-3 mAChR can prevent airway smooth muscle contraction, reduce inflammation, and halt remodeling. Further research is needed to differentiate the bronchodilatory and anti-inflammatory effects of LAMAs and understand their interaction with corticosteroids in treating asthma at different levels of the bronchial tree.

ALLERGY (2021)

Add to Collection

Article Health Care Sciences & Services

Cost-Effectiveness of Once-Daily, Single-Inhaler Indacaterol Acetate/ Glycopyrronium Bromide/Mometasone Furoate in Patients with Uncontrolled Moderate-to-Severe Asthma in Canada

Mondher Mtibaa et al.

Summary: The study found that high-dose indacaterol acetate/glycopyrronium bromide/mometasone furoate is more cost-effective in treating inadequately controlled moderate-to-severe asthma compared to other medications, significantly reducing costs and increasing QALYs.

CLINICOECONOMICS AND OUTCOMES RESEARCH (2021)

Add to Collection

Article Pharmacology & Pharmacy

The ALPACA study: (In)Appropriate LAMA prescribing in asthma: A cohort analysis

E. J. Baan et al.

Summary: The study shows that LAMA monotherapy in asthma patients has a low prevalence, but it is associated with an increased risk of exacerbations if not used concurrently with ICS.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2021)

Add to Collection

Review Respiratory System

Step-up and step-down approaches in the treatment of asthma

Mario Cazzola et al.

Summary: The current stepping approach to asthma treatment needs to be reassessed and modified. There are significant differences in opinions on the level of asthma control between patients and physicians. A more reasonable approach that sets individualized treatment goals and associates them with treatable traits of asthma is needed.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2021)

Add to Collection

Article Pharmacology & Pharmacy

Beclomethasone dipropionate, formoterol fumarate and glycopyrronium bromide: Synergy of triple combination therapy on human airway smooth muscle ex vivo

Paola Rogliani et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Add to Collection

Review Pharmacology & Pharmacy

Pharmacology and Therapeutics of Bronchodilators Revisited

M. G. Matera et al.

PHARMACOLOGICAL REVIEWS (2020)

Add to Collection

Article Medicine, General & Internal

Clinical characteristics, treatment patterns, disease burden, and persistence/adherence in patients with asthma initiating inhaled triple therapy: real-world evidence from Japan

Takeo Suzuki et al.

CURRENT MEDICAL RESEARCH AND OPINION (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

What drives inhaler prescription for asthma patients? Results from a real-life retrospective analysis

F. Lavorini et al.

RESPIRATORY MEDICINE (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Fixed-dose combination of indacaterol/glycopyrronium/mometasone furoate once-daily versus salmeterol/fluticasone twice-daily plus tiotropium once-daily in patients with uncontrolled asthma: A randomised, Phase IIIb, non-inferiority study (ARGON)

Christian Gessner et al.

RESPIRATORY MEDICINE (2020)

Add to Collection

Review Respiratory System

New perspectives on the role of muscarinic antagonists in asthma therapy

Maria Gabriella Matera et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2020)

Add to Collection

Article Allergy

Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age

Dennis E. Doherty et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

Add to Collection

Article Critical Care Medicine

Once-daily, single-inhaler mometasone–indacaterol–glycopyrronium versus mometasone–indacaterol or twice-daily fluticasone–salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study

Huib A M Kerstjens et al.

Lancet Respiratory Medicine (2020)

Add to Collection

Editorial Material Allergy

The latest on the role of LAMAs in asthma

Mario Cazzola et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Add to Collection

Article Allergy

2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group

Michelle M. Cloutier et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Add to Collection

Letter Allergy

Tiotropium reduces airflow obstruction in asthma patients, independent of body mass index

Sandhya Khurana et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Add to Collection

Review Cardiac & Cardiovascular Systems

Tiotropium in asthma: From bench to bedside

Lyndon Mansfield et al.

RESPIRATORY MEDICINE (2019)

Add to Collection

Article Medicine, General & Internal

Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials

Johann Christian Virchow et al.

LANCET (2019)

Add to Collection

Review Respiratory System

A potential role of triple therapy for asthma patients

Mario Cazzola et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2019)

Add to Collection

Article Allergy

Characterizing Real-World Use Of Tiotropium In Asthma In The USA

Carlyne M. Averell et al.

JOURNAL OF ASTHMA AND ALLERGY (2019)

Add to Collection

Article Respiratory System

Maintenance inhaler preference, attribute importance, and satisfaction in prescribing physicians and patients with asthma, COPD, or asthma-COPD overlap syndrome consulting for routine care

Bo Ding et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2018)

Add to Collection

Review Respiratory System

Role of muscarinic antagonists in asthma therapy

Mario Cazzola et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2017)

Add to Collection

Article Cardiac & Cardiovascular Systems

Tiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic status

Huib A. M. Kerstjens et al.

RESPIRATORY MEDICINE (2016)

Add to Collection

Article Respiratory System

Tiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life data

Oznur Abadoglu et al.

CLINICAL RESPIRATORY JOURNAL (2016)

Add to Collection

Article Critical Care Medicine

Long-term Outcomes After Stepping Down Asthma Controller Medications A Claims-Based, Time-to-Event Analysis

Matthew A. Rank et al.

CHEST (2015)

Add to Collection

Article Economics

Cost Effectiveness of Tiotropium in Patients with Asthma Poorly Controlled on Inhaled Glucocorticosteroids and Long-Acting β-Agonists

Jenny Willson et al.

APPLIED HEALTH ECONOMICS AND HEALTH POLICY (2014)

Add to Collection

Article Pharmacology & Pharmacy

Effects of tiotropium on lung function in severe asthmatics with or without emphysematous changes

Makoto Yoshida et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2013)

Add to Collection

Article Primary Health Care

Change in asthma and COPD prescribing by Italian general practitioners between 2006 and 2008

Mario Cazzola et al.

PRIMARY CARE RESPIRATORY JOURNAL (2011)

Add to Collection

Article Pharmacology & Pharmacy

Effects of fluticasone propionate/salmeterol combination on asthma-related health care resource utilization and costs and adherence in children and adults with asthma

Thomas E. Delea et al.

CLINICAL THERAPEUTICS (2008)

Add to Collection

Article Allergy

The long-acting beta-agonist controversy: A clinical dilemma

David M. Lang et al.

ALLERGY AND ASTHMA PROCEEDINGS (2007)

Add to Collection

© Peeref 2019-2024. All rights reserved.