Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin

Phosphaturic mesenchymal tumor (PMT) is strongly related to tumor-induced osteomalacia (TIO) which brings diverse skeletal events, such as bony deformities, gait disturbance, and multiple bone fractures. Overexpressed fibroblast growth factor 23 by the tumor induces hypophosphatemia leading to the oncogenic osteomalacia, a rare paraneoplastic syndrome. PMT occurring in the oral and maxillofacial regions is extremely rare, and this case highlights the need to understand mechanisms by which local lesions can affect systemic conditions, and the importance of a combination of physical examinations, laboratory investigations, and radiologic investigations for a decisive diagnosis.

Automated summary

Phosphaturic mesenchymal tumor (PMT) is strongly associated with tumor-induced osteomalacia (TIO), resulting in various skeletal problems including bone deformities, gait disturbance, and multiple bone fractures. The overexpression of fibroblast growth factor 23 by the tumor causes hypophosphatemia and leads to oncogenic osteomalacia, a rare paraneoplastic syndrome. PMT in the oral and maxillofacial regions is extremely rare, and this case emphasizes the importance of understanding the mechanisms by which local lesions can affect systemic conditions, as well as the significance of combining physical examinations, laboratory investigations, and radiologic investigations for an accurate diagnosis.