Journal
APPLIED SCIENCES-BASEL
Volume 12, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/app122211771
Keywords
bi-leaflet mechanical valve; effective orifice area; magnetic resonance imaging; acoustic source term
Categories
Funding
- NHMRC [APP1130610]
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This study explores the use of MRI patient data to assess the functioning of artificial heart valves. By utilizing 4D Phase-Contrast MRI and conducting experimental tests, the Effective Orifice Area (EOA) of the valves is evaluated and variation is observed. The results demonstrate the potential of MRI in assessing valve function and provide recommendations for clinical application.
Featured Application This work provides insight into how MRI patient data can be used to estimate how well an artificial heart valve is functioning in terms of the effective flow area. Background: This work aims at defining the Effective Orifice Area (EOA) derived from the acoustic source term (AST) method from 4D Phase-Contrast MRI data to provide a reference for the assessment of MRI valvular prostheses as part of a comprehensive cardiac exam. Methods: Three different Bileaflet Mechanical Heart Valves (BMHV) and a dysfunctional BMHV were tested in-vitro using 4D Phase-Contrast MRI and a numerical design of the experimental study was performed, including the influence of internal diameter, stroke volume, and heart rate. The EOA AST was computed based on the MRI 4D Phase-Contrast acquisition. Results: EOA(AST) values vary by 15 mm from the BMHV center and should be computed between 8 to 10 mm after the metallic blurring artefact (ranging from 18.9 to 23.4 mm from the BMHV). EOA(AST) values were found to be lower compared with numerical results in the appropriate plane. Detection of the BMHV dysfunction by continuity equation computed from 4D flow acquisition is limited based on EOAAST computations, while EOAc and velocities after the valves could more directly highlight a blocked leaflet. Conclusion: This multi-disciplinary study demonstrates the suitability of the EOA AST method to assess BMHV function using MRI. Translation to the clinic is feasible using an optimized 2D Phase-Contrast flow stack or a 4D Phase-Contrast minimal volume based on the recommendations provided.
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